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Method for analyzing methylation of a genome

  • US 9,200,316 B2
  • Filed: 01/30/2014
  • Issued: 12/01/2015
  • Est. Priority Date: 12/23/2008
  • Status: Active Grant
First Claim
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1. A method for analyzing methylation of a genome, comprising:

  • (a) cleaving a sample comprising DNA from the genome using an MspJI-family member to obtain DNA fragments that comprise a modified cytosine at a defined position that is within 30 nucleotides from either end of the fragments; and

    (b) obtaining sequence from either ends of the fragments produced in (a) to determine the defined position of the modified cytosine in the DNA fragments.

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