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Local delivery of water-soluble or water-insoluble therapeutic agents to the surface of body lumens

  • US 9,198,968 B2
  • Filed: 09/11/2009
  • Issued: 12/01/2015
  • Est. Priority Date: 09/15/2008
  • Status: Active Grant
First Claim
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1. A method of coating a medical disposable device comprising:

  • preparing a first solution comprising a water-insoluble drug, a first lower alcohol, and acetone;

    preparing a second solution comprising a second lower alcohol, non-covalently bound iodine, and an amphiphilic polymer;

    mixing the first and second solutions to form a coating solution; and

    dip coating an expandable structure of a medical disposable device in the coating solution to form a non-durable coating on the expandable structure,wherein the non-covalently bound iodine is complexed with the amphiphilic polymer and the water-insoluble drug is dispersed throughout the non-durable coating.

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