Implant surface with increased hydrophilicity

• US 9,198,742 B2
• Filed: 08/27/2014
• Issued: 12/01/2015
• Est. Priority Date: 01/28/2008
• Status: Active Grant

• Current Assignee: Biomet 3i LLC (Zimvie Incorporated)
• Original Assignee: Biomet 3i LLC (Zimvie Incorporated)
• Inventors: Marks, Jacqueline K., Mayfield, Robert L., Towse, Ross W.
• Primary Examiner(s): Feely, Michael J
• Application Number:
  US14/470,915
• Publication Number:
  US 20140370461A1
• Time in Patent Office: 461 Days
• Field of Search: 427/2.24, 427/2.25, 427/2.26, 427/2.27, 433/201.1
• US Class Current: 1/1
• CPC Class Codes: A61C 8/0012 characterised by the material or composition, e.g. ceramics, surface layer, metal alloy use of specific materials A61K6/00
• CPC Class Codes: A61C 8/0013 with a surface layer, coating
• CPC Class Codes: A61C 8/0022 Self-screwing A61C8/0028 takes precedence
• CPC Class Codes: A61C 8/005 Connecting devices for joining an upper structure with an implant member, e.g. spacers
• CPC Class Codes: A61C 8/006 with polygonal positional means, e.g. hexagonal or octagonal
• CPC Class Codes: A61K 6/802 comprising ceramics
• CPC Class Codes: A61K 6/84 comprising metals or alloys
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 2430/12 for dental implants or prostheses
• CPC Class Codes: A61L 27/06 Titanium or titanium alloys
• CPC Class Codes: A61L 27/10 Ceramics or glasses
• CPC Class Codes: A61L 27/306 Other specific inorganic materials not covered by A61L27/303 - A61L27/32
• CPC Class Codes: A61L 27/32 Phosphorus-containing materials, e.g. apatite
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: C23F 1/30 for etching other metallic material

Abstract

A method of increasing the hydrophilicity of an implant to be implanted into living bone. The method comprises the act of depositing non-toxic salt residuals on the surface of the implant by exposing the surface to a solution including the non-toxic salts. The method further comprises the act of drying the implant.

Claims

1. A method of forming an implant to be implanted into living bone, the method comprising the acts of:

roughening at least a portion of the implant surface to form a roughened surface; and

increasing the hydrophilicity of the roughened surface by depositing at least one non-toxic salt residual on the roughened surface, the at least one non-toxic salt residual including sodium lactate.

2. The method of claim 1, further comprising, prior to the act of roughening, grit blasting at least a portion of the implant surface with a grit blast media.

3. The method of claim 2, wherein the grit blast media is a resorbable grit blast media.

4. The method of claim 3, wherein the resorbable grit blast media includes calcium phosphate.

5. A dental implant comprising:

a head portion having a non-rotational feature;

a lowermost end opposing the head portion; and

a threaded bottom portion for engaging bone between the head portion and the lowermost end, the threaded bottom portion having a roughened surface with an array of microscale irregularities, the threaded bottom portion further including at least one non-toxic salt residual located on the roughened surface, the at least one non-toxic salt residual including sodium lactate.

6. The implant of claim 5, wherein the implant is made of a metal selected from the group consisting of titanium and titanium alloys.

7. The dental implant of claim 5, wherein the microscale irregularities have peak-to-valley heights not greater than about 20 microns.

8. The dental implant of claim 5, wherein the at least one non-toxic salt residual is configured to increase the hydrophilicity of the roughened surface.

9. The dental implant of claim 5, wherein the roughened surface further includes discrete nanoparticles comprising a material having a property that promotes osseointegration.

10. The dental implant of claim 9, wherein the nanoparticles are hydroxyapatite nanocrystals.

11. The dental implant of claim 5, wherein a contact angle formed by a deionized water droplet on the surface of the implant ranges from about 5°

to about 65°

.

12. The dental implant of claim 5, wherein the roughened surface is a grit blasted surface.

13. A dental implant comprising:

a head portion having a non-rotational feature;

a lowermost end opposing the head portion; and

a threaded bottom portion for engaging bone between the head portion and the lowermost end, the threaded bottom portion having a roughened surface with an array of microscale irregularities, the threaded bottom portion further including discrete non-toxic salt residuals located on the roughened surface, the discrete non-toxic salt residuals including sodium lactate.

14. The dental implant of claim 13, wherein the implant is made of titanium or titanium alloy.

15. The dental implant of claim 13, wherein the microscale irregularities have peak-to-valley heights not greater than about 20 microns.

16. The dental implant of claim 13, wherein the discrete non-toxic salt residuals are configured to increase the hydrophilicity of the roughened surface.

17. The dental implant of claim 13, wherein the roughened surface further includes discrete nanoparticles comprising a material having a property that promotes osseointegration.

18. The dental implant of claim 17, wherein the nanoparticles are hydroxyapatite nanocrystals.

19. The dental implant of claim 13, wherein a contact angle formed by a deionized water droplet on the surface of the implant ranges from about 5°

to about 65°

.

20. The dental implant of claim 13, wherein the roughened surface is a grit blasted surface.