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Hemoglobin contrast in magneto-motive optical doppler tomography, optical coherence tomography, and ultrasound imaging methods and apparatus

  • US 9,198,596 B2
  • Filed: 12/20/2012
  • Issued: 12/01/2015
  • Est. Priority Date: 05/27/2005
  • Status: Expired due to Fees
First Claim
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1. A method for detecting a lymphocyte, comprising:

  • applying a first magnetic field strength to the lymphocyte, wherein the lymphocyte comprises a cellular membrane and a magnetically susceptible material;

    applying a second magnetic field strength to the lymphocyte, wherein the second magnetic field strength is different from the first magnetic field strength and interacts with the magnetically susceptible material to cause a change in the lymphocyte relative to interaction of the lymphocyte with the first magnetic field strength; and

    detecting the lymphocyte by detecting the change in the lymphocyte, wherein the change is detected using a phase sensitive frequency domain optical coherence tomographic imaging modality including a common path interferometer during the application of at least one of the first and second magnetic field strengths.

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