Focused ultrasonic renal denervation
First Claim
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1. An apparatus, comprising:
- a first catheter including a central shaft and an inflatable balloon, the first catheter configured for deployment within a vessel proximate innervated tissue that contributes to renal sympathetic nerve activity;
a second catheter slidable relative to the first catheter;
a spiral rail mounted on an outer surface of the central shaft adjacent a distal end of the central shaft within an interior volume of the inflatable balloon;
an acoustic transducer provided at the distal end of the second catheter and dimensioned for deployment within the vessel proximate the innervated tissue, wherein the second catheter includes a keyed channel member that is disposed around an outer surface of the spiral rail such that the acoustic transducer is translated along a helical path as the acoustic transducer is distally advanced or proximally retracted;
a focusing arrangement configured to focus acoustic energy outwardly beyond an inner wall of the vessel and into the innervated tissue at or proximate an outer wall of the vessel; and
a controller configured to control the acoustic transducer for at least one of scanning tissue and ablating the innervated tissue.
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Abstract
Acoustic energy is delivered to innervated vascular that contributes to renal sympathetic nerve activity, such as innervated tissue of the renal artery and abdominal aorta. Focused acoustic energy is delivered via an intravascular device of sufficient power to ablate innervated renal or aortal tissue. Focused acoustic energy may be delivered via an intravascular or extracorporeal device to image and locate target innervated renal or aortal tissue. Intravascular, extravascular, or transvascular focused ultrasound devices provide for high precision denervation of innervated vascular to terminate renal sympathetic nerve activity.
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Citations
18 Claims
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1. An apparatus, comprising:
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a first catheter including a central shaft and an inflatable balloon, the first catheter configured for deployment within a vessel proximate innervated tissue that contributes to renal sympathetic nerve activity; a second catheter slidable relative to the first catheter; a spiral rail mounted on an outer surface of the central shaft adjacent a distal end of the central shaft within an interior volume of the inflatable balloon; an acoustic transducer provided at the distal end of the second catheter and dimensioned for deployment within the vessel proximate the innervated tissue, wherein the second catheter includes a keyed channel member that is disposed around an outer surface of the spiral rail such that the acoustic transducer is translated along a helical path as the acoustic transducer is distally advanced or proximally retracted; a focusing arrangement configured to focus acoustic energy outwardly beyond an inner wall of the vessel and into the innervated tissue at or proximate an outer wall of the vessel; and a controller configured to control the acoustic transducer for at least one of scanning tissue and ablating the innervated tissue. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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Specification