Device and method for compartmental vessel treatment

• US 9,199,066 B2
• Filed: 03/09/2011
• Issued: 12/01/2015
• Est. Priority Date: 03/12/2010
• Status: Active Grant

• Current Assignee: Trireme Medical Incorporated
• Original Assignee: Quattro Vascular Pte Limited
• Inventors: Konstantino, Eitan, Feld, Tanhum
• Primary Examiner(s): LOUIS, RICHARD G
• Application Number:
  US13/044,425
• Publication Number:
  US 20120059401A1
• Time in Patent Office: 1,728 Days
• Field of Search: 606191-192, 606/194, 606/159, 604/507, 604/509
• US Class Current: 1/1
• CPC Class Codes: A61B 17/22 Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for dilators A61M29/00
• CPC Class Codes: A61B 2017/22001 Angioplasty, e.g. PCTA
• CPC Class Codes: A61B 2017/22051 with an inflatable part, e.g. balloon, for positioning, blocking, or immobilisation A61B2017/22048, A61B2017/3486 take precedence
• CPC Class Codes: A61F 2/958 Inflatable balloons for placing stents or stent-grafts
• CPC Class Codes: A61M 2025/105 having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes
• CPC Class Codes: A61M 2025/1084 having features for increasing the shape stability, the reproducibility or for limiting expansion, e.g. containments, wrapped around fibres, yarns or strands
• CPC Class Codes: A61M 25/104 used for angioplasty

Abstract

An angioplasty balloon having an elastic constraining structure that partially expands with the balloon so that, at maximum balloon inflation, the constraining structure forms a pattern of channels or “pillows” on the balloon.

Claims

1. A method for treating a lesion in a blood vessel, the method comprising:

inflating a balloon within the blood vessel; and

constraining inflation of said balloon by expanding at least one of a plurality of circumferentially spaced-apart axial struts crossing a multiplicity of axially spaced-apart radially expandable rings such that said balloon forms a plurality of isolated regions protruding from openings between said plurality of circumferentially spaced-apart axial struts crossing said multiplicity of axially spaced-apart radially expandable rings, the plurality of rings comprising a distal ring, a proximal ring, and an intermediate ring therebetween, wherein said plurality of isolated regions contact the lesion while said plurality of circumferentially spaced-apart axial struts crossing said multiplicity of axially spaced-apart radially expandable rings are recessed from a wall of the blood vessel and positioned within a plurality of recessed channels within the surface of the balloon, the plurality of recessed channels comprising a plurality of discrete circumferential recessed channels intersecting a plurality of axially extending recessed channels, thereby circumferentially treating the lesion in the blood vessel via said balloon.

2. A method as in claim 1, wherein said balloon is composed of a non-distensible or semi-compliant material and is inflated to a pressure in the range from 10 atm. to 25 atm.

3. A method as in claim 1, wherein said balloon is constrained by said plurality of circumferentially spaced-apart axial struts crossing said multiplicity of axially spaced-apart radially expandable rings to form at least 16 isolated protruding regions.

4. A method as in claim 1, wherein said balloon is coated with a drug that is transferred into the blood vessel wall as the balloon is inflated.

5. A method for treating a non-uniform lesion in a blood vessel, the method comprising:

inflating a balloon within a constraining structure comprising;

a plurality of axially spaced apart rings crossing a plurality of circumferentially spaced apart struts to form a plurality of openings, the plurality of rings comprising a distal ring, a proximal ring, and an intermediate ring therebetween, wherein inflating the balloon causes at least partial expansion of said constraining structure, the expanded constraining structure being recessed away from a wall of the blood vessel and positioned within a plurality of recessed channels, the plurality of recessed channels comprising a plurality of circumferentially spaced apart recessed channels extending axially across an entire length between the proximal ring and the distal ring and intersecting a plurality of discrete circumferential recessed channels, a surface of said inflated balloon forming a plurality of discrete regions which protrude from said openings to separately engage a segment of the lesion with a localized force and enable circumferential treatment of the lesion along its length via said balloon, and wherein a diameter of said balloon at said segment of the lesion is substantially similar to a diameter of said balloon at a non-lesion segment of the blood vessel.

6. A method as in claim 5, wherein said openings are formed by a plurality of circumferentially spaced-apart axial struts crossing a multiplicity of axially spaced-apart radially expandable rings.

7. A method as in claim 6, wherein said plurality of circumferentially spaced-apart axial struts crossing said multiplicity of axially spaced-apart radially expandable rings form quadrangular openings for allowing discrete regions of said balloon to protrude from said openings.

8. A method as in claim 5, wherein said balloon is formed from a non-distensible or semi-compliant material and is inflated to a pressure in the range from 10 atm to 25 atm.

9. A method as in claim 5, wherein said balloon is coated with a drug that is transferred into the blood vessel wall as the balloon is inflated.

10. A method as in claim 5, wherein said plurality of discrete regions have similar sizes and are uniformly distributed over the balloon surface.