Compositions and methods for treating and preventing coronary heart disease
First Claim
1. A method of characterizing a subject'"'"'s response to a cholesterol lowering therapy, the method comprising:
- determining a level of cholesterol in a sample obtained from a patient;
conducting an assay in the sample to identify a polymorphism associated with statin efficacy, wherein the polymorphism is selected from the group consisting of a SLCO1B1 polymorphism, an Apolipoprotein E (ApoE) polymorphism, and a combination of a SLCO1B1 polymorphism and an ApoE polymorphism;
establishing weighted values based on the level of cholesterol and a genotype of the polymorphism; and
characterizing said patient'"'"'s likelihood of responding to a cholesterol lowering therapy based on said weighted values.
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Accused Products
Abstract
The invention pertains to a method of determining a statin dosage for an individual in need of treatment with a statin, comprising determining a SLCO1B1 genotype from a nucleic acid sample of the individual, said genotype comprising the presence or absence of the SLCO1B1-056 polymorphism, and determining an ApoE genotype or phenotype identifying an ApoE polymorphism selected from the group consisting of ApoE2, ApoE3, ApoE4, and any combination thereof, wherein the combination of a SLCO1B1 genotype identifying the presence of the SLCO1B1-056 C polymorphism and the ApoE genotype or phenotype identifying one of the ApoE3/4 or ApoE4/4 genotypes indicates the statin dosage.
60 Citations
17 Claims
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1. A method of characterizing a subject'"'"'s response to a cholesterol lowering therapy, the method comprising:
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determining a level of cholesterol in a sample obtained from a patient; conducting an assay in the sample to identify a polymorphism associated with statin efficacy, wherein the polymorphism is selected from the group consisting of a SLCO1B1 polymorphism, an Apolipoprotein E (ApoE) polymorphism, and a combination of a SLCO1B1 polymorphism and an ApoE polymorphism; establishing weighted values based on the level of cholesterol and a genotype of the polymorphism; and characterizing said patient'"'"'s likelihood of responding to a cholesterol lowering therapy based on said weighted values. - View Dependent Claims (2, 3, 4, 5, 6, 7)
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8. A method of determining a cholesterol lowering therapy of a subject, the method comprising:
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determining a level of cholesterol in a sample obtained from a patient; conducting an assay in the sample to identify the presence or absence of a biomarker associated with statin efficacy, wherein the biomarker is one or more genes selected from the group consisting of SLCO1B1 and Apolipoprotein E (ApoE); establishing weighted values based on the level of cholesterol and the presence or absence of the biomarker; determining a dosage of a drug for reducing cholesterol based on the weighted value; and administering the dosage of the drug to the patient. - View Dependent Claims (9, 10, 11, 12, 13, 14, 15, 16, 17)
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Specification