Multiple reservoir drug delivery device and methods
First Claim
1. A method of fixed time artificial insemination comprising:
- deploying a drug delivery device into a vaginal lumen of an animal subject, wherein the device comprises a housing containing (i) a first reservoir containing a first drug formulation comprising a gonadotropin-releasing hormone, (ii) a second reservoir containing a second drug formulation comprising a prostaglandin, (iii) a third reservoir containing a third drug formulation comprising a gonadotropin-releasing hormone, (iv) a porous membrane sidewall adjacent the vaginal lumen, and (v) one or more actuation systems configured to drive the first, second, and third drug formulations from the first, second, and third reservoirs;
thereafter driving the first drug formulation out of the first reservoir at a first time;
driving the second drug formulation out of the second reservoir at a second time, which is after the first time;
driving the third drug formulation out of the third reservoir at a third time, which is after the second time; and
artificially inseminating the animal subject at a fourth time, which is after the third time, wherein the porous membrane sidewall comprises a fluidic valve configured such that a critical threshold pressure from about 0.1 psi to about 100 psi is required to drive the first, second, and third drug formulations from the first, second, and third reservoirs to the vaginal lumen.
5 Assignments
0 Petitions
Accused Products
Abstract
Devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.
76 Citations
10 Claims
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1. A method of fixed time artificial insemination comprising:
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deploying a drug delivery device into a vaginal lumen of an animal subject, wherein the device comprises a housing containing (i) a first reservoir containing a first drug formulation comprising a gonadotropin-releasing hormone, (ii) a second reservoir containing a second drug formulation comprising a prostaglandin, (iii) a third reservoir containing a third drug formulation comprising a gonadotropin-releasing hormone, (iv) a porous membrane sidewall adjacent the vaginal lumen, and (v) one or more actuation systems configured to drive the first, second, and third drug formulations from the first, second, and third reservoirs; thereafter driving the first drug formulation out of the first reservoir at a first time; driving the second drug formulation out of the second reservoir at a second time, which is after the first time; driving the third drug formulation out of the third reservoir at a third time, which is after the second time; and artificially inseminating the animal subject at a fourth time, which is after the third time, wherein the porous membrane sidewall comprises a fluidic valve configured such that a critical threshold pressure from about 0.1 psi to about 100 psi is required to drive the first, second, and third drug formulations from the first, second, and third reservoirs to the vaginal lumen. - View Dependent Claims (2, 3, 4)
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5. A method of fixed time artificial insemination comprising:
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deploying a drug delivery device into a vaginal lumen of an animal subject, wherein the device comprises a housing containing (i) a first reservoir containing a first drug formulation comprising a gonadotropin-releasing hormone, (ii) a second reservoir containing a second drug formulation comprising a prostaglandin, (iii) a third reservoir containing a third drug formulation comprising a gonadotropin-releasing hormone, (iv) a porous membrane sidewall adjacent the vaginal lumen, and (v) one or more actuation systems configured to drive the first, second, and third drug formulations from the first, second, and third reservoirs; thereafter driving the first drug formulation out of the first reservoir at a first time; driving the second drug formulation out of the second reservoir at a second time, which is after the first time; driving the third drug formulation out of the third reservoir at a third time, which is after the second time; and artificially inseminating the animal subject at a fourth time, which is after the third time, wherein the porous membrane sidewall substantially surrounds the housing about the first, second, and third reservoirs. - View Dependent Claims (6, 7, 8, 9, 10)
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Specification