System for performing remote ischemic conditioning

• US 9,205,019 B2
• Filed: 06/12/2014
• Issued: 12/08/2015
• Est. Priority Date: 04/15/2011
• Status: Expired

• Current Assignee: CellAegis Devices, Inc.
• Original Assignee: CellAegis Devices, Inc.
• Inventors: Ganske, Rocky Eugene, Gil, Lahav, Shepperdley, Adam, Cracauer, Raymond, Royblat, Igal, Christensen, Kristopher Thomas, Gadzic, Rade, Caldarone, Christopher, Redington, Andrew
• Primary Examiner(s): HOLWERDA, KATHLEEN SONNETT
• Application Number:
  US14/302,624
• Publication Number:
  US 20140296756A1
• Time in Patent Office: 544 Days
• Field of Search: 606201-204, 600490-496
• US Class Current: 1/1
• CPC Class Codes: A61B 17/1325 with means for applying local pressure pressure pads A61F5/30
• CPC Class Codes: A61B 17/1355 Automated control means therefor
• CPC Class Codes: A61B 2017/00123 and automatic shutdown
• CPC Class Codes: A61B 2017/00477 Coupling A61B2017/0046 takes precedence
• CPC Class Codes: A61B 2017/00858 high friction or non-slip
• CPC Class Codes: A61B 2090/065 for measuring contact or contact pressure
• CPC Class Codes: A61B 5/02233 Occluders specially adapted therefor tourniquets A61B17/132
• CPC Class Codes: A61H 2201/0107 modular
• CPC Class Codes: A61H 2201/0176 By stopping operation
• CPC Class Codes: A61H 2201/0184 by raising an alarm
• CPC Class Codes: A61H 2201/165 Wearable interfaces
• CPC Class Codes: A61H 2201/501 connected to external computer devices or networks
• CPC Class Codes: A61H 2201/5035 Several programs selectable
• CPC Class Codes: A61H 2201/5038 freely programmable by the user
• CPC Class Codes: A61H 2201/5041 control is restricted to certain individuals
• CPC Class Codes: A61H 2201/5043 Displays
• CPC Class Codes: A61H 2201/5071 Pressure sensors
• CPC Class Codes: A61H 2201/5097 wireless
• CPC Class Codes: A61H 2230/305 used as a control parameter for the apparatus A61H2230/045 takes precedence
• CPC Class Codes: A61H 9/0078 with intermittent or alternately inflated bladders or cuffs mattresses for preventing bed-sores with alternated pressurized chambers A61G7/05776
• CPC Class Codes: A61H 9/0092 : Cuffs therefor

Abstract

A system for performing remote ischemic conditioning includes an inflatable cuff configured to encircle a limb of a subject and a controller removably attached to the cuff. The controller includes a pump; a manifold in fluid communication with the pump; a connector in fluid communication with the manifold and in removable fluid communication with the inflatable cuff; a pressure sensor; and a control circuit configured to implement a remote ischemic conditioning treatment protocol.

Claims

1. A device for remote ischemic conditioning comprising:

an inflatable cuff configured to encircle a limb of a subject;

a controller removably attached to the cuff, wherein the controller comprises;

a manifold configured to provide fluid communication between the controller and the cuff;

an outlet in fluid communication with the manifold and in removable fluid communication with the inflatable cuff; and

a control circuit configured to implement a remote ischemic conditioning treatment protocol; and

a controller attachment section joined to the cuff, the controller attachment section having a bottom surface that substantially conforms to an outer surface of the cuff, wherein the controller is removably attached to the cuff by selective attachment to the controller attachment section disposed on the cuff, the controller attachment section further comprising;

an upper surface for supporting the controller in an attached state;

an upstanding wall surrounding the upper surface;

a tab mounted at one end of the upper surface and including a projecting edge spaced from the upper surface, the projecting edge facing outwardly toward the upstanding wall; and

bosses disposed on the upstanding wall on the opposite side of the controller attachment section from the tab;

wherein the controller further comprises a slot that is disposed between a body of the controller and an outer band, and wherein the device is arranged such that when the controller is attached to the controller attachment section, an upper portion of the tab is pushed inwardly away from the upstanding wall so that the tab passes through the slot, and the bosses extend into corresponding recesses provided in the controller body.

2. The device of claim 1, wherein the controller attachment section further includes a conduit that provides sealed, fluid communication between the controller and inflatable cuff.

3. The device of claim 1, wherein cuff pressure is controllable by selectively opening a valve of the controller in response to a command from control circuitry of the control circuit.

4. The device of claim 3, wherein the controller attachment section provides fluid communication between the controller and a bladder of the cuff via a structure that includes a conduit that has a female section constructed and arranged to mate with the controller outlet and a male section that is constructed and arranged to mate with a valve of the bladder of the cuff.

5. The device of claim 1, wherein:

an axial direction of the cuff is substantially parallel to an axis of the limb when the cuff is in a fitted state;

the controller attachment section is operatively attached to the cuff by at least one attachment joint oriented substantially parallel to the axial direction of the cuff; and

the controller attachment section provides fluid communication between the controller and the cuff.

6. The device of claim 1, wherein the controller comprises a slow continuous relief valve that continually releases gas from the cuff at a flow rate lower than a flow rate of the gas being introduced into the cuff.

7. The device of claim 1, wherein the controller further comprises at least one valve configured to open in response to an overpressure event, or in response to an error command from the control circuit.

8. The device of claim 7, wherein the valve opens in response to a command from the controller when a specified condition is detected.

9. The device of claim 1, wherein the control circuit maintains a cuff pressure between pre-selected pressure limits during an ischemic duration of the remote ischemic conditioning treatment protocol.

10. A device for remote ischemic conditioning comprising:

an inflatable cuff configured to encircle a limb of a subject;

a controller removably attached to the cuff, wherein the controller comprises;

a manifold configured to provide fluid communication between the controller and the cuff;

an outlet in fluid communication with the manifold and in removable fluid communication with the inflatable cuff; and

a control circuit configured to implement a remote ischemic conditioning treatment protocol; and

a controller attachment section joined to the cuff, the controller attachment section having a bottom surface that substantially conforms to an outer surface of the cuff, wherein the controller is removably attached to the cuff by selective attachment to the controller attachment section disposed on the cuff;

wherein cuff pressure is controllable by selectively opening a valve of the controller in response to a command from control circuitry of the control circuit;

wherein the controller attachment section provides fluid communication between the controller and a bladder of the cuff via a structure that includes a conduit that has a female section constructed and arranged to mate with the controller outlet and a male section that is constructed and arranged to mate with a valve of the bladder of the cuff; and

wherein the controller outlet has an outer dimension at an end spaced from the controller, and the female section of the conduit has an upper opening that is configured to receive the end of the controller outlet, a cross-sectional size of the upper opening of the female section being greater than the outer dimension of the controller outlet and greater than an inner dimension of the male section.

11. The device of claim 10, further comprising an O-ring seal disposed within the upper opening of the female section, the O-ring seal surrounding and sealing the controller outlet when disposed within the female section.

12. The device of claim 11, wherein a mouth of the upper opening of the female section includes a retaining structure that has an upper surface that forms an acute angle with respect to a direction of elongation of the controller outlet.