Light-absorbing compositions and methods of use

• US 9,205,284 B2
• Filed: 08/09/2011
• Issued: 12/08/2015
• Est. Priority Date: 08/09/2010
• Status: Active Grant

• Current Assignee: Allele Biotechnology & Pharmaceuticals, Inc.
• Original Assignee: Allele Biotechnology & Pharmaceuticals, Inc.
• Inventors: Wang, Jiwu
• Primary Examiner(s): Skowronek, Karlheinz R
• Assistant Examiner(s): Lee, Jia-Hai
• Application Number:
  US13/206,420
• Publication Number:
  US 20120093737A1
• Time in Patent Office: 1,582 Days
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/434 Luminescent, Fluorescent; Optical brighteners; Photosensitizers
• CPC Class Codes: A61K 8/64 Proteins; Peptides; Derivatives or degradation products thereof
• CPC Class Codes: A61K 8/987 of species other than mammals or birds
• CPC Class Codes: A61Q 17/04 Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
• CPC Class Codes: C07K 14/43504 from invertebrates

Abstract

The present disclosure relates to methods and compositions comprising naturally occurring light absorbing molecules for preventing damages from light exposure. Specific embodiments of this disclosure include fluorescent proteins from Brachiostoma lanceolatum.

Claims

1. A polypeptide comprising SEQ ID No 3 in a formulation suitable for topical application.

2. A polypeptide comprising SEQ ID No 4 in a formulation suitable for topical application.

3. A method for protecting the state of the skin from light damage in a subject in need thereof, said method comprises topically administering a composition comprising a dermatologically acceptable carrier or a vehicle and a Brachiostoma light absorbing polypeptide having the peptide sequence of SEQ ID No 3 formulated for topical administration.

4. A method for protecting the state of the skin from light damage in a subject in need thereof, said method comprises topically administering a composition comprising a dermatologically acceptable carrier or a vehicle and a Brachiostoma light absorbing polypeptide having the peptide sequence of SEQ ID No 4 formulated for topical administration.

5. The method of claim 3 or 4, wherein the method protects the skin of a subject from UV- and/or non-UV light induced disease or disorder.

6. The method according to claim 3, wherein the method comprises topically administering a composition—

comprising a polypeptide having the peptide sequence of SEQ ID No 3 in a formulation suitable for skin application onto a subject in need thereof.

7. The method according to claim 3, wherein the method comprises topically administering a composition—

comprising a polypeptide having the peptide sequence of SEQ ID No 4 in a formulation suitable for skin application onto a subject in need thereof.

8. The method according to claim 3 or 4, wherein the composition comprises a lotion, an ointment, a gel, a cream, a water in oil or oil in water emulsion, a shampoo, a moisturizer, a sunscreen, a cream, a stick, a spray, an aerosol, foam, a paste, a mousse, a solid, semi-solid, or a liquid make-up, a foundation, and an eye make-up.

9. The method according to claim 3 or 4, wherein the composition further comprises at least one additive selected from a diluent, a preservative, an abrasive, an anticaking agent, an antistatic agent, a binder, a buffer, a dispersant, an emollient, an emulsifier, a co-emulsifiers, a fibrous material, a film forming agent, a fixative, a foaming agent, a foam stabilizer, a foam booster, a gellant, a lubricant, a moisture barrier agent, a plasticizer, a preservative, a propellant, a stabilizer a surfactant, a suspending agent, a thickener, a wetting agent, and a liquefier.

10. The method according to claim 3 or 4, wherein the composition further comprises at least one additive selected from an anti-acne agent, an anti-aging agent, an antibacterial agent, an anti-cellulites agent, an antidandruff agent, an antifungal agent, an anti-inflammatory agent, an anti-irritation agent, an antimicrobial agent, an antioxidant agent, an antiperspirant agent, an antiseptic agent, a cell stimulant, a cleansing agent, a conditioner, a deodorant, a depilatory, a detergent, an enzyme, an essential oil, an exfoliant, a fungicide, a glosser, hair conditioner, hair set resin, hair sheen agent, hair waving agent, a humectants, a moisturizer, an ointment base, a perfume, a protein, a skin calming agent, a skin cleanser, a skin conditioner, a skin healing agent, a skin lightening agent, a skin protectant, a skin smoothing agent, a skin softening agent, a skin soothing agent, a sunscreen agent, a tanning accelerator, vitamins, a colorant, and a flavoring agent.