Modified release formulations containing drug-ion exchange resin complexes
First Claim
1. A solid pharmaceutical orally disintegrating tablet comprising:
- (a) drug-ion exchange resin complex particles that are uncoated and which comprise methylphenidate bound to an ion exchange resin, and(b) modified release coated drug-ion exchange resin complex particles which comprise methylphenidate bound to an ion exchange resin, wherein said modified release coated drug-ion exchange resin complex particles (b) further comprise a hydrophilic polymer or water insoluble polymer or copolymer in a matrix with the drug-ion exchange resin complex, wherein the modified release coating is over the drug-ion exchange resin complex-matrixwherein the weight ratio of (a) to (b) is about 2;
1 to about 1;
10.
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Accused Products
Abstract
A tablet comprising a coated drug-ion exchange resin complex composed of methylphenidate complexed with a pharmaceutically acceptable ion-exchange resin and an uncoated methylphenidate-ion exchange resin complex is provided. The coated methylphenidate-ion exchange resin complex is in admixture with a polymer to form a matrix. Also provided is a tablet comprising a coated drug-ion exchange resin complex composed of dexmethylphenidate complexed with a pharmaceutically acceptable ion-exchange resin and an uncoated dexmethylphenidate-ion exchange resin complex is provided. The coated dexmethylphenidate-ion exchange resin complex is in admixture with a polymer to form a matrix.
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Citations
14 Claims
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1. A solid pharmaceutical orally disintegrating tablet comprising:
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(a) drug-ion exchange resin complex particles that are uncoated and which comprise methylphenidate bound to an ion exchange resin, and (b) modified release coated drug-ion exchange resin complex particles which comprise methylphenidate bound to an ion exchange resin, wherein said modified release coated drug-ion exchange resin complex particles (b) further comprise a hydrophilic polymer or water insoluble polymer or copolymer in a matrix with the drug-ion exchange resin complex, wherein the modified release coating is over the drug-ion exchange resin complex-matrix wherein the weight ratio of (a) to (b) is about 2;
1 to about 1;
10. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A solid pharmaceutical orally disintegrating tablet comprising:
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(a) drug-ion exchange resin complex particles that are uncoated and which comprise dexmethylphenidate bound to an ion exchange resin, and (b) modified release coated drug-ion exchange resin complex particles which comprise dexmethylphenidate bound to an ion exchange resin, wherein said modified release coated drug-ion exchange resin complex particles (b) further comprise a hydrophilic polymer or water insoluble polymer or copolymer in a matrix with the drug-ion exchange resin complex, wherein the modified release coating is over the drug-ion exchange resin complex-matrix wherein the weight ratio of (a) to (b) is about 2;
1 to about 1;
10. - View Dependent Claims (9, 10, 11, 12, 13, 14)
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Specification