Optical blood glucose detecting apparatus and operating method thereof

• US 9,211,089 B2
• Filed: 03/15/2012
• Issued: 12/15/2015
• Est. Priority Date: 03/15/2011
• Status: Expired due to Fees

• Current Assignee: Crystalvue Medical Corporation
• Original Assignee: Crystalvue Medical Corporation
• Inventors: Yen, Meng-Shin, Wang, William, Chou, Chung-Cheng, Chuang, Chung-Ping
• Primary Examiner(s): Chen, Tse
• Assistant Examiner(s): Liu, Chu Chuan (JJ)
• Application Number:
  US13/421,290
• Publication Number:
  US 20120238843A1
• Time in Patent Office: 1,370 Days
• Field of Search: 600/310, 600/316, 600/322, 600/331, 600/344, 600/473, 600/476, 600/333
• US Class Current: 1/1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters

Abstract

An optical blood glucose detecting apparatus and an operating method thereof are disclosed. The optical blood glucose detecting apparatus includes a detecting module, an assisting and strengthening module, and a data processing module. The detecting module provides an incident optical signal passing through a detected portion of skin surface into a skin interstitial fluid, captures a blood glucose optical reflection message of the skin interstitial fluid, and it interferes the blood glucose optical reflection message and the incident optical signal to generate a detected data. The assisting and strengthening module provides a physical or chemical effect on a tissue region under the detected portion to strengthen the blood glucose optical reflection message. The data processing module processes the detected data to determine a blood glucose concentration.

Claims

1. An optical blood glucose detecting apparatus, comprising:

a detecting module, configured to select a detected portion of a skin surface according to characteristic points on the skin surface, provide an incident optical signal to pass through the detected portion of the skin surface into a skin interstitial fluid, capture a blood glucose optical reflection message of the skin interstitial fluid, and interfere the blood glucose optical reflection message and the incident optical signal to generate a detected data, wherein the skin interstitial fluid comprises a chloride ion, a sodium ion, a water, and a glucose, and a blood glucose concentration in the skin interstitial fluid is uneven;

an assisting and strengthening module, comprising;

an electrode, disposed on the detected portion of the skin surface and configured to selectively provide a low current to the skin interstitial fluid under the detected portion of the skin surface to make the chloride ion and the sodium ion in the skin interstitial fluid move toward the electrode, and the water and the glucose being taken out with the chloride ion and the sodium ion to make the blood glucose concentration in the skin interstitial fluid become uniform; and

a data processing module, coupled to the detecting module and the assisting and strengthening module and configured to process the detected data according to a plurality of default blood glucose concentrations stored in a blood glucose concentration database to determine a value of the blood glucose concentration and configured to determine whether the detected portion of the skin surface is properly selected by the detecting module or not according to a number of times assisting and strengthening processes are needed to achieve a specific blood glucose concentration, when the number of times of the assisting and strengthening processes needed to achieve the specific blood glucose concentration is larger than a default number of times, the data processing module being configured to determine that the detected portion of the skin surface is not properly selected by the detecting module, and then the detecting module selecting another detected portion for detection;

wherein the blood glucose concentration database is configured to store a plurality of default blood glucose concentrations which are assisted and strengthened, the data processing module is configured to compare the blood glucose concentration after being assisted and strengthened with the plurality of default blood glucose concentrations in the blood glucose concentration database to determine whether the detected portion is properly selected.

2. A method of operating an optical blood glucose detecting apparatus, the optical blood glucose detecting apparatus comprising a detecting module, an assisting and strengthening module, and a data processing module, the assisting and strengthening module comprising an electrode, the method comprising steps of:

(a) the detecting module selecting a detected portion of a skin surface according to characteristic points on the skin surface, providing an incident optical signal to pass through the detected portion of the skin surface into a skin interstitial fluid, capture a blood glucose optical reflection message of the skin interstitial fluid, and interfere the blood glucose optical reflection message and the incident optical signal to generate a detected data, wherein the skin interstitial fluid comprises a chloride ion, a sodium ion, a water, and a glucose, and a blood glucose concentration in the skin interstitial fluid is uneven;

(b) disposing the electrode on the detected portion of the skin surface and the electrode selectively providing a low current to the skin interstitial fluid under the detected portion of the skin surface to make the chloride ion and the sodium ion in the skin interstitial fluid move toward the electrode, and the water and the glucose being taken out with the chloride ion and the sodium ion to make the blood glucose concentration in the skin interstitial fluid become uniform; and

(c) the data processing module processing the detected data according to a plurality of default blood glucose concentrations stored in a blood glucose concentration database to determine a value of the blood glucose concentration and determining whether the detected portion of the skin surface is properly selected by the detecting module or not according to a number of times assisting and strengthening processes are needed to achieve a specific blood glucose concentration, when the number of times of the assisting and strengthening processes needed to achieve the specific blood glucose concentration is larger than a default number of times, the data processing module determining that the detected portion of the skin surface is not properly selected by the detecting module, and then the detecting module selecting another detected portion for detection;

wherein the blood glucose concentration database stores a plurality of default blood glucose concentrations which are assisted and strengthened, the data processing module compares the blood glucose concentration after being assisted and strengthened with the plurality of default blood glucose concentrations in the blood glucose concentration database to determine whether the detected portion is properly selected.