Mitral bioprosthesis with low ventricular profile

• US 9,192,466 B2
• Filed: 10/20/2011
• Issued: 11/24/2015
• Est. Priority Date: 10/21/2010
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Kovalsky, Igor, Clague, Cynthia
• Primary Examiner(s): PELLEGRINO, BRIAN E
• Application Number:
  US13/278,050
• Publication Number:
  US 20120101572A1
• Time in Patent Office: 1,496 Days
• Field of Search: 623/1.24, 623/1.26, 623/2.1, 623 212- 219, 623/1.3, 623/1.31
• US Class Current: 1/1
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2230/0013 Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2230/008 paraboloidal
• CPC Class Codes: A61F 2250/0039 differing in diameter
• CPC Class Codes: A61F 2250/0063 Nested prosthetic parts

Abstract

A heart valve prosthesis configured for placement at a mitral valve in the heart is disclosed that includes a stent-like support structure for supporting a prosthetic mitral valve. The support structure is configured to have a low ventricular profile with only a short length thereof protruding into the left ventricle when deployed in vivo. The support structure includes an upstream section that is outwardly expandable to sit against the atrial wall so as to at least partially anchor the prosthesis therein and a downstream section to which the prosthetic mitral valve is coupled that extends between the left atria and ventricle through the native mitral valve. The low-ventricular profile of the prosthesis is achieved by shaping the support structure such that the downstream section extends within and overlaps with the upstream section at given regions around the circumference of the support structure in an expanded configuration.

Claims

1. A valve prosthesis configured for percutaneous deployment at a mitral valve in the heart, the prosthesis comprising:

a support structure configured to support a prosthetic heart valve, wherein the support structure has a stent framework having an upstream section with a greater expanded diameter than a downstream section, and defining a plurality of continuous regions and a plurality of discontinuous regions that alternate with one another around a circumference of the stent framework,

wherein each of the continuous regions of the stent framework forms a longitudinally extending band of cells that are connected to each other from an upstream end to a downstream end of the stent framework, and wherein each of the discontinuous regions of the stent framework forms a longitudinally extending band of cells from the upstream end to the downstream end of the stent framework with neighboring cells between the upstream and downstream sections being unconnected from one and other, and

wherein within each of the discontinuous regions of the stent framework the unconnected cell of the downstream section at least partially overlaps with the unconnected cell of the upstream section by longitudinally extending within the upstream section of the stent framework such that the unconnected cell of the downstream section is positioned radially inward of the unconnected cell of the upstream section.

2. The valve prosthesis of claim 1, wherein struts of the stent framework define the cells of the continuous and discontinuous regions.

3. The valve prosthesis of claim 1, wherein the unconnected cell of the downstream section forms an upstream interior end of the downstream section within each of the discontinuous regions.

4. The valve prosthesis of claim 3 further comprising:

a prosthetic tricuspid heart valve attached to the downstream section of the stent framework with each of the prosthetic leaflets being attached at its highest point of curvature to a corresponding upstream interior end of the downstream section.

5. The valve prosthesis of claim 3, wherein within each of the discontinuous regions the unconnected cell of the upstream section inwardly curves and is configured to be a barb to secure the support structure upon deployment in vivo.

6. The valve prosthesis of claim 1, wherein the downstream section of the stent framework in an expanded configuration defines a cylinder that includes short segments of a length L1 and long segments of a length L2 that is longer than the length L1.

7. The valve prosthesis of claim 6, wherein the short segments of the downstream section are in the continuous regions of the stent framework and the long segments of the downstream section are in the discontinuous regions of the stent framework to alternate with one another around a circumference of the stent framework.

8. The valve prosthesis of claim 7, wherein the long segments of the downstream section have an upstream interior end that extends inside of the upstream section to create the at least partial overlap between the upstream and downstream sections in each of the discontinuous regions.

9. The valve prosthesis of claim 8 further comprising:

a prosthetic tricuspid heart valve attached to the downstream section of the stent framework with each of the prosthetic leaflets being attached at its highest point of curvature to a corresponding upstream interior end of the downstream section.

10. The valve prosthesis of claim 6, wherein length L2 of the cylinder is between 14 mm and 18 mm and length L1 of the cylinder is between 8 mm and 13 mm.

11. The valve prosthesis of claim 1 further comprising:

a lining secured within the stent framework to provide a smooth flow surface within the discontinuous regions.

12. A valve prosthesis configured for percutaneous deployment at a mitral valve in the heart, the prosthesis comprising:

a support structure configured to support a prosthetic heart valve having an upstream section with a greater expanded diameter than a downstream section, the support structure defining a plurality of cells wherein at spaced locations around a circumference of the support structure the support structure has discontinuous regions in which a cell of the upstream section is detached from a longitudinally adjacent cell of the downstream section, and wherein within each of the discontinuous regions the detached cell of the downstream section of the support structure at least partially overlaps with the detached cell of the upstream section of the support structure by longitudinally extending within the upstream section of the support structure such that the detached cell of the downstream section is positioned radially inward of the detached cell of the upstream section to create the at least partial overlap between the upstream and downstream sections.

13. The valve prosthesis of claim 12, wherein within each of the discontinuous regions the longitudinally adjacent detached cell of the downstream section forms an upstream interior end of the downstream section.

14. The valve prosthesis of claim 13 further comprising:

a prosthetic tricuspid heart valve attached to the downstream section of the support structure with each of the prosthetic leaflets being attached at its highest point of curvature to a corresponding upstream interior end of the downstream section.

15. The valve prosthesis of claim 12, wherein within each of the discontinuous regions the detached cell of the upstream section inwardly curves and is configured to be a barb to secure the support structure upon deployment in vivo.

16. The valve prosthesis of claim 12 further comprising:

a lining secured within the support structure to provide a smooth flow surface therein.

17. The valve prosthesis of claim 16, wherein the lining covers an interior of the support structure where the downstream section of the support structure at least partially overlaps with the upstream section of the support structure to prevent blood stagnation.