Blood pressure measuring device and method of calibrating thereof

• US 9,204,809 B2
• Filed: 02/01/2012
• Issued: 12/08/2015
• Est. Priority Date: 02/01/2012
• Status: Active Grant

• Current Assignee: Hong Kong Applied Science And Technology Research Institute Co., Ltd.
• Original Assignee: Hong Kong Applied Science And Technology Research Institute Co., Ltd.
• Inventors: Leung, Lap Wai Lydia, Gu, Wenbo, Zhang, Chun, Lam, Tun
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): WEARE, MEREDITH H
• Application Number:
  US13/364,297
• Publication Number:
  US 20120316448A1
• Time in Patent Office: 1,406 Days
• Field of Search: 600/486, 600490-507
• US Class Current: 1/1
• CPC Class Codes: A61B 2560/0223 of calibration, e.g. protocols for calibrating sensors
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 2562/066 in a matrix array
• CPC Class Codes: A61B 5/0082 adapted for particular medical purposes
• CPC Class Codes: A61B 5/02108 from analysis of pulse wave characteristics
• CPC Class Codes: A61B 5/0261 using optical means, e.g. infrared light
• CPC Class Codes: A61B 5/489 Blood vessels

Abstract

The present invention is a blood pressure measuring device comprising an optical sensing unit adapted for detecting optical pulses at a plurality of locations on an external surface of a user. The device also comprises a processing unit coupled to the optical sensing unit for determining an optimal location from the plurality of locations based on the detected optical pulses and a pressure sensing unit adapted for detecting a pressure pulse of the user at a location of measurement. The present invention also discloses a method of measuring a blood pressure of a user using a blood pressure measurement device. The advantage of the present invention is that by using an optical sensing unit to locate the artery of the user, or to compensate the misalignment from the artery, the blood pressure is more accurately determined. With the calibration method, the deficient cuff calibration can be waived in certain circumstances.

Claims

1. A method of operating a blood pressure measurement device adapted for measuring blood pressure on an external surface of a user, comprising the steps of:

a) determining an optimal location for calculating said blood pressure by a processing unit of said device based on a plurality of optical pulses and a plurality of pressure pulses obtained from an optical sensing unit and a pressure sensing unit of said device substantially simultaneously while applying a first constant external pressure by controlling an actuating unit of said device;

b) performing a cuff calibration to obtain parameters for said blood pressure calculation by said processing unit;

c) calculating said blood pressure based on an optical pulse, a pressure pulse and an optimal external pressure measured at a location of measurement which is aligned to said optimal location and said parameters for said blood pressure calculation by said processing unit, and

d) determining whether further cuff calibration is needed based on said pressure pulse at said location of measurement, said optimal external pressure and said optical pulse at said location of measurement by;

(1) comparing said pressure pulse at said location of measurement against a first threshold;

(2) comparing a percentage difference between said optimal external pressure and a reference external pressure against a second threshold;

(3) comparing a percentage difference between said optical pulse at said location of measurement and a reference optical pulse against a third threshold;

(4) comparing a ratio of a weighted combined amplitude of said optimal external pressure and said optical pulse at said location of measurement to a weighted combined amplitude of said reference external pressure and said reference optical pulse against a fourth threshold; and

(5) waiving said further cuff calibration if

i. said pressure pulse at said location of measurement is larger than said first threshold,

ii. said percentage difference between said optimal external pressure and said reference external pressure is less than said second threshold,

iii. said percentage difference between said optical pulse at said location of measurement and said reference optical pulse is less than said third threshold, and

iv. said ratio of weighted combined amplitude of said optimal external pressure and said optical pulse at said location of measurement to said weighted combined amplitude of said reference external pressure and said reference optical pulse is less than said fourth threshold.

2. The method according to claim 1, further comprising the step of determining whether said location of measurement is aligned to said optimal location.

3. The method according to claim 1, wherein said calculating step further comprises the step of adjusting a coefficient associated to said optical pulse at said location of measurement to compensate misalignment of said location of measure to said optimal location when said processing unit determines said location of measurement is not aligned to said optimal location.

4. The method according to claim 3, wherein said coefficient associated to said optical pulse is determined by cuff calibration.

5. The method according to claim 1, wherein said step of determining said optimal location for calculating said blood pressure further comprises the steps of

a) setting said actuating unit of said device to control said device to apply said first constant external pressure on said external surface across a plurality of locations;

b) obtaining said optical pulses at said plurality of locations from said optical sensing unit of said device and substantially simultaneously obtaining said pressure pulses at said plurality of locations from said pressure sensing unit of said device;

c) locating a location of interest that is corresponded to the highest amplitude optical pulse among said obtained optical pulses by said processing unit;

d) determining if said location of interest has a corresponding pressure pulse over a predetermined value by said processing unit;

e) setting said location of interest as said optimal location if said corresponding pressure pulse is over said predetermined value by said processing unit.

6. The method according to claim 1, further comprising the steps of applying a plurality of different external pressures onto said external surface at said optimal location by said actuating unit;

and further detecting an additional optical pulse and an additional pressure pulse at said optimal location for each of said plurality of different external pressures applied, and determines said optimal external pressure for said blood pressure measurement based on said additional optical pulses and said additional pressure pulses, wherein said optimal external pressure is one of said plurality of different external pressures applied at said optimal location at which said additional optical pulse is greater than a first predetermined threshold value and said additional pressure pulse is greater than a second predetermined threshold value.

7. A method of operating a blood pressure measurement device, comprising the steps of:

a) detecting a plurality of optical pulses on an external surface of a user by an optical sensing unit of said device;

b) determining an optimal condition for said blood pressure measurement based on said plurality of optical pulses;

c) detecting a pressure pulse at a location of measurement by a pressure sensing unit of said device; and

d) calculating said blood pressure based on said pressure pulse and said optimal condition,

wherein said step of determining said optimal condition comprises the steps of;

(1) determining an optimal location based on said optical pulses measured at a plurality of locations of said external surface of said user, and

(2) determining said optimal location based on said plurality of pressure pulses,

wherein the method of operating a blood pressure measurement device further comprises the step of determining whether cuff calibration is needed based on said pressure pulse at said location of measurement, an optimal external pressure and said optical pulse at said location of measurement, and said step of determining whether cuff calibration is needed comprises the steps of;

(1) comparing said pressure pulse at said location of measurement against a first threshold;

(2) comparing a percentage difference between said optimal external pressure and a reference external pressure against a second threshold;

(3) comparing a percentage difference between said optical pulse at said location of measurement and a reference optical pulse against a third threshold; and

(4) comparing a ratio of a weighted combined amplitude of said optimal external pressure and said optical pulse at said location of measurement to a weighted combined amplitude of said reference external pressure and said reference optical pulse against a fourth threshold; and

(5) waiving said cuff calibration if;

i. said pressure pulse at said location of measurement is larger than said first threshold,

ii. said percentage difference between said optimal external pressure and said reference external pressure is less than said second threshold,

iii. said percentage difference between said optical pulse at said location of measurement and said reference optical pulse is less than said third threshold, and

iv. said ratio of weighted combined amplitude of said optimal external pressure and said optical pulse at said location of measurement to said weighted combined amplitude of said reference external pressure and said reference optical pulse is less than said fourth threshold.

8. A blood pressure measurement device adapted for measuring blood pressure at an external surface of a user, comprising:

a) an optical sensing unit adapted for detecting an optical pulse at each of a plurality of locations on said external surface of said user;

b) an actuating unit adapted for actuating said device to move along said external surface and apply a plurality of different external pressures onto said external surface;

c) a pressure sensing unit adapted for detecting a pressure pulse of said user at each of said plurality of locations; and

d) a processing unit coupled to said optical sensing unit, said actuating unit and said pressure sensing unit,

wherein said processing unit is adapted for determining an optimal location for said device to measure said blood pressure by;

(1) setting said actuating unit to control said device to apply a first external pressure onto said external surface across said plurality of locations, wherein said first external pressure is constant;

(2) obtaining said optical pulse at each of said plurality of locations from said optical sensing unit and substantially simultaneously obtaining said pressure pulse at each of said plurality of locations from said pressure sensing unit;

(3) locating a location of interest that is corresponded to the highest amplitude optical pulse among said obtained optical pulses;

(4) determining if said location of interest has a corresponding pressure pulse over a predetermined value; and

(5) setting said location of interest as said optimal location if said corresponding pressure pulse is over said predetermined value,

wherein said device is adapted for measuring said blood pressure at a location of measurement which is aligned to said optimal location,

wherein said processing unit is further adapted for determining whether cuff calibration is needed based on said pressure pulse at said location of measurement, an optimal external pressure and an optical pulse at said location of measurement, wherein said step of determining whether cuff calibration is needed comprises the steps of;

(1) comparing said pressure pulse at said location of measurement against a first threshold;

(2) comparing a percentage difference between said optimal external pressure and a reference external pressure against a second threshold;

(3) comparing a percentage difference between said optical pulse at said location of measurement and a reference optical pulse against a third threshold; and

(4) comparing a ratio of a weighted combined amplitude of said optimal external pressure and said optical pulse at said location of measurement to a weighted combined amplitude of said reference external pressure and said reference optical pulse against a fourth threshold; and

(5) waiving said cuff calibration if;

i. said pressure pulse at said location of measurement is larger than said first threshold,

ii. said percentage difference between said optimal external pressure and said reference external pressure is less than said second threshold,

iii. said percentage difference between said optical pulse at said location of measurement and said reference optical pulse is less than said third threshold, and

iv. said ratio of weighed combined amplitude of said optimal external pressure and said optical pulse at said location of measurement to said weighted combined amplitude of said reference external pressure and said reference optical pulse is less than said fourth threshold.

9. The device according to claim 8, wherein said optical sensing unit comprises at least one optical emitter and at least one optical receiver spatially disposed adjacent to said at least one optical emitter.

10. The device according to claim 8, wherein said optical sensing unit is disposed on a different plane to said pressure sensing unit, said optical sensing unit being more proximal to said external surface of said user.

11. The device according to claim 8, wherein said optical sensing unit is disposed on a same plane as said pressure sensing unit.

12. The device according to claim 8, wherein said processing unit determines whether said location of measurement is aligned to said optimal location.

13. The device according to claim 12, wherein said processing unit adjusts a coefficient associated to said optical pulse at said location of measurement to compensate misalignment of said location of measure to said optimal location when said processing unit determines said location of measurement is not aligned to said optimal location.

14. The device according to claim 8, wherein said processing unit is further adapted for

a) performing a cuff calibration to obtain parameters for a blood pressure calculation;

and

b) calculating said blood pressure based on an optical pulse, a pressure pulse and an optimal external pressure measured at said location of measurement which is aligned to said optimal location and said parameters for blood pressure calculation.

15. The device according to claim 14, wherein said pressure sensing unit further detects said plurality of different external pressure applied by said device onto said external surface, said device further detects an additional optical pulse and an additional pressure pulse at said optimal location for each of said plurality of different external pressures applied, and determines said optimal external pressure for said blood pressure measurement based on said additional optical pulses and said additional pressure pulses, wherein said optimal external pressure is one of said plurality of different external pressures applied at said optimal location at which said additional optical pulse is greater than a first predetermined threshold value and said additional pressure pulse is greater than a second predetermined threshold value.