Biological photometric device and biological photometry method using same

• US 9,198,624 B2
• Filed: 07/06/2011
• Issued: 12/01/2015
• Est. Priority Date: 07/06/2010
• Status: Active Grant

• Current Assignee: FUJIFILM Healthcare Corp. (Fujifilm Holdings Corporation)
• Original Assignee: Hitachi Medical Corporation (Hitachi, Ltd.)
• Inventors: Funane, Tsukasa, Atsumori, Hirokazu, Katura, Takusige, Kiguchi, Masashi, Takatera, Tsuyoshi, Fujiwara, Michiyuki
• Primary Examiner(s): ROZANSKI, MICHAEL T
• Application Number:
  US13/806,790
• Publication Number:
  US 20130102907A1
• Time in Patent Office: 1,609 Days
• Field of Search: 600/310, 600/323, 600/324, 600/331, 600/473, 600/476, 600/477
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0042 for the brain
• CPC Class Codes: A61B 5/0075 by spectroscopy, i.e. measuring spectra, e.g. Raman spectroscopy, infrared absorption spectroscopy A61B5/0071 takes precedence
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61B 6/00 Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment instruments measuring radiation intensity for application in the field of nuclear medicine, e.g. in vivo counting, G01T1/161; apparatus for taking X-ray photographs G03B42/02
• CPC Class Codes: G01N 21/359 using near infrared light
• CPC Class Codes: G01N 21/49 within a body or fluid

Abstract

The present invention is capable of separating/removing the influence of skin blood flow contained in near infrared spectroscopy (NIRS) signals and extracting a brain- or brain cortex-origin signal. Moreover, the present invention enables versatile separation of brain-origin and skin-origin signals in view of differences among individuals. A biological photometric device, wherein light transmitters and light receivers are located in such a manner that measurement can be conducted at a plurality of source-detector (SD) distances and light received by the individual light-receivers can pass through the gray matter to thereby separate a brain-origin signal and a skin-origin signal. Individual component analysis (ICA) is conducted on data obtained at the individual measurement points. Then, it is determined whether each individual component originates in the brain or in the skin with the use of the SD distance-dependency of the weighted value of each of the separated components.

Claims

1. A biological photometric device, comprising:

one or more light sources, each irradiating light on a subject;

a plurality of light detectors, each detecting the light, which is irradiated on an irradiation point on the subject from one of the light sources and propagated in the subject, at a detection point on the subject; and

a calculator that analyzes signals obtained by the light detectors,

wherein each of the light sources and each of the light detectors are configured to be disposed on the subject such that SD distance defined on the subject as a distance between the irradiation point and the detection point, is spaced as at least two types of spacing, and

the calculator extracts a plurality of separated components including a deep portion component reflecting signal from brain of the subject and a shallow portion component reflecting signal from scalp of the subject using a signal separation method from a plurality of measurement data respectively measured by combinations of the light source and the light detector having different values of the SD distances from one another, analyzes a first dependency of weight of the deep portion component within the measurement data with respect to the SD distance or a partial optical path length in gray matter and a second dependency of weight of the shallow portion component within measurement data with respect to the SD distance or the partial optical path length in gray matter by performing regression analysis and reconstructs the deep portion component and the shallow portion component of the measurement data according to the first dependency of weight of the deep portion component and the second dependency of weight of the shallow portion component.

2. The biological photometric device according to claim 1,

wherein the calculator uses the parameter to calculate a contribution ratio of a deep portion and a shallow portion in a shared component that contains both of the signal from brain of the subject and signal from scalp of the subject and uses a weight which is proportional to the contribution ratio to reconstruct the deep portion component and the shallow portion component.

3. The biological photometric device according to claim 1, wherein the plurality of light detectors is disposed so as to detect a signal from at least two light sources having different SD distances among signals from the plurality of light sources which is configured to be disposed within a radius of 60 mm from the light detector on the subject.

4. The biological photometric device according to claim 1, wherein the one or plurality of light detectors detects a signal from at least two kinds of the plurality of light sources at different timing.

5. The biological photometric device according to claim 1, wherein the one or plurality of light detectors is disposed so as to detect the light that is irradiated from the one or plurality of light sources and propagated in a gray matter of the subject.

6. The biological photometric device according to claim 1, wherein the first and second dependencies are expressed as a function g (w, u, σ

)=w×

(u^2+σ

^2)^(0.5) or a function g(w)=w (w is a weight value, u is a mean amplitude value of the separated component, and σ

is a standard deviation of an amplitude value of the separated component).

7. The biological photometric device according to claim 1, comprising:

a controller that controls the one or plurality of light sources and the one or plurality of light detectors;

wherein the controller controls a power of the light irradiated from the light sources depending on the SD distance or a power of the light detected by the light detectors.

8. The biological photometric device according to claim 1, comprising:

a controller that controls the one or plurality of light sources and the one or plurality of light detectors;

wherein the controller switches use or nonuse of respective ones of the light sources or the light detecting units detectors in accordance with time.

9. The biological photometric device according to claim 1, comprising:

a display that displays an analysis result in the calculator;

wherein the display displays the separated components so as to divide the separated components into a shallow portion signal, a deep portion signal, a signal which is commonly included in the shallow portion and the deep portion, or divide signals in a plurality of SD distances, or divide signals in a measurement portion including at least one of a frontal region, a temporal region, a parietal region, and an occipital region of head of the subject, or divide the separated components into a response signal of a task including at least one of a memory task, a motor task, a verbal task, and a visual task.

10. The biological photometric device according to claim 1, further comprising:

a support that supports the light sources and the light detectors;

wherein the support additionally or detachably supports an auxiliary light detector in order to increase measurement points, and

the auxiliary light detector detects the light at a timing when the auxiliary light detector is synchronized with at least one of the plurality of light detectors.

11. The biological photometric device according to claim 1, further comprising:

a controller that controls the one or plurality of light sources and the one or plurality of light detectors;

an input part that manually inputs a control method in the controller and an analysis method in the calculator.

12. The biological photometric device according to claim 1, wherein the plurality of light sources and the plurality of light detectors are disposed such that the SD distance in at least two measurement points is larger than approximately 10 mm and in this case, approximately 10 mm is 7 mm or larger and smaller than 13 mm.

13. The biological photometric device according to claim 1, wherein a component including at least one of a biological signal in a shallow portion of the subject, a biological signal in a deep portion, a systemic biological signal, a device noise, and a noise due to a body motion, is separated and extracted.

14. The biological photometric device according to claim 1, wherein the calculator analyzes the first dependency by deriving model parameters of a first regression curve through fitting the first regression curve to function values of weight of the deep portion component within the measurement data corresponding to various values of the SD distance, and analyzes the second dependency by deriving model parameters of a second regression curve through fitting the second regression curve to function values of weight of the shallow portion component within the measurement data corresponding to various values of the SD distance.

15. The biological photometric device according to claim 14, wherein the calculator reconstructs the deep portion component and the shallow portion component of the measurement data by determining a threshold value of gradient from the first gradient and the second gradient and by segregating respective ones of the separated components into deep portion components and shallow portion components based on the determined threshold value of gradient.

16. The biological photometric device according to claim 1, wherein the calculator analyzes the first dependency by deriving a first gradient of a first regression line through fitting the first regression line to function values of weight of the deep portion component within the measurement data corresponding to various values of the SD distance, and analyzes the second dependency by deriving a second gradient of a second regression line through fitting the second regression line to function values of weight of the shallow portion component within the measurement data corresponding to various values of the SD distance.

17. A biological photometric method that uses a biological photometric device including:

one or more light sources that irradiates light on a subject;

a plurality of light detectors that detects the light, which is irradiated on an irradiation point on the subject from the one or more light sources and propagated in the subject, at a detection point on the subject; and

a calculator that analyzes a signal obtained by the one or plurality of light detectors, the method comprising;

disposing each of the light sources and each of the light detectors on the subject such that SD distance defined on the subject as a distance between the irradiation point and the detection point, is spaced as at least two types of spacing;

extracting a plurality of separated components including a deep portion component reflecting signal from brain of the subject and a shallow portion component reflecting signal from scalp of the subject using a signal separation method from a plurality of measurement data respectively measured by combinations of the light source and the light detector having different values of the SD distance from on another;

analyzing a first dependency of weight of the deep portion component within the measurement data with respect to the SD distance or a partial optical path length in gray matter and a second dependency of weight of the shallow portion component within measurement data with respect to the SD distance or the partial optical path length in gray matter by performing regression analysis; and

reconstructing the deep portion component and the shallow portion component of the measurement data according to the first dependency of weight of the deep portion component and the second dependency of weight of the shallow portion component.