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Controlled delivery of bioactive agents from decomposable films

  • US 9,198,875 B2
  • Filed: 08/17/2009
  • Issued: 12/01/2015
  • Est. Priority Date: 08/17/2008
  • Status: Active Grant
First Claim
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1. A decomposable thin film, comprising:

  • at least one multilayer repeat unit, the multilayer repeat unit including at least a first polyelectrolyte layer and a second polyelectrolyte layer, the first polyelectrolyte layer having a first electrostatic charge and the second polyelectrolyte layer having a second electrostatic charge, the first and second electrostatic charges being opposite, wherein;

    the first polyelectrolyte layer comprises a polycyclodextrin; and

    the second polyelectrolyte layer comprises a degradable polyelectrolyte,wherein the polycyclodextrin is non-covalently associated with a bioactive agent, andwherein the bioactive agent is a hydrophobic molecule.

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