Method for performing a physiological analysis with increased reliability

• US 9,211,080 B2
• Filed: 11/12/2012
• Issued: 12/15/2015
• Est. Priority Date: 11/21/2011
• Status: Expired due to Fees

• Current Assignee: Impeto Medical Incorporated
• Original Assignee: Impeto Medical Incorporated
• Inventors: Brunswick, Philippe
• Primary Examiner(s): Kahelin, Michael
• Assistant Examiner(s): Alter, Mitchell E
• Application Number:
  US14/359,503
• Publication Number:
  US 20140330096A1
• Time in Patent Office: 1,128 Days
• Field of Search: 600/307, 600/383, 600/384, 600/547
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0531 Measuring skin impedance
• CPC Class Codes: A61B 5/4266 sweat secretion
• CPC Class Codes: A61B 5/6814 Head
• CPC Class Codes: A61B 5/6825 Hand
• CPC Class Codes: A61B 5/6829 Foot or ankle
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424

Abstract

A method for performing an electrophysiological analysis implemented in a system includes: a series of electrodes to be placed on different regions of the human body; a DC voltage source controlled so as to produce DC voltage pulses; a switching circuit for selectively connecting the active electrodes to the voltage source, the active electrodes forming an anode and a cathode, and for connecting at least one other high-impedance passive electrode used to measure the potential reached by the body; and a measuring circuit for reading data representative of the current in the active electrodes, and data representative of the potentials generated on at least certain high-impedance electrodes in response to the application of the pulses, the data allowing a value to be determined for the electrochemical conductance of the skin. The method also regenerates a high-impedance electrode connected to the voltage source as a cathode.

Claims

1. An electrophysiological analysis method applied in a system comprising:

a series of electrodes including active and passive electrodes configured to be placed in different regions of a human body,

a DC voltage source, controlled for increasing DC voltage square wave pulses,

a switching circuit selectively connecting a pair of the active electrodes to the voltage source, the active electrodes forming an anode and a cathode, and the switching circuit connecting at least one of the passive electrodes with impedance being used for measuring potential attained by the body, and

a measuring circuit measuring representative data of current in the active electrodes and potentials on at least certain electrodes connected with impedance in response to the application of the square waves, the data allowing determination of a value of electrochemical conductance of skin,

the method further comprising;

at least one measuring step during which the adjustable voltage source applies to the anode a series of the DC voltage square waves, and during which the measuring circuit measures the data,

a step prior to the measuring step, during which an electrode which is connected with impedance during the measuring step is regenerated by being connected to the voltage source as a cathode; and

an intermediate step, between the regeneration step and the measuring step, during which a voltage difference is measured between a non-regenerated electrode connected with impedance and a regenerated electrode connected with impedance, the difference allowing determination of an overvoltage value at the non-regenerated electrode, and wherein, during the measuring step, the non-regenerated electrode, the overvoltage of which has been measured, is connected as an anode.

2. The electrophysiological analysis method according to claim 1, wherein, during the regeneration step, the cathode is subject to a DC potential comprised between −

1 and −

4V.

3. The electrophysiological analysis method according to claim 1, wherein, during the regeneration step, the voltage source delivers a voltage square wave pulse with a duration comprised between 5 seconds and one minute.

4. The electrophysiological analysis method according to claim 1, wherein, during the regeneration step, the voltage source delivers square wave pulses with an identical or variable voltage from one pulse to the other.

5. The electrophysiological analysis method according to claim 4, wherein the cumulative duration of the square wave pulses is comprised between 5 seconds and one minute.

6. The electrophysiological analysis method according to claim 1, wherein, during a regeneration step, the measuring circuit measures the representative data of the current in the active electrodes, of their potentials, and of the potentials on at least certain electrodes connected in impedance.

7. The electrophysiological analysis method according to claim 1, comprising an additional regeneration step prior to the measuring step, during which another electrode connected with impedance during the measuring step is regenerated while being connected to the voltage source as a cathode.

8. The electrophysiological analysis method according to claim 7, comprising a step for calculating the average of the potentials of the regenerated electrodes connected with impedance.

9. The electrophysiological analysis method according to claim 1, wherein the applied voltage square wave pulses during the measuring step have a duration of greater than or equal to 0.2 seconds.

10. The electrophysiological analysis method according to claim 1, wherein the DC voltage applied to the anode is less than 10 V.

11. The electrophysiological analysis method according to claim 1, wherein the voltage source during the measuring step delivers square wave pulses with variable voltages from one pulse to the other.

12. The electrophysiological analysis method according to claim 1, wherein each electrode is positioned on an area from among the following group:

the right hand, left hand, right foot, left foot, right side of the forehead, left side of the forehead.

13. The electrophysiological analysis method according to claim 1, wherein the electrochemical conductance of the skin at the anode and at the cathode is calculated by a processor from data respectively measured at the anode and at the cathode, and showing a curve on a display connected to the processor.

14. The electrophysiological analysis method according to claim 1, comprising a step for determining from the overvoltage of the non-regenerated high impedance electrode, a correction to be applied to the values measured during the measuring step.

15. The electrophysiological analysis method according to claim 14, wherein the regenerated electrode connected with impedance during the intermediate step was connected beforehand as a cathode, and comprising a step in which the overvoltage determined during the intermediate step is subtracted from the potential measured at the anode during the measuring step.

16. The electrophysiological analysis method according to claim 1, comprising an additional regeneration step, between the regeneration step and the measuring step, during which the anode and the cathode are respectively the same as those of the measuring step.

17. The electrophysiological analysis method according to claim 1, wherein the cumulative duration of the square wave voltage pulses applied during the measuring step is comprised between 10 and 30 seconds.

18. The electrophysiological analysis method according to claim 17, wherein the cumulative duration of the square wave voltage pulses applied during the measuring step is greater than or equal to the duration of the applied square wave during a regeneration step.

19. The electrophysiological analysis method according to claim 18, wherein an overvoltage at the anode is estimated by the value of the potential at the anode extrapolated to when the current becomes zero, and the conductance of the skin at the anode is obtained by dividing the current measured at the anode by the difference between the potential of the anodes subtracted with the overvoltage and the potential of a regenerated electrode connected with impedance.

20. The electrophysiological analysis method according to claim 18, wherein the square wave pulses applied during the measuring step are of increasing or decreasing voltage from one pulse to the other, and the conductance of the skin at the anode is determined by measuring the slope of the current-voltage curve are measured at the anode for voltages of less than 2 V.

21. The electrophysiological analysis method according to claim 1, comprising at least one additional regeneration step, prior to the measuring step, during which the electrode used as an anode during the measuring step is a regenerated by being connected to the voltage source as a cathode.

22. The electrophysiological analysis method according to claim 21, comprising a cycle of electrode regeneration steps and of measuring steps, wherein, for each measuring step, the anode and at least one electrode connected with impedance were regenerated during at least two regeneration or measuring steps.

23. The electrophysiological analysis method according to claim 22, wherein the cathode used during a measuring step is switched to as an anode during a subsequent measuring step.

24. The electrophysiological analysis method according to claim 23, system comprises four electrodes, and wherein for each measuring step, the anode and the two electrodes connected with impedance were regenerated during the regeneration or the measuring steps.

26. A method for modeling the electric conductance of walls of eccrine sweat glands, comprising applying the method according to claim 1 with the electrodes positioned in the region of the relevant eccrine glands.

25. An electrophysiological analysis method for use in a system comprising:

a series of electrodes configured to be placed in different regions of a human body,

a DC voltage source controlled for increasing DC voltage square wave pulses,

a switching circuit selectively connecting a pair of active electrodes to the voltage source, the active electrodes forming an anode and a cathode, and the switch circuit connecting at least one of the passive electrode with impedance being used for measuring potential attained by the body, and

a measuring circuit measuring representative data of current in the active electrodes and potentials on at least certain electrodes connected with impedance in response to the application of the square waves, the data allowing determination of a value of the electrochemical conductance of skin,

the method further comprising;

at least one measuring step during which the adjustable voltage source applies to the anode a series of the DC voltage square waves, and during which the measuring circuit measures the data,

a step prior to the measuring step, during which an electrode which is connected with impedance during the measuring step is regenerated by being connected to the voltage source as a cathode; and

measuring a conductance of the skin at the anode by dividing the current measured at the anode by the potential difference between the anode, the overvoltage having been subtracted therefrom, and a regenerated electrode connected with impedance, and wherein the thereby obtained electrochemical conductance of the skin corresponds to electric conductance of walls of eccrine sweat glands in contact with the active electrodes.