Photoacoustic imaging devices and methods of imaging

• US 9,192,306 B2
• Filed: 09/09/2013
• Issued: 11/24/2015
• Est. Priority Date: 12/10/2007
• Status: Active Grant

• Current Assignee: UNM Rainforest Innovations (f/k/a STC.UNM) (The University of New Mexico)
• Original Assignee: UNM Rainforest Innovations (f/k/a STC.UNM) (The University of New Mexico)
• Inventors: Chen, Jingkuang
• Primary Examiner(s): ROZANSKI, MICHAEL T
• Application Number:
  US14/021,933
• Publication Number:
  US 20140012125A1
• Time in Patent Office: 806 Days
• Field of Search: 600/459, 600/407, 600/437, 600/347, 600/439, 600/443, 600/463, 600/547, 385/88, 385/31, 385/38, 385115-119, 385/89, 385/47, 437/60, 437/901, 437/919, 356/73, 295/94, 296/091, 250/227.11, 250/227.24, 250/227.2
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 5/0086 using infrared radiation
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 8/0833 involving detecting or locating foreign bodies or organic structures
• CPC Class Codes: A61B 8/12 in body cavities or body tracts, e.g. by using catheters catheters per se A61M25/00
• CPC Class Codes: A61B 8/4472 Wireless probes
• CPC Class Codes: A61B 8/4483 characterised by features of the ultrasound transducer
• CPC Class Codes: A61B 8/483 involving the acquisition of a 3D volume of data
• CPC Class Codes: Y10T 29/49826 Assembling or joining

Abstract

A photoacoustic medical imaging device may include a substrate, an array of ultrasonic transducers on the substrate, at least one groove etched on the substrate, at least one optical fiber, and at least one facet. Each optical fiber is disposed in one of the grooves. Each facet is etched in one of the grooves and coated with a layer of metal having high infrared reflectivity. Each optical fiber is configured to guide infrared light from a light source through the fiber and toward the respective facet. The facet is configured to reflect the infrared light toward a target.

Claims

1. A photoacoustic medical imaging device comprising:

a substrate having a first surface and a second surface, the first surface being a planar surface different from the second surface;

a first array of ultrasonic transducers on the first surface of the substrate;

a first groove etched on the first surface of the substrate;

a first optical fiber disposed in said first groove;

a first facet, said first facet etched in said first groove and coated with a layer of a first metal having high infrared reflectivity, said first optical fiber being configured to guide infrared light from a light source through said first optical fiber and toward said first facet, said first facet being configured to reflect the infrared light toward a target such that at least one ultrasonic transducer of said first array of ultrasonic transducers is arranged to receive an ultrasound from the target in response to the infrared light directed toward the target, the target being external to the photoacoustic medical imaging device;

a second array of ultrasonic transducers on the second surface of the substrate;

a second groove etched on the second surface of the substrate;

a second optical fiber disposed in said second groove etched on the second surface; and

a second facet etched in said second groove on the second surface and coated with a layer of a second metal having high infrared reflectivity, said second optical fiber being configured to guide infrared light from a second light source through said second optical fiber and toward said second facet, said second facet being configured to reflect the infrared light from the second light source external to the photoacoustic medical imaging device such that at least one ultrasonic transducer of the second array of ultrasonic transducers is arranged to operably receive an ultrasound in response to the infrared light directed external to the photoacoustic medical imaging device from the second facet.

2. The photoacoustic medical imaging device of claim 1, wherein said substrate comprises a silicon substrate.

3. The photoacoustic medical imaging device of claim 1, wherein said layer of the first metal comprises a layer of silver.

4. The photoacoustic medical imaging device of claim 1, wherein said first array of transducers comprises an array of capacitive micromachined ultrasonic transducers.

5. The photoacoustic medical imaging device of claim 1, wherein said first array of transducers comprises an array of piezoelectric ultrasound transducers.

6. The photoacoustic medical imaging device of claim 1, wherein said first groove is anisotropically etched on the substrate.

7. The photoacoustic medical imaging device of claim 1, wherein said first groove comprises a V-groove.

8. The photoacoustic medical imaging device of claim 1, wherein said first facet comprises a (111) facet.

9. A photoacoustic medical imaging device comprising:

a single substrate having a front viewing surface and having a plurality of surfaces defining a 360 degree view about an axis of the single substrate;

a plurality of arrays of ultrasonic transducers on the single substrate, an array of the plurality of arrays on each surface of the plurality of surfaces;

a plurality of grooves etched on the substrate, at least one groove associated with each said array of the plurality of arrays;

an array of ultrasonic transducers on the front viewing surface;

a plurality of optical fibers, each said optical fiber disposed in one of said grooves;

an optical fiber extending through the front viewing surface; and

a plurality of facets, each facet etched in one of said grooves and coated with a layer of metal having high infrared reflectivity, each of said optical fibers being configured to guide infrared light from a light source through said fiber and toward one of said facets, said one facet being configured to reflect the infrared light toward a target such that at least one ultrasonic transducer is arranged to receive an ultrasound from the target in response to the infrared light directed toward the target, the target being external to the photoacoustic medical imaging device.

10. The photoacoustic medical imaging device of claim 9, wherein said substrate comprises a silicon substrate.

11. The photoacoustic medical imaging device of claim 10, wherein said substrate comprises a flexible silicon substrate.

12. The photoacoustic medical imaging device of claim 9, wherein said layer of metal comprises a layer of silver.

13. The photoacoustic medical imaging device of claim 9, wherein each of said arrays of the plurality of arrays of ultrasonic transducers comprises an array of capacitive micromachined ultrasonic transducers.

14. The photoacoustic medical imaging device of claim 9, wherein each of said arrays of the plurality of arrays of ultrasonic transducers comprises an array of piezoelectric ultrasound transducers.

15. The photoacoustic medical imaging device of claim 9, wherein each of said plurality of grooves is anisotropically etched on the substrate.

16. The photoacoustic medical imaging device of claim 9, wherein each of said plurality of grooves comprises a V-groove.

17. The photoacoustic medical imaging device of claim 9, wherein the facet comprises a (111) facet.

18. The photoacoustic medical imaging device of claim 9, wherein said array of ultrasonic transducers on the front viewing surface is an annular array.

19. A method of making a photoacoustic medical imaging device, comprising:

integrating a plurality of arrays of ultrasonic transducers on a single substrate, each array on a different surface of the single substrate;

etching a plurality of grooves on the substrate, at least one groove being associated with each said array;

etching a facet in each one of said grooves;

coating each facet with a layer of metal having high infrared reflectivity;

performing a photolithography process to delimit a photoacoustic imager, said photoacoustic imager comprising a plurality of said arrays;

etching the substrate to release said photoacoustic imager from a remainder of the substrate; and

placing at least one optical fiber in each of said grooves, wherein the ultrasonic transducers, the facets, and the at least one optical fiber are arranged such that at least one ultrasonic transducer is arranged to receive an ultrasound from a target in response to infrared light from the at least one optical fiber to its corresponding facet directed toward the target, the target being external to the photoacoustic medical imaging device.

20. The method of claim 19, wherein the step of etching a facet comprises etching a (111) facet.