Drug-delivery pumps with dynamic, adaptive control
First Claim
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1. A drug-delivery pump operating at period time intervals, comprising:
- a drug reservoir configured to hold a liquid drug;
a cannula for conducting the liquid drug from the reservoir to a target site;
a pump actuator comprising electrolysis electrodes driven by a current for forcing the liquid drug from the reservoir through the cannula;
at least one physical sensor for measuring at least one quantitative electrical or flow pump operating parameter;
a memory for storing (i) a fixed dosage of the liquid drug to be delivered by the pump actuator through the cannula during each of a plurality of dosing intervals and (ii) a value of the at least one quantitative pump operating parameter measured by the at least one physical sensor obtained during a previous at least one dosing intervals interval, the pump actuator being operative during the previous dosing interval to deliver the fixed dosage; and
circuitry for controlling the current supplied to the pump actuator by computing actuator settings based at least in part on the stored fixed dosage and a change in a condition of the pump actuator specified by a quantitative difference between the stored value of the pump operating parameter and a current value of the pump operating parameter, and adjusting the pump actuator in accordance with the computed actuator settings to thereby compensate for the change in a maximum flow rate reached while the current is supplied to the actuator pump in the current dosing interval or an amount of liquid delivered due to residual pressure after the current is no longer supplied to the actuator pump in the current dosing interval.
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Abstract
In various embodiments, actuation of a drug-delivery pump is controlled based on a change in a condition of the pump.
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Citations
18 Claims
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1. A drug-delivery pump operating at period time intervals, comprising:
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a drug reservoir configured to hold a liquid drug; a cannula for conducting the liquid drug from the reservoir to a target site; a pump actuator comprising electrolysis electrodes driven by a current for forcing the liquid drug from the reservoir through the cannula; at least one physical sensor for measuring at least one quantitative electrical or flow pump operating parameter; a memory for storing (i) a fixed dosage of the liquid drug to be delivered by the pump actuator through the cannula during each of a plurality of dosing intervals and (ii) a value of the at least one quantitative pump operating parameter measured by the at least one physical sensor obtained during a previous at least one dosing intervals interval, the pump actuator being operative during the previous dosing interval to deliver the fixed dosage; and circuitry for controlling the current supplied to the pump actuator by computing actuator settings based at least in part on the stored fixed dosage and a change in a condition of the pump actuator specified by a quantitative difference between the stored value of the pump operating parameter and a current value of the pump operating parameter, and adjusting the pump actuator in accordance with the computed actuator settings to thereby compensate for the change in a maximum flow rate reached while the current is supplied to the actuator pump in the current dosing interval or an amount of liquid delivered due to residual pressure after the current is no longer supplied to the actuator pump in the current dosing interval. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A drug-delivery pump comprising:
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a drug reservoir configured to hold a liquid drug; a cannula for conducting the liquid drug from the reservoir to a target site; a pump actuator comprising electrolysis electrodes driven by a current for forcing the liquid from the reservoir through the cannula during a plurality of dosing cycles; at least one physical sensor for measuring at least one quantitative electrical or flow pump operating parameter; a memory for storing (i) a fixed dosage to be delivered by the pump actuator through the cannula during each of a plurality of different dosing cycles and (ii) values of the at least one quantitative electrical or flow pump operating parameter measured by the at least one physical sensor obtained during each of the plurality of different dosing cycles, the pump actuator being operative during each of the plurality of different dosing cycles to deliver the fixed dosage; and circuitry for adaptively controlling the current supplied to the pump actuator by computing actuator settings for a new dosing cycle based at least in part on the stored fixed dosage and a change in the values between the plurality of different dosing cycles stored in the memory, and adjusting the pump actuator in accordance with the computed actuator settings to thereby compensate for a change in a maximum flow rate reached while the current is supplied to the actuator pump or an amount of liquid delivered due to residual pressure after the current is no longer supplied to the actuator pump.
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Specification