Antibiotic kit and composition and uses thereof

• US 9,211,259 B2
• Filed: 06/07/2006
• Issued: 12/15/2015
• Est. Priority Date: 11/29/2002
• Status: Active Grant

• Current Assignee: VYNE Therapeutics, Inc.
• Original Assignee: Foamix Pharmaceuticals, Ltd. (VYNE Therapeutics, Inc.)
• Inventors: Friedman, Doron, Besonov, Alex, Tamarkin, Dov, Eini, Meir
• Primary Examiner(s): Blanchard, David J
• Assistant Examiner(s): THAKOR, DEVANG K
• Application Number:
  US11/448,490
• Publication Number:
  US 20060269485A1
• Time in Patent Office: 3,478 Days
• Field of Search: 424/45
• US Class Current: 1/1
• CPC Class Codes: A61K 47/06 Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
• CPC Class Codes: A61K 47/10 Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
• CPC Class Codes: A61K 47/14 Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
• CPC Class Codes: A61K 9/107 Emulsions ; Emulsion preconcentrates; Micelles composition of emulsions A61K47/00
• CPC Class Codes: Y02A 50/30 Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The present invention relates to a therapeutic kit to provide a safe and effective dosage of an antibiotic agent, including an aerosol packaging assembly including: a container accommodating a pressurized product; and an outlet capable of releasing the pressurized product as a foam, wherein the pressurized product comprises a foamable composition including: an antibiotic agent; at least one organic carrier selected from the group consisting of a hydrophobic organic carrier, an organic polar solvent, an emollient and mixtures thereof, at a concentration of about 2% to about 50% by weight, a surface-active agent, about 0.01% to about 5% by weight of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent, water; and liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the total composition.

Claims

1. A method of treating or alleviating disorders of a skin, body cavity or mucosal surface, wherein the disorder involves inflammation as one of its etiological factors, the method comprising:

a. releasing a foamable composition from an aerosol container to form an expanded thermally stable foam that collapses upon application of mechanical force, said foamable composition comprising a propellant and a composition, said composition comprising;

i. an antibiotic agent;

ii. a therapeutically active oil comprising about 10% to about 50% by weight of the composition of a capric/caprylic triglyceride;

iii. a surface-active agent;

iv. about 0.01% to about 5% by weight of the composition of at least one polymeric additive selected from the group consisting of a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and

v. water;

wherein the propellant comprises a liquefied or compressed gas propellant at a concentration of about 3% to about 25% by weight of the foamable composition

b. administering the foam to a target area having a disorder of the skin, body cavity or mucosa; and

c. collapsing the foam by applying mechanical force, wherein the foam is absorbed onto the target area,

wherein the antibiotic agent is administered in a therapeutically effective amount;

wherein the composition contains less than 5% by weight of the composition of short chain alcohols having up to 5 carbon atoms in their carbon chain skeleton and one hydroxyl group; and

wherein the composition is a thermally stable breakable foam.

2. The method of claim 1, wherein the foamable composition is selected from the group consisting of an oil-in-water emulsion and a water-in-oil emulsion.

3. The method of claim 1, wherein the aerosol container includes an outlet, which comprises a valve, containing a stem with 1 to 4 apertures formed in the stem.

4. The method of claim 3, wherein each aperture formed in the stem has a diameter, selected from the group consisting of (i) about 0.2 mm to about 1 mm;

(ii) about 0.3 mm to about 0.8 mm; and

(iii) about 0.01 mm and 1 mm.

5. The method of claim 3, wherein the sum of cross-sectional areas of all apertures in the stem is between about 0.04 mm² and 0.5 mm².

6. The method of claim 3, wherein the valve is attached to metered dose device.

7. The method of claim 1, wherein the foamable composition contains less than 2% by weight of the composition of short chain alcohols having up to 5 carbon atoms in their carbon chain skeleton and one hydroxyl group.

8. The method of claim 1, wherein the concentration range of the antibiotic agent is selected from the group of (i) between about 0.005% and about 0.5% by weight of the composition;

(ii) between about 0.5% and about 2% by weight of the composition;

(iii) between about 2% and about 5% by weight of the composition; and

(iv) between about 5% and about 12% by weight of the composition.

9. The method of claim 1, wherein the composition further comprises a vasodilator.

10. The method of claim 1, wherein upon release, foam, having a density range selected from (1) between about 0.01 gr/mL and about 0.1 gr/mL;

and (2) between about 0.02 gr/ mL and about 0.1 gr/mL, is produced.

11. The method of claim 2, wherein the graded of solubility of the antibiotic agent in the aqueous phase of the emulsion is selected from the groups consisting of:

(i) less than 1 parts of solvent required for 1 part of solute;

(ii) from 1 to 10 parts of solvent required for 1 part of solute;

(iii) from 10 to 30 parts of solvent required for 1 part of solute;

(iv) from 30 to 100 parts of solvent required for 1 part of solute;

(v) from 100 to 1000 parts of a solvent required for 1 part of solute; and

(vi) 10,000 parts or more of a solvent required for 1 part of solute.

12. The method of claim 2, wherein the antibiotic agent is dissolved in at least one phase of the emulsion.

13. The method of claim 1, wherein the surface active agent includes a mixture of at least one non-ionic surfactant and at least one ionic surfactant in a ratio in the range of about 100:

1 to 1;

1.

14. The method of claim 1, wherein the surface active agent comprises a combination of a non-ionic surfactant and an ionic surfactant, at a ratio of between 1:

1 and 20;

1.

15. The method of claim 1, wherein the surface active agent consists essentially of a non-ionic surfactant.

16. The method of claim 2, wherein the emulsion is selected from:

i. an oil-in-water emulsion and wherein the HLB range of the surface active agent is between about 9 and about 14; and

ii. a water-in-oil emulsion and wherein the HLB range of the surface active agent is between about 2 and about 9.

17. The method of claim 1, further including about 0.1% to about 5% by weight of the composition of a therapeutically active foam adjuvant is selected from the group consisting of fatty alcohols having 15 or more carbons in their carbon chain;

fatty acids having 16 or more carbons in their carbon chain;

fatty alcohols derived from beeswax and including a mixture of alcohols, a majority of which has at least 20 carbon atoms in their carbon chain;

fatty alcohols having at least one double bond;

fatty acids having at least one double bond;

branched fatty alcohols;

branched fatty acids;

fatty acids substituted with a hydroxyl group;

cetyl alcohol;

stearyl alcohol;

arachidyl alcohol;

behenyl alcohol;

1-triacontanol;

hexadecanoic acid;

stearic acid;

arachidic acid;

behenic acid;

octacosanoic acid;

12-hydroxy stearic acid, and mixtures of any two or more thereof.

18. The method of claim 1, wherein the concentration of the surface active agent is between about 0.1% and about 5% by weight of the composition.

19. The method of claim 1 or 17, wherein the antibiotic agent is selected from the group consisting of beta-lactam antibiotics, aminoglycosides, ansa-type antibiotics, anthraquinones, antibiotic azoles, antibiotic glycopeptides, macrolides, antibiotic nucleosides, antibiotic peptides, antibiotic polyenes, antibiotic polyethers, quinolones, antibiotic steroides, sulfonamides, tetracycline, dicarboxylic acids, antibiotic metals, oxidizing agents, substances that release free radicals and/or active oxygen, cationic antimicrobial agents, quaternary ammonium compounds, biguanides, triguanides, bisbiguanides and analogs and polymers thereof, naturally occurring antibiotic compounds, and mixtures of any two or more thereof.

20. The method of claim 19, wherein the antibiotic agent is selected from the group consisting of:

i. a beta-lactam, selected from the group consisting of 2-(3-alanyl)clavam, 2-hydroxymethylclavam, 8-epi-thienamycin, acetyl-thienamycin, amoxicillin, amoxicillin sodium, amoxicillin trihydrate, amoxicillin-potassium clavulanate combination, ampicillin, ampicillin sodium, ampicillin trihydrate, ampicillin-sulbactam, apalcillin, aspoxicillin, azidocillin, azlocillin, aztreonam, bacampicillin, biapenem, carbenicillin, carbenicillin disodium, carfecillin, carindacillin, carpetimycin, cefacetril, cefaclor, cefadroxil, cefalexin, cefaloridine, cefalotin, cefamandole, cefamandole, cefapirin, cefatrizine, cefatrizine propylene glycol, cefazedone, cefazolin, cefbuperazone, cefcapene, cefcapene pivoxil hydrochloride, cefdinir, cefditoren, cefditoren pivoxil, cefepime, cefetamet, cefetamet pivoxil, cefixime, cefmenoxime, cefmetazole, cefminox, cefminox, cefmolexin, cefodizime, cefonicid, cefoperazone, ceforanide, cefoselis, cefotaxime, cefotetan, cefotiam, cefoxitin, cefozopran, cefpiramide, cefpirome, cefpodoxime, cefpodoxime proxetil, cefprozil, cefquinome, cefradine, cefroxadine, cefsulodin, ceftazidime, cefteram, cefteram pivoxil, ceftezole, ceftibuten, ceftizoxime, ceftriaxone, cefuroxime, cefuroxime axetil, cephalosporin, cephamycin, chitinovorin, ciclacillin, clavulanic acid, clometocillin, cloxacillin, cycloserine, deoxy pluracidomycin, dicloxacillin, dihydro pluracidomycin, epicillin, epithienamycin, ertapenem, faropenem, flomoxef, flucloxacillin, hetacillin, imipenem, lenampicillin, loracarbef, mecillinam, meropenem, metampicillin, meticillin, mezlocillin, moxalactam, nafcillin, northienamycin, oxacillin, panipenem, penamecillin, penicillin, phenethicillin, piperacillin, tazobactam, pivampicillin, pivcefalexin, pivmecillinam, pivmecillinam hydrochloride, pluracidomycin, propicillin, sarmoxicillin, sulbactam, sulbenicillin, talampicillin, temocillin, terconazole, thienamycin, and ticarcillin;

ii. an aminoglycoside, selected from the group consisting of 1,2′

-N-DL-isoseryl-3′

,4′

-dideoxykanamycin B, 1,2′

-N-DL-isoseryl-kanamycin B, 1,2′

-N[(S)-4-amino-2-hydroxybutyryl]-3′

,4′

-dideoxykanamycin B, 1,2′

-N-[(S) -4-amino-2-hydroxybutyryq-kanamycin B, 1-N-(2-Aminobutanesulfonyl) kanamycin A, 1-N-(2-aminoethanesulfonyl)3,4′

-dideoxyribostamycin, 1-N-(2-Aminoethanesulfonyl)3′

-deoxyribostamycin, 1-N-(2-aminoethanesulfonyl)3′

,4′

-dideoxykanamycin B, 1-N-(2-aminoethanesulfonyl)kanamycin A, 1-N-(2-aminoethanesulfonyl)kanamycin B, 1-N-(2-aminoethanesulfonyl)ribostamycin, 1-N-(2-aminopropanesulfonyl)3′

-deoxykanamycin B, 1-N-(2-aminopropanesulfonyl)3′

,4′

- dideoxykanamycin B, 1-N-(2-aminopropanesulfonyl)kanamycin A, 1-N -(2-aminopropanesulfonyl)kanamycin B, 1-N-(L-4-amino-2-hydroxy -butyryl)2,′

3′

-dideoxy-2′

-fluorokanamycin A, 1-N-(L-4-amino-2-hydroxy -propionyl)2,′

3′

-dideoxy-2′

-fluorokanamycin A, 1-N-DL-3′

,4′

-dideoxy -isoserylkanamycin B,1-N-DL-isoserylkanamycin, 1-N-DL -isoserylkanamycin B, 1-N[L-(-)-(alpha-hydroxy-gamma-aminobutyryl)]-XK-62-2, 2′

,3′

-dideoxy-2′

-fluorokanamycin A,2-hydroxygentamycin A3, 2-hydroxygentamycin B, 2-hydroxygentamycin B1, 2-hydroxygentamycin JI-20A, 2-hydroxygentamycin JI-20B, 3″

-N-methyl-4″

-C-methyl-3′

,4′

-dodeoxy kanamycin A, 3″

-N-methyl-4″

-C-methyl-3′

,4′

-dodeoxy kanamycin B, 3″

-N-methyl-4″

-C-methyl-3′

,4′

-dodeoxy-6′

-methyl kanamycin B, 3′

,4′

-Dideoxy-3′

-eno-ribostamycin,3′

,4′

-dideoxyneamine,3′

,4′

-dideoxyribostamycin, 3′

-deoxy-6′

-N-methyl -kanamycin B,3′

-deoxyneamine,3′

-deoxyribostamycin, 3′

-oxysaccharocin,3,3′

-nepotrehalosadiamine, 3-demethoxy-2″

-N -formimidoylistamycin B disulfate tetrahydrate, 3-demethoxyistamycin B,3-O-demethyl-2-N-formimidoylistamycin B, 3-O-demethylistamycin B,3-trehalosamine,4″

, 6″

-dideoxydibekacin, 4-N-glycyl-KA-6606VI, 5″

-Amino-3′

,4′

,5″

-trideoxy-butirosin A, 6″

-deoxydibekacin,6′

-epifortimicin A, 6-deoxy-neomycin (structure 6-deoxy-neomycin B),6-deoxy-neomycin B, 6-deoxy-neomycin C, 6-deoxy-paromomycin, acmimycin, AHB-3′

,4′

-dideoxyribostamycin,AHB-3′

-deoxykanamycin B, AHB-3′

-deoxyneamine,AHB-3′

-deoxyribostamycin,AHB-4″

-6″

-dideoxydibekacin, AHB-6″

-deoxydibekacin,AHB-dideoxyneamine,AHB-kanamycin B, AHB -methyl-3′

-deoxykanamycin B, amikacin, amikacin sulfate, apramycin, arbekacin, astromicin, astromicin sulfate, bekanamycin, bluensomycin, boholmycin, butirosin, butirosin B, catenulin, coumamidine gamma1, coumamidine gamma2,D,L-1-N-(alpha-hydroxy-beta-aminopropionyI) -XK-62-2, dactimicin,de-O-methyl-4-N-glycyl-KA-6606VI,de-O-methyl-KA -66061, de-O-methyl-KA-70381,destomycin A, destomycin B, di-N6′

,O3- demethylistamycin A, dibekacin, dibekacin sulfate, dihydrostreptomycin, dihydrostreptomycin sulfate, epi-formamidoylglycidylfortimicin B, epihygromycin, formimidoyl-istamycin A, formimidoyl-istamycin B, fortimicin B, fortimicin C, fortimicin D, fortimicin KE, fortimicin KF, fortimicin KG, fortimicin KG1 (stereoisomer KG1 /KG2), fortimicin KG2 (stereoisomer KG1 /KG2), fortimicin KG3, framycetin, framycetin sulphate, gentamicin, gentamycin sulfate, globeomycin, hybrimycin A1, hybrimycin A2, hybrimycin B1, hybrimycin B2, hybrimycin C1, hybrimycin C2, hydroxystreptomycin, hygromycin, hygromycin B, isepamicin, isepamicin sulfate, istamycin, kanamycin, kanamycin sulphate, kasugamycin, lividomycin, marcomycin, micronomicin, micronomicin sulfate, mutamicin, myomycin, N-demethyl-7-O-demethylcelesticetin, demethylcelesticetin, methanesulfonic acid derivative of istamycin, nebramycin, nebramycin, neomycin, netilmicin, oligostatin, paromomycin, quintomycin, ribostamycin, saccharocin, seldomycin, sisomicin, sorbistin, spectinomycin, streptomycin, tobramycin, trehalosmaine, trestatin, validamycin, verdamycin, xylostasin, and zygomycin;

iii. an ansa-type antibiotic, selected from the group consisting of 21-hydroxy-25-demethyl-25-methylthioprotostreptovaricin, 3-methylthiorifamycin, ansamitocin, atropisostreptovaricin, awamycin, halomicin, maytansine, naphthomycin, rifabutin, rifamide, rifampicin, rifamycin, rifapentine, rifaximin, rubradirin, streptovaricin, and tolypomycin;

iv. an anthraquinone, selected from the group consisting of auramycin, cinerubin, ditrisarubicin, ditrisarubicin C, figaroic acid fragilomycin, minomycin, rabelomycin, rudolfomycin, and sulfurmycin;

v. an azole, selected from the group consisting of azanidazole, bifonazole, butoconazol, chlormidazole, chlormidazole hydrochloride, cloconazole, cloconazole monohydrochloride, clotrimazol, dimetridazole, econazole, econazole nitrate, enilconazole, fenticonazole, fenticonazole nitrate, fezatione, fluconazole, flutrimazole, isoconazole, isoconazole nitrate, itraconazole, ketoconazole, lanoconazole, metronidazole, metronidazole benzoate, miconazole, miconazole nitrate, neticonazole, nimorazole, niridazole, omoconazol, ornidazole, oxiconazole, oxiconazole nitrate, propenidazole, secnidazol, sertaconazole, sertaconazole nitrate, sulconazole, sulconazole nitrate, tinidazole, tioconazole, and voriconazol;

vi. a glycopeptide, selected from the group consisting of acanthomycin, actaplanin, avoparcin, balhimycin, bleomycin B (copper bleomycin), chloroorienticin, chloropolysporin, demethylvancomycin, enduracidin, galacardin, guanidylfungin, hachimycin, demethylvancomycin, N-nonanoyl-teicoplanin, phleomycin, platomycin, ristocetin, staphylocidin, talisomycin, teicoplanin, vancomycin, victomycin, xylocandin, and zorbamycin;

vii. a macrolide, selected from the group consisting of acetylleucomycin, acetylkitasamycin, angolamycin, azithromycin, bafilomycin, brefeldin, carbomycin, chalcomycin, cirramycin, clarithromycin, concanamycin, deisovaleryl-niddamycin, demycinosyl -mycinamycin, Di-O-methyltiacumicidin, dirithromycin, erythromycin, erythromycin estolate, erythromycin ethyl succinate, erythromycin lactobionate, erythromycin stearate, flurithromycin, focusin, foromacidin, haterumalide, haterumalide, josamycin, josamycin ropionate, juvenimycin, juvenimycin, kitasamycin, ketotiacumicin, lankavacidin, lankavamycin, leucomycin, machecin, maridomycin, megalomicin, methylleucomycin, methymycin, midecamycin, miocamycin, mycaminosyltylactone, mycinomycin, neutramycin, niddamycin, nonactin, oleandomycin, phenylacetyldeltamycin, pamamycin, picromycin, rokitamycin, rosaramicin, roxithromycin, sedecamycin, shincomycin, spiramycin, swalpamycin, tacrolimus, telithromycin, tiacumicin, tilmicosin, treponemycin, troleandomycin, tylosin, and venturicidin;

viii. a nucleoside, selected from the group consisting of amicetin, angustmycin, azathymidine, blasticidin S, epiroprim, flucytosine, gougerotin, mildiomycin, nikkomycin, nucleocidin, oxanosine, oxanosine, puromycin, pyrazomycin, showdomycin, sinefungin, sparsogenin, spicamycin, tunicamycin, uracil polyoxin, and vengicide;

ix. a peptide, selected from the group consisting of actinomycin, aculeacin, alazopeptin, amfomycin, amythiamycin, antifungal from Zalerion arboricola, antrimycin, apid, apidaecin, aspartocin, auromomycin, bacileucin, bacillomycin, bacillopeptin, bacitracin, bagacidin, berninamycin, beta-alanyl-L-tyrosine, bottromycin, capreomycin, caspofungine, cepacidine, cerexin, cilofungin, circulin, colistin, cyclodepsipeptide, cytophagin, dactinomycin, daptomycin, decapeptide, desoxymulundocandin, echanomycin, echinocandin B, echinomycin, ecomycin, enniatin, etamycin, fabatin, ferrimycin, ferrimycin, ficellomycin, fluoronocathiacin, fusaricidin, gardimycin, gatavalin, globopeptin, glyphomycin, gramicidin, herbicolin, iomycin, iturin, iyomycin, izupeptin, janiemycin, janthinocin, jolipeptin, katanosin, killertoxin, lipopeptide antibiotic, lipopeptide from Zalerion sp., lysobactin, lysozyme, macromomycin, magainin, melittin, mersacidin, mikamycin, mureidomycin, mycoplanecin, mycosubtilin, neopeptifluorin, neoviridogrisein, netropsin, nisin, nocathiacin, nocathiacin 6 -deoxyglycoside, nosiheptide, octapeptin, pacidamycin, pentadecapeptide, peptifluorin, permetin, phytoactin, phytostreptin, planothiocin, plusbacin, polcillin, polymyxin antibiotic complex, polymyxin B, polymyxin B1, polymyxin F, preneocarzinostatin, quinomycin, quinupristin-dalfopristin, safracin, salmycin, salmycin, salmycin, sandramycin, saramycetin, siomycin, sperabillin, sporamycin, a streptomyces compound, subtilin, teicoplanin aglycone, telomycin, thermothiocin, thiopeptin, thiostrepton, tridecaptin, tsushimycin, tuberactinomycin, tuberactinomycin, tyrothricin, valinomycin, viomycin, virginiamycin, and zervacin;

x. a polyene, selected from the group consisting of amphotericin, amphotericin, aureofungin, ayfactin, azalomycin, blasticidin, candicidin, candicidin methyl ester, candimycin, candimycin methyl ester, chinopricin, filipin, flavofungin, fradicin, hamycin, hydropricin, levorin, lucensomycin, lucknomycin, mediocidin, mediocidin methyl ester, mepartricin, methylamphotericin, natamycin, niphimycin, nystatin, nystatin methyl ester, oxypricin, partricin, pentamycin, perimycin, pimaricin, primycin, proticin, rimocidin, sistomycosin, sorangicin, and trichomycin;

xi. a polyether, selected from the group consisting of 20-deoxy-epi -narasin, 20-deoxysalinomycin, carriomycin, dianemycin, dihydrolonomycin, etheromycin, ionomycin, iso-lasalocid, lasalocid, lenoremycin, lonomycin, lysocellin, monensin, narasin, oxolonomycin, a polycyclic ether antibiotic, and salinomycin;

xii. a quinolone, selected from the group consisting of alkyl -methylendioxy-4(1 H)-oxocinnoline-3-carboxylic acid, alatrofloxacin, cinoxacin, ciprofloxacin, ciprofloxacin hydrochloride, danofloxacin, dermofongin A, enoxacin, enrofloxacin, fleroxacin, flumequine, gatifloxacin, gemifloxacin, grepafloxacin, levofloxacin, lomefloxacin, lomefloxacin, hydrochloride, miloxacin, moxifloxacin, nadifloxacin, nalidixic acid, nifuroquine, norfloxacin, ofloxacin, orbifloxacin, oxolinic acid, pazufloxacine, pefloxacin, pefloxacin mesylate, pipemidic acid, piromidic acid, premafloxacin, rosoxacin, rufloxacin, sparfloxacin, temafloxacin, tosufloxacin, and trovafloxacin;

xiii. a steroid, selected from the group consisting of aminosterol, ascosteroside, cladosporide, dihydrofusidic acid, dehydro-dihydrofusidic acid, dehydrofusidic acid, fusidic acid, and squalamine;

xiv. a sulfonamide, selected from the group consisting of chloramine, dapsone, mafenide, phthalylsulfathiazole, succinylsulfathiazole, sulfabenzamide, sulfacetamide, sulfachlorpyridazine, sulfadiazine, sulfadiazine silver, sulfadicramide, sulfadimethoxine, sulfadoxine, sulfaguanidine, sulfalene, sulfamazone, sulfamerazine, sulfamethazine, sulfamethizole, sulfamethoxazole, sulfamethoxypyridazine, sulfamonomethoxine, sulfamoxol, sulfanilamide, sulfaperine, sulfaphenazol, sulfapyridine, sulfaquinoxaline, sulfasuccinamide, sulfathiazole, sulfathiourea, sulfatolamide, sulfatriazin, sulfisomidine, sulfisoxazole, sulfisoxazole acetyl, and sulfacarbamide;

xv. a tetracycline, selected from the group consisting of dihydrosteffimycin, demethyltetracycline, aclacinomycin, akrobomycin, baumycin, bromotetracycline, cetocyclin, chlortetracycline, clomocycline, daunorubicin, demeclocycline, doxorubicin, doxorubicin hydrochloride, doxycycline, lymecyclin, marcellomycin, meclocycline, meclocycline sulfosalicylate, methacycline, minocycline, minocycline hydrochloride, musettamycin, oxytetracycline, rhodirubin, rolitetracycline, rubomycin, serirubicin, steffimycin, and tetracycline;

xvi. a dicarboxylic acid, selected from the group consisting of adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1, 11-undecanedioic acid, 1,12-dodecanedioic acid, 1,13-tridecanedioic acid, and 1,14-tetradecanedioic acid;

xvii. an antibiotic metal or a metal ion, wherein the metal is selected from the group consisting of silver, copper, zinc, mercury, tin, lead, bismutin, cadmium, chromium, and gold;

xviii. a silver compound, selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver iodate, silver iodide, silver lactate, silver laurate, silver nitrate, silver oxide, silver palmitate, silver protein, and silver sulfadiazine;

xix. an oxidizing agent or a substance that releases free radicals and/or active oxygen, selected from the group consisting of oxygen, hydrogen peroxide, benzoyl peroxide, elemental halogen species, oxygenated halogen species, bleaching agents, perchlorite species, iodine, iodate, and benzoyl peroxide;

xx. a cationic antimicrobial agent, selected from the group consisting of quaternary ammonium compounds, alkyltrimethyl ammonium bromide, cetrimide, benzalkonium chloride, n-alkyldimethylbenzyl ammonium chloride, dialkylmethyl ammonium halide, and dialkylbenzyl ammonium halide;

xxi. a biguanide, a biguanidine or a triguanide having a skeleton selected from;

21. The method of claim 1, wherein the foamable composition further comprises at least one additional active agent.

22. The method of claim 21, wherein the additional active agent is selected from the group consisting of a steroidal anti-inflammatory agent, an immunosuppressive agent, an immunomodulator, an immunoregulating agent, a hormonal agent, an antifungal agent, an antiviral agent, an antiparasitic agent, vitamin A, a vitamin A derivative, vitamin B, a vitamin B derivative, vitamin C, a vitamin C derivative, vitamin D, a vitamin D derivative, vitamin E, a vitamin E derivative, vitamin F, a vitamin F derivative, vitamin K, a vitamin K derivative, a wound healing agent, a disinfectant, an anesthetic, an antiallergic agent, an alpha hydroxyl acid, lactic acid, glycolic acid, a beta-hydroxy acid, a protein, a peptide, a neuropeptide, a allergen, an immunogenic substance, a haptene, an oxidizing agent, an antioxidant, a dicarboxylic acid, azelaic acid, sebacic acid, adipic acid, fumaric acid, a retinoid, an antiproliferative agent, an anticancer agent, a photodynamic therapy agent, benzoyl chloride, calcium hypochlorite, magnesium hypochlorite, an anti-wrinkle agent, a radical scavenger, a metal, silver, a metal oxide, titanium dioxide, zinc oxide, zirconium oxide, iron oxide, silicone oxide, talc, carbon, an anti wrinkle agent, a skin whitening agent, a skin protective agent, a masking agent, an anti-wart agent, a refatting agent, a lubricating agent and mixtures thereof.

23. The method of claim 20, wherein the composition further contains a penetration enhancer.

24. The method of claim 23, wherein the penetration enhancer is selected from the group consisting of propylene glycol, butylene glycols, hexylene glycol, glycerol, pentaerythritol, sorbitol, mannitol, oligosaccharides, dimethyl isosorbide, monooleate of ethoxylated glycerides having about 8 to 10 ethylene oxide units, polyethylene glycol 200-600, transcutol, glycofurol, cyclodextrins, and mixtures of any two or more thereof.

25. The method of claim 1, wherein the pH of the foamable composition is selected from the group consiting of (i) between about 4.5 and about 7.0, wherein the composition is intended for skin treatment;

and (ii) between about 3 and about 4.5, wherein the composition is intended for vaginal treatment.

26. The method of claim 25, wherein pH of the composition is adjusted using an agent selected from the group consisting of an acid, a base and a buffering agent.

27. The method of claim 1, wherein the organic carrier contains a PPG alkyl ether.

28. The method of claim 27, wherein the concentration of the PPG alkyl ether is between about 1% and about 20%.

29. The method of claim 27, wherein the foam is non-flammable, when tested according to European Standard prEN 14851.

30. The method of claim 23, wherein the antibiotic agent is an antibiotic azole and wherein the penetration enhancer is selected from the group consisting of propylene glycol, hexylene glycol, glycerol, and dimethyl isosorbide.

31. The method of claim 24, wherein the antibiotic agent is an antibiotic azole and wherein the penetration enhancer is selected from the group consisting of propylene glycol, hexylene glycol, glycerol, polyethylene glycol, and dimethyl isosorbide.

32. The method of claim 31, wherein the antibiotic azole is metronidazole, and wherein the concentration of metronidazole is greater than 0.75%.

33. The method of claim 32, wherein the concentration of metronidazole is between about 0.9% and about 2%.

34. The method of claim 24, wherein the antibiotic agent is a dicarboxylic acid and wherein the penetration enhancer is selected from the group consisting of propylene glycol, hexylene glycol, glycerol, polyethylene glycol, and dimethyl isosorbide.

35. The method of claim 1, wherein the antibiotic agent is azelaic acid, and wherein the concentration of the azelaic acid is greater than 10%.

36. The method of claim 35, wherein the concentration of the azelaic acid is between about 10% and about 25%.

37. The method of claim 21, wherein the antibiotic agent is suitable for the treatment of impetigo and the additional active agent is an anti-inflammatory agent.

38. The method of claim 21, wherein the antibiotic agent is suitable for the treatment of chronic ulcer and the additional active agent is selected from the group consisting of a topical anesthetic agent, an antifungal, an anti viral infections agent, and a vasoactive agent.

39. The method of claim 21, wherein the antibiotic agent is suitable for the treatment of acne and the additional active agent is selected from the group consisting of a retinoid, a keratolytic acid, an alpha-hydroxy acid and derivatives thereof, a beta-hydroxy acid and derivatives thereof, a skin-drying agent, a corticosteroid, a non-steroidal anti-inflammatory agent, and an anti-seborrhea agent.

40. The method of claim 21, wherein the antibiotic agent is suitable for the treatment of rosacea and the additional active agent is selected from the group consisting of a retinoid, a keratolytic acid, an alpha-hydroxy acid, a beta-hydroxy acid, a corticosteroid, and a non-steroidal anti-inflammatory agent.

41. The method of claim 21, wherein the antibiotic agent is suitable for the treatment of otitis and the additional active agent is selected from the group consisting of an antifungal agent, a topical anesthetic agent, a corticosteroid, and a non-steroidal anti-inflammatory agent.

42. The method of claim 1, wherein the disorder is selected from the group consisting of a dermatose, a dermatitis, a vaginal disorder, a vulvar disorder, an anal disorder, a disorder of a body cavity, an ear disorder, a disorder of the nose, a disorder of the respiratory system, a bacterial infection, fungal infection, viral infection, dermatosis, dermatitis, parasitic infections, disorders of hair follicles and sebaceous glands, scaling papular diseases, benign tumors, malignant tumors, reactions to sunlight, bullous diseases, pigmentation disorders, disorders of cornification, pressure sores, disorders of sweating, inflammatory reactions, xerosis, ichthyosis, allergy, burn, wound, cut, chlamydia infection, gonorrhea infection, hepatitis B, herpes, HIV/AIDS, human papillomavirus (HPV), genital warts, bacterial vaginosis, candidiasis, chancroid, granuloma Inguinale, lymphogranloma venereum, mucopurulent cervicitis (MPC), molluscum contagiosum, nongonococcal urethritis (NGU), trichomoniasis, vulvar disorders, vulvodynia, vulvar pain, yeast infection, vulvar dystrophy, vulvar intraepithelial neoplasia (VIN), contact dermatitis, osteoarthritis, joint pain, hormonal disorder, pelvic inflammation, endometritis, salpingitis, oophoritis, genital cancer, cancer of the cervix, cancer of the vulva, cancer of the vagina, vaginal dryness, dyspareunia, anal and rectal disease, anal abscess/fistula, anal cancer, anal fissure, anal warts, Crohn'"'"'s disease, hemorrhoids, anal itch, pruritus ani, fecal incontinence, constipation, polyps of the colon and rectum;

and wherein the disorder is responsive to treatment with the antibiotic agent.

43. The method of claim 1, wherein the surface-active agent comprises a combination of at least one non-ionic surfactant having HLB of less than 9 and at least one non-ionic surfactant having HLB of equal or more than 9, wherein the ratio between the at least one non-ionic surfactant having HLB of less than 9 and the at least one non-ionic surfactant having HLB of equal or more than 9, is between 1:

4 and 4;

1.

44. The method of claim 34, wherein the resulting HLB value of the combination of at least one non-ionic surfactant having HLB of less than 9 and at least one non-ionic surfactant having HLB of equal or more than 9 is between about 9 and about 14.

45. The method of claim 1, wherein the surface-active agent consists of one or more non-ionic surfactants.

46. The method of claim 1, wherein the surface-active agent comprises a combination of at least one non-ionic surfactant having HLB of less than 9 and at least one non-ionic surfactant having HLB of equal or more than 9, wherein the ratio between the at least one non-ionic surfactant having HLB of less than 9 and the at least one non-ionic surfactant having HLB of equal or more than 9, is between 1:

8 and 8;

1.

47. The composition of claim 46, wherein the resulting HLB value of the combination of at least one non-ionic surfactant having HLB of less than 9 and at least one non-ionic surfactant having HLB of equal or more than 9 is between about 9 and about 14.

48. The method of claim 1, wherein the surface-active agent comprises a combination of a non-ionic surfactant and an ionic surfactant, at a ratio of between about 4:

1 and about 1;

4.

49. The method of claim 1, wherein the therapeutically active oil comprises about 20 to about 50% by weight of the composition of a capric/caprylic triglyceride.

50. The method of claim 1, wherein the therapeutically active oil comprises about 10 to about 20% by weight of the composition of a capric/caprylic triglyceride.

51. The method of claim 1, wherein the composition further comprises a hydrophobic organic carrier comprising a polypropylene glycol alkyl ether.

52. The method of claim 1, wherein the polymeric additive is selected from the group consisting of:

a locust bean gum, a gelatin agar, a xanthan gum, a quince seed extract, a tragacanth gum, a guar gum, a starch, a chemically modified starch, a cellulose ether, an alkyl cellulose polymer, a hydroxyalkyl cellulose polymer, a hydroxypropyl guar gum, a soluble starch, a chitosan, a polyvinylpyrrolidone, a polyvinyl alcohol, a polyacrylic acid polymer, a polymethacrylic acid polymer, a polyvinyl acetate polymer, a polyvinyl chloride polymer, a polyvinylidene chloride polymer, silicone dioxide, and mixtures of two or more thereof.

53. The method of claim 19, wherein the antibiotic agent comprises a ciclopiroxolamine.

54. The method of claim 34, wherein the surface-active agent is about 0.1% to about 5% by weight of the composition;

wherein the composition further comprises about 0.1% to about 5% by weight of the composition of a foam adjuvant; and

wherein the composition further comprises a penetration enhancer.

55. The method of claim 54, wherein the surface-active agent comprises glyceryl stearate, poly(oxyethylene) (20) sorbitan monooleate, PEG-40 stearate and mixtures of two or more thereof;

wherein the foam adjuvant comprises cetostearyl alcohol;

wherein the penetration enhancer comprises dimethyl isosorbide, propylene glycol and mixtures thereof; and

wherein the polymeric additive comprises a methylcellulose, a xanthan gum and mixtures thereof.

56. The method of claim 1, wherein the disorder is rosacea or acne or hypepigmentation.

57. The method of claim 34, wherein the disorder is rosacea or acne or hypepigmentation.

78. The method of claim 1, wherein the antibiotic agent is azelaic acid;

and

wherein the concentration of azelaic acid is greater than 10%.

79. The method of claim 78, wherein the concentration of azelaic acid is between about 10% and about 25%.

58. A method of treating or alleviating disorders of a skin, body cavity or mucosal surface, wherein the disorder involves inflammation as one of its etiological factors, the method comprising:

a. releasing a foamable composition from an aerosol container to form an expanded thermally stable foam that collapses upon application of mechanical force, said foamable composition comprising a propellant and a composition, said composition comprising;

(i) an antibiotic agent;

(ii) about 2% to about 50% by weight of the composition of at least one hydrophobic organic carrier comprising a polypropylene glycol alkyl ether;

(iii) a therapeutically active oil comprising about 10% to about 50% by weight of the composition of a capric/caprylic triglyceride

(iv) a surface-active agent;

(v) about 0.01% to about 5% by weight of the composition of a polymeric additive selected from a bioadhesive agent, a gelling agent, a film forming agent and a phase change agent; and

(vi) water,

b. administering the foam to a target area having a disorder of the skin, body cavity or mucosa; and

c. collapsing the foam by applying mechanical force, wherein the foam is absorbed onto the target area,

wherein the antibiotic agent is administered in a therapeutically effective amount;

wherein the foamed composition contains less than 5% by weight of the composition of short chain alcohols having up to 5 carbon atoms in their carbon chain skeleton and one hydroxyl group; and

wherein the foamed composition is a thermally stable breakable foam.

59. The method of claim 58, wherein the concentration of the surface active agent is between about 0.1% and about 5% by weight of the composition.

60. The method of claim 58, wherein the composition further comprises about 0.1% to about 5% by weight of the composition of a therapeutically active foam adjuvant is selected from the group consisting of fatty alcohols having 15 or more carbons in their carbon chain;

fatty acids having 16 or more carbons in their carbon chain;

fatty alcohols derived from beeswax and including a mixture of alcohols, a majority of which has at least 20 carbon atoms in their carbon chain;

fatty alcohols having at least one double bond;

fatty acids having at least one double bond;

branched fatty alcohols;

branched fatty acids;

fatty acids substituted with a hydroxyl group;

cetyl alcohol;

stearyl alcohol;

arachidyl alcohol;

behenyl alcohol;

1-triacontanol;

hexadecanoic acid;

stearic acid;

arachidic acid;

behenic acid;

octacosanoic acid;

12-hydroxy stearic acid; and

mixtures of any two or more thereof.

61. The method of claim 58 or 60, wherein the antibiotic agent is selected from the group consisting of beta-lactam antibiotics, aminoglycosides, ansa-type antibiotics, anthraquinones, antibiotic azoles, antibiotic glycopeptides, macrolides, antibiotic nucleosides, antibiotic peptides, antibiotic polyenes, antibiotic polyethers, quinolones, antibiotic steroids, sulfonamides, tetracycline, dicarboxylic acids, antibiotic metals, oxidizing agents, substances that release free radicals and/or active oxygen, cationic antimicrobial agents, quaternary ammonium compounds, biguanides, triguanides, bisbiguanides and analogs and polymers thereof, naturally occurring antibiotic compounds, and ciclopirox.

62. The method of claim 58, wherein the composition further comprises at least one additional active agent, selected from the group consisting of a steroidal anti-inflammatory agent, an immunosuppressive agent, an immunomodulator, an immunoregulating agent, a hormonal agent, an antifungal agent, an antiviral agent, an antiparasitic agent, vitamin A, a vitamin A derivative, vitamin B, a vitamin B derivative, vitamin C, a vitamin C derivative, vitamin D, a vitamin D derivative, vitamin E, a vitamin E derivative, vitamin F, a vitamin F derivative, vitamin K, a vitamin K derivative, a wound healing agent, a disinfectant, an anesthetic, an antiallergic agent, an alpha hydroxyl acid, lactic acid, glycolic acid, a beta-hydroxy acid, a protein, a peptide, a neuropeptide, an allergen, an immunogenic substance, a haptene, an oxidizing agent, an antioxidant, a dicarboxylic acid, azelaic acid, sebacic acid, adipic acid, fumaric acid, a retinoid, an antiproliferative agent, an anticancer agent, a photodynamic therapy agent, benzoyl chloride, calcium hypochlorite, magnesium hypochlorite, an anti-wrinkle agent, a radical scavenger, a metal, silver, a metal oxide, titanium dioxide, zinc oxide, zirconium oxide, iron oxide, silicone oxide, talc, carbon, an anti wrinkle agent, a skin whitening agent, a skin protective agent, a masking agent, an anti-wart agent, a refatting agent, a lubricating agent, and mixtures of any two or more thereof.

63. The method of claim 58, wherein the composition further contains a penetration enhancer.

64. The method of claim 63, wherein the penetration enhancer is selected from the group consisting of propylene glycol, butylene glycols, hexylene glycol, glycerol, pentaerythritol, sorbitol, mannitol, oligosaccharides, dimethyl isosorbide, monooleate of ethoxylated glycerides having about 8 to 10 ethylene oxide units, polyethylene glycol 200-600, transcutol, glycofurol and cyclodextrins.

65. The method of claim 58, wherein the pH of the foamable composition is selected from the group consisting of (i) between about 4.5 and about 7.0, wherein the composition is intended for skin treatment;

and (ii) between about 3 and about 4.5, wherein the composition is intended for vaginal treatment.

66. The method of claim 58, wherein the polymeric additive is selected from the group consisting of a water-soluble polymer, a water-insoluble polymer, a gelling agent, an inorganic gelling agent, a mucoadhesive macromolecule and a film forming polymer.

67. The method of claim 66, wherein the water-soluble polymer is selected from the group consisting of a methylcellulose, a hydroxypropyl cellulose, a hydroxypropyl methylcellulose, a hydroxyethyl cellulose, a methylhydroxyethylcellulose, a hydroxyethylcarboxymethylcellulose, a carboxymethylcellulose, an xanthan gum, a guar gum, a carrageenin gum, a locust bean gum a tragacanth gum and mixtures of any two or more thereof.

68. The method of claim 58, wherein the foamable composition contains at least one therapeutically active oil.

69. The method of claim 65, wherein pH of the composition is adjusted using an agent, selected from the group consisting of an acid, a base and a buffering agent.

70. The method of claim 60, wherein the concentration of the PPG alkyl ether is between about 1% and about 20% by weight of the composition.

71. The method of claim 70, wherein the foam is non-flammable, when tested according to European Standard prEN 14851.

72. The method of claim 58, wherein the foam is non-flammable, when tested according to European Standard prEN 14851.

73. The method of claim 63, wherein the antibiotic agent is an antibiotic azole and wherein the penetration enhancer is selected from the group consisting of propylene glycol, hexylene glycol, glycerol, and dimethyl isosorbide.

74. The method of claim 64, wherein the antibiotic agent is an antibiotic azole and wherein the penetration enhancer is selected from the group consisting of propylene glycol, hexylene glycol, glycerol, polyethylene glycol and dimethyl isosorbide.

75. The method of claim 74, wherein the antibiotic azole is metronidazole;

and

wherein the concentration of metronidazole is greater than 0.75%.

76. The method of claim 75, wherein the concentration of metronidazole is between 0.9% and about 2%.

77. The method of claim 64, wherein the antibiotic agent is a dicarboxylic acid and wherein the penetration enhancer is selected from the group consisting of propylene glycol, hexylene glycol, glycerol, polyethylene glycol, and dimethyl isosorbide.

80. The method of claim 62, wherein the antibiotic agent is suitable for the treatment of impetigo and the additional active agent is an anti-inflammatory agent.

81. The method of claim 62, wherein the antibiotic agent is suitable for the treatment of chronic ulcer and the additional active agent is selected from the group consisting of a topical anesthetic agent, an antifungal, an anti viral infections and a vasoactive agent.

82. The method of claim 62, wherein the antibiotic agent is suitable for the treatment of acne and the additional active agent is selected from the group consisting of a retinoid, a keratolytic acid, an alpha-hydroxy acid and derivatives thereof, a beta-hydroxy acid and derivatives thereof, a skin-drying agent, a corticosteroid, a non-steroidal anti-inflammatory agent, and an anti-seborrhea agent.

83. The method of claim 62, wherein the antibiotic agent is suitable for the treatment of rosacea and the additional active agent is selected from the group consisting of a retinoid, a keratolytic acid, an alpha-hydroxy acid, a beta-hydroxy acid, a corticosteroid, and a non-steroidal anti-inflammatory agent.

84. The method of claim 62, wherein the antibiotic agent is suitable for the treatment of otitis and the additional active agent is selected from the group consisting of an antifungal agent, a topical anesthetic agent, a corticosteroid and a non-steroidal anti-inflammatory agent.

85. The method of claim 58, wherein the surface-active agent comprises a combination of at least one non-ionic surfactant having HLB of less than 9 and at least one non-ionic surfactant having HLB of equal or more than 9, wherein the ratio between the at least one non-ionic surfactant having HLB of less than 9 and the at least one non-ionic surfactant having HLB of equal or more than 9, is between 1:

8 and 8;

1.

86. The method of claim 85, wherein the resulting HLB value of the combination of at least one non-ionic surfactant having HLB of less than 9 and at least one non-ionic surfactant having HLB of equal or more than 9 is between about 9 and about 14.

87. The method of claim 58, wherein the surface-active agent comprises a combination of a non-ionic surfactant and an ionic surfactant, at a ratio of between about 4:

1 and about 1;

4.

88. The method of claim 58, wherein the antibiotic agent is selected from the group consisting of:

i. a beta-lactam selected from the group consisting of 2-(3-alanyl)clavam, 2-hydroxymethylclavam, 8-epi-thienamycin, acetyl-thienamycin, amoxicillin, amoxicillin sodium, amoxicillin trihydrate, amoxicillin -potassium clavulanate combination, ampicillin, ampicillin sodium, ampicillin trihydrate, ampicillin-sulbactam, apalcillin, aspoxicillin, azidocillin, azlocillin, aztreonam, bacampicillin, biapenem, carbenicillin, carbenicillin disodium, carfecillin, carindacillin, carpetimycin, cefacetril, cefaclor, cefadroxil, cefalexin, cefaloridine, cefalotin, cefamandole, cefamandole, cefapirin, cefatrizine, cefatrizine propylene glycol, cefazedone, cefazolin, cefbuperazone, cefcapene, cefcapene pivoxil hydrochloride, cefdinir, cefditoren, cefditoren pivoxil, cefepime, cefetamet, cefetamet pivoxil, cefixime, cefmenoxime, cefmetazole, cefminox, cefminox, cefmolexin, cefodizime, cefonicid, cefoperazone, ceforanide, cefoselis, cefotaxime, cefotetan, cefotiam, cefoxitin, cefozopran, cefpiramide, cefpirome, cefpodoxime, cefpodoxime proxetil, cefprozil, cefquinome, cefradine, cefroxadine, cefsulodin, ceftazidime, cefteram, cefteram pivoxil, ceftezole, ceftibuten, ceftizoxime, ceftriaxone, cefuroxime, cefuroxime axetil, cephalosporin, cephamycin, chitinovorin, ciclacillin, clavulanic acid, clometocillin, cloxacillin, cycloserine, deoxy pluracidomycin, dicloxacillin, dihydro pluracidomycin, epicillin, epithienamycin, ertapenem, faropenem, flomoxef, flucloxacillin, hetacillin, imipenem, lenampicillin, loracarbef, mecillinam, meropenem, metampicillin, meticillin, mezlocillin, moxalactam, nafcillin, northienamycin, oxacillin, panipenem, penamecillin, penicillin, phenethicillin, piperacillin, tazobactam, pivampicillin, pivcefalexin, pivmecillinam, pivmecillinam hydrochloride, pluracidomycin, propicillin, sarmoxicillin, sulbactam, sulbenicillin, talampicillin, temocillin, terconazole, thienamycin, and ticarcillin;

ii. an aminoglycoside, selected from the group consisting of 1,2′

-N-DL -isoseryl-3′

,4′

-dideoxykanamycin B, 1,2′

-N-DL-isoseryl-kanamycin B, 1,2′

-N[(S)-4-amino-2-hydroxybutyryl]-3′

,4′

-dideoxykanamycin B, 1,2′

-N-[(S) -4-amino-2-hydroxybutyryq-kanamycin B, 1-N-(2-Aminobutanesulfonyl) kanamycin A, 1-N-(2-aminoethanesulfonyl)3,4′

-dideoxyribostamycin, 1-N-(2-Aminoethanesulfonyl)3′

-deoxyribostamycin, 1-N-(2-aminoethanesulfonyl)3′

,4′

-dideoxykanamycin B, 1-N-(2-aminoethanesulfonyl)kanamycin A, 1-N-(2-aminoethanesulfonyl)kanamycin B, 1-N-(2-aminoethanesulfonyl)ribostamycin, 1-N-(2-aminopropanesulfonyl)3′

-deoxykanamycin B, 1-N-(2-aminopropanesulfonyl)3′

,4′

-dideoxykanamycin B, 1-N-(2-aminopropanesulfonyl)kanamycin A, 1-N -(2-aminopropanesulfonyl)kanamycin B, 1-N-(L-4-amino-2-hydroxy -butyryl)2,′

3′

-dideoxy-2′

-fluorokanamycin A, 1-N-(L-4-amino-2-hydroxy -propionyl)2,′

3′

-dideoxy-2′

-fluorokanamycin A, 1-N-DL-3′

,4′

-dideoxy -isoserylkanamycin B,1-N-DL-isoserylkanamycin, 1-N-DL -isoserylkanamycin B, 1-N[L-(-)-(alpha-hydroxy-gamma-aminobutyryl)]-XK-62-2, 2′

,3′

-dideoxy-2′

-fluorokanamycin A,2-hydroxygentamycin A3, 2-hydroxygentamycin B, 2-hydroxygentamycin B1, 2-hydroxygentamycin JI-20A, 2-hydroxygentamycin JI-20B, 3″

-N-methyl-4″

-C-methyl-3′

,4′

-dodeoxy kanamycin A, 3″

-N-methyl-4″

-C-methyl-3′

,4′

-dodeoxy kanamycin B, 3″

-N-methyl-4″

-C-methyl-3′

,4′

-dodeoxy-6′

-methyl kanamycin B, 3 ′

,4′

-Dideoxy-3′

-eno-ribostamycin, 3′

,4′

-dideoxyneamine,3′

,4′

-dideoxyribostamycin, 3′

-deoxy-6′

-N-methyl -kanamycin B,3′

-deoxyneamine,3′

-deoxyribostamycin, 3′

-oxysaccharocin,3,3′

-nepotrehalosadiamine, 3-demethoxy-2″

-N -formimidoylistamycin B disulfate tetrahydrate, 3-demethoxyistamycin B,3-O-demethyl-2-N-formimidoylistamycin B, 3-O-demethylistamycin B,3-trehalosamine,4″

, 6″

-dideoxydibekacin, 4-N-glycyl-KA-6606VI, 5″

-Amino-3′

,4′

,5″

-trideoxy-butirosin A, 6″

-deoxydibekacin,6′

-epifortimicin A, 6-deoxy-neomycin (structure 6-deoxy-neomycin B),6-deoxy-neomycin B, 6-deoxy-neomycin C, 6-deoxy-paromomycin, acmimycin, AHB-3′

,4′

-dideoxyribostamycin,AHB-3′

-deoxykanamycin B, AHB-3′

-deoxyneamine,AHB-3′

-deoxyribostamycin,AHB-4″

-6″

-dideoxydibekacin, AHB-6″

-deoxydibekacin,AHB-dideoxyneamine,AHB-kanamycin B, AHB -methyl-3′

-deoxykanamycin B, amikacin, amikacin sulfate, apramycin, arbekacin, astromicin, astromicin sulfate, bekanamycin, bluensomycin, boholmycin, butirosin, butirosin B, catenulin, coumamidine gamma1, coumamidine gamma2,D,L-1-N-(alpha-hydroxy-beta-aminopropionyl) -XK-62-2, dactimicin,de-O-methyl-4-N-glycyl-KA-6606VI,de-O-methyl-KA -66061, de-O-methyl-KA-70381,destomycin A, destomycin B, di-N6′

,O3-demethylistamycin A, dibekacin, dibekacin sulfate, dihydrostreptomycin, dihydrostreptomycin sulfate, epi-formamidoylglycidylfortimicin B, epihygromycin, formimidoyl-istamycin A, formimidoyl-istamycin B, fortimicin B, fortimicin C, fortimicin D, fortimicin KE, fortimicin KF, fortimicin KG, fortimicin KG1 (stereoisomer KG1 /KG2), fortimicin KG2(stereoisomer KG1 /KG2), fortimicin KG3, framycetin, framycetin sulphate, gentamicin, gentamycin sulfate, globeomycin, hybrimycin A1, hybrimycin A2, hybrimycin B1, hybrimycin B2, hybrimycin C1, hybrimycin C2, hydroxystreptomycin, hygromycin, hygromycin B, isepamicin, isepamicin sulfate, istamycin, kanamycin, kanamycin sulphate, kasugamycin, lividomycin, marcomycin, micronomicin, micronomicin sulfate, mutamicin, myomycin, N-demethyl-7-O-demethylcelesticetin, demethylcelesticetin, methanesulfonic acid derivative of istamycin, nebramycin, nebramycin, neomycin, netilmicin, oligostatin, paromomycin, quintomycin, ribostamycin, saccharocin, seldomycin, sisomicin, sorbistin, spectinomycin, streptomycin, tobramycin, trehalosmaine, trestatin, validamycin, verdamycin, xylostasin, and zygomycin;

iii. an ansa-type antibiotic selected from the group consisting of 21-hydroxy-25-demethyl-25-methylthioprotostreptovaricin, 3-methylthiorifamycin, ansamitocin, atropisostreptovaricin, awamycin, halomicin, maytansine, naphthomycin, rifabutin, rifamide, rifampicin, rifamycin, rifapentine, rifaximin, rubradirin, streptovaricin, and tolypomycin;

iv. an anthraquinone selected from the group consisting of auramycin, cinerubin, ditrisarubicin, ditrisarubicin C, figaroic acid fragilomycin, minomycin, rabelomycin, rudolfomycin, and sulfurmycin;

v. an azole selected from the group consisting of azanidazole, bifonazole, butoconazol, chlormidazole, chlormidazole hydrochloride, cloconazole, cloconazole monohydrochloride, clotrimazol, dimetridazole, econazole, econazole nitrate, enilconazole, fenticonazole, fenticonazole nitrate, fezatione, fluconazole, flutrimazole, isoconazole, isoconazole nitrate, itraconazole, ketoconazole, lanoconazole, metronidazole, metronidazole benzoate, miconazole, miconazole nitrate, neticonazole, nimorazole, niridazole, omoconazol, ornidazole, oxiconazole, oxiconazole nitrate, propenidazole, secnidazol, sertaconazole, sertaconazole nitrate, sulconazole, sulconazole nitrate, tinidazole, tioconazole, and voriconazol;

vi. a glycopeptide selected from the group consisting of acanthomycin, actaplanin, avoparcin, balhimycin, bleomycin B (copper bleomycin), chloroorienticin, chloropolysporin, demethylvancomycin, enduracidin, galacardin, guanidylfungin, hachimycin, demethylvancomycin, N -nonanoyl-teicoplanin, phleomycin, platomycin, ristocetin, staphylocidin, talisomycin, teicoplanin, vancomycin, victomycin, xylocandin, and zorbamycin;

vii. a macrolide selected from the group consisting of acetylleucomycin, acetylkitasamycin, angolamycin, azithromycin, bafilomycin, brefeldin, carbomycin, chalcomycin, cirramycin, clarithromycin, concanamycin, deisovaleryl-niddamycin, demycinosyl-mycinamycin, Di-O -methyltiacumicidin, dirithromycin, erythromycin, erythromycin estolate, erythromycin ethyl succinate, erythromycin lactobionate, erythromycin stearate, flurithromycin, focusin, foromacidin, haterumalide, haterumalide, josamycin, josamycin ropionate, juvenimycin, juvenimycin, kitasamycin, ketotiacumicin, lankavacidin, lankavamycin, leucomycin, machecin, maridomycin, megalomicin, methylleucomycin, methymycin, midecamycin, miocamycin, mycaminosyltylactone, mycinomycin, neutramycin, niddamycin, nonactin, oleandomycin, phenylacetyldeltamycin, pamamycin, picromycin, rokitamycin, rosaramicin, roxithromycin, sedecamycin, shincomycin, spiramycin, swalpamycin, tacrolimus, telithromycin, tiacumicin, tilmicosin, treponemycin, troleandomycin, tylosin, and venturicidin;

viii. a nucleoside selected from the group consisting of amicetin, angustmycin, azathymidine, blasticidin S, epiroprim, flucytosine, gougerotin, mildiomycin, nikkomycin, nucleocidin, oxanosine, oxanosine, puromycin, pyrazomycin, showdomycin, sinefungin, sparsogenin, spicamycin, tunicamycin, uracil polyoxin, and vengicide;

ix. a peptide selected from the group consisting of actinomycin, aculeacin, alazopeptin, amfomycin, amythiamycin, antifungal from Zalerion arboricola, antrimycin, apid, apidaecin, aspartocin, auromomycin, bacileucin, bacillomycin, bacillopeptin, bacitracin, bagacidin, berninamycin, beta-alanyl-L-tyrosine, bottromycin, capreomycin, caspofungine, cepacidine, cerexin, cilofungin, circulin, colistin, cyclodepsipeptide, cytophagin, dactinomycin, daptomycin, decapeptide, desoxymulundocandin, echanomycin, echinocandin B, echinomycin, ecomycin, enniatin, etamycin, fabatin, ferrimycin, ferrimycin, ficellomycin, fluoronocathiacin, fusaricidin, gardimycin, gatavalin, globopeptin, glyphomycin, gramicidin, herbicolin, iomycin, iturin, iyomycin, izupeptin, janiemycin, janthinocin, jolipeptin, katanosin, killertoxin, lipopeptide antibiotic, lipopeptide from Zalerion sp., lysobactin, lysozyme, macromomycin, magainin, melittin, mersacidin, mikamycin, mureidomycin, mycoplanecin, mycosubtilin, neopeptifluorin, neoviridogrisein, netropsin, nisin, nocathiacin, nocathiacin 6-deoxyglycoside, nosiheptide, octapeptin, pacidamycin, pentadecapeptide, peptifluorin, permetin, phytoactin, phytostreptin, planothiocin, plusbacin, polcillin, polymyxin antibiotic complex, polymyxin B, polymyxin B1, polymyxin F, preneocarzinostatin, quinomycin, quinupristin-dalfopristin, safracin, salmycin, salmycin, salmycin, sandramycin, saramycetin, siomycin, sperabillin, sporamycin, a streptomyces compound, subtilin, teicoplanin aglycone, telomycin, thermothiocin, thiopeptin, thiostrepton, tridecaptin, tsushimycin, tuberactinomycin, tuberactinomycin, tyrothricin, valinomycin, viomycin, virginiamycin, and zervacin;

x. a polyene selected from the group consisting of amphotericin, amphotericin, aureofungin, ayfactin, azalomycin, blasticidin, candicidin, candicidin methyl ester, candimycin, candimycin methyl ester, chinopricin, filipin, flavofungin, fradicin, hamycin, hydropricin, levorin, lucensomycin, lucknomycin, mediocidin, mediocidin methyl ester, mepartricin, methylamphotericin, natamycin, niphimycin, nystatin, nystatin methyl ester, oxypricin, partricin, pentamycin, perimycin, pimaricin, primycin, proticin, rimocidin, sistomycosin, sorangicin, and trichomycin;

xi. a polyether selected from the group consisting of 20-deoxy -epi-narasin, 20-deoxysalinomycin, carriomycin, dianemycin, dihydrolonomycin, etheromycin, ionomycin, iso-lasalocid, lasalocid, lenoremycin, lonomycin, lysocellin, monensin, narasin, oxolonomycin, a polycyclic ether antibiotic, and salinomycin;

xii. a quinolone selected from the group consisting of alkyl -methylendioxy-4(1 H)-oxocinnoline-3-carboxylic acid, alatrofloxacin, cinoxacin, ciprofloxacin, ciprofloxacin hydrochloride, danofloxacin, dermofongin A, enoxacin, enrofloxacin, fleroxacin, flumequine, gatifloxacin, gemifloxacin, grepafloxacin, levofloxacin, lomefloxacin, lomefloxacin, hydrochloride, miloxacin, moxifloxacin, nadifloxacin, nalidixic acid, nifuroquine, norfloxacin, ofloxacin, orbifloxacin, oxolinic acid, pazufloxacine, pefloxacin, pefloxacin mesylate, pipemidic acid, piromidic acid, premafloxacin, rosoxacin, rufloxacin, sparfloxacin, temafloxacin, tosufloxacin, and trovafloxacin;

xiii. a steroid selected from the group consisting of aminosterol, ascosteroside, cladosporide, dihydrofusidic acid, dehydro-dihydrofusidic acid, dehydrofusidic acid, fusidic acid, and squalamine;

xiv. a sulfonamide selected from the group consisting of chloramine, dapsone, mafenide, phthalylsulfathiazole, succinylsulfathiazole, sulfabenzamide, sulfacetamide, sulfachlorpyridazine, sulfadiazine, sulfadiazine silver, sulfadicramide, sulfadimethoxine, sulfadoxine, sulfaguanidine, sulfalene, sulfamazone, sulfamerazine, sulfamethazine, sulfamethizole, sulfamethoxazole, sulfamethoxypyridazine, sulfamonomethoxine, sulfamoxol, sulfanilamide, sulfaperine, sulfaphenazol, sulfapyridine, sulfaquinoxaline, sulfasuccinamide, sulfathiazole, sulfathiourea, sulfatolamide, sulfatriazin, sulfisomidine, sulfisoxazole, sulfisoxazole acetyl, and sulfacarbamide;

xv. a tetracycline selected from the group consisting of dihydrosteffimycin, demethyltetracycline, aclacinomycin, akrobomycin, baumycin, bromotetracycline, cetocyclin, chlortetracycline, clomocycline, daunorubicin, demeclocycline, doxorubicin, doxorubicin hydrochloride, doxycycline, lymecyclin, marcellomycin, meclocycline, meclocycline sulfosalicylate, methacycline, minocycline, minocycline hydrochloride, musettamycin, oxytetracycline, rhodirubin, rolitetracycline, rubomycin, serirubicin, steffimycin, and tetracycline;

xvi. a dicarboxylic acid selected from the group consisting of adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,11-undecanedioic acid, 1,12-dodecanedioic acid, 1,13-tridecanedioic acid, and 1,14-tetradecanedioic acid;

xvii. an antibiotic metal or a metal ion, wherein the metal is selected from the group consisting of silver, copper, zinc, mercury, tin, lead, bismutin, cadmium, chromium, and gold;

xviii. a silver compound selected from the group consisting of silver acetate, silver benzoate, silver carbonate, silver iodate, silver iodide, silver lactate, silver laurate, silver nitrate, silver oxide, silver palmitate, silver protein, and silver sulfadiazine;

xix. an oxidizing agent or a substance that releases free radicals or active oxygen, selected from the group consisting of oxygen, hydrogen peroxide, benzoyl peroxide, elemental halogen species, oxygenated halogen species, bleaching agents, perchlorite species, iodine, iodate, and benzoyl peroxide;

xx. a cationic antimicrobial agent selected from the group consisting of quaternary ammonium compounds, alkyltrimethyl ammonium bromide, cetrimide, benzalkonium chloride, n-alkyldimethylbenzyl ammonium chloride, dialkylmethyl ammonium halide, and dialkylbenzyl ammonium halide;

xxi. a biguanide a biguanidine or a triguanide having a skeleton selected from;

89. The method of claim 88, wherein the composition further comprises about 0.1% to about 0.5% by weight of the composition of a therapeutically active foam adjuvant selected from the group consisting of fatty alcohols having 15 or more carbons in their carbon chain;

fatty acids having 16 or more carbons in their carbon chain;

fatty alcohols derived from beeswax and including a mixture of alcohols, a majority of which has at least 20 carbon atoms in their carbon chain;

fatty alcohols having at least one double bond;

fatty acids having at least one double bond;

branched fatty alcohols;

branched fatty acids;

fatty acids substituted with a hydroxyl group;

cetyl alcohol;

stearyl alcohol;

arachidyl alcohol;

behenyl alcohol;

1-triacontanol;

hexadecanoic acid;

stearic acid;

arachidic acid;

behenic acid;

octacosanoic acid;

12-hydroxy stearic acid; and

mixtures of any two or more thereof.

90. The method of claim 58, wherein the antibiotic agent comprises a ciclopiroxolamine.

91. The method of claim 58, wherein the at least one organic carrier is present in an amount selected from the group consisting of (i) about 2% to about 5% by weight of the composition;

(ii) about 5% to about 10% by weight of the composition;

(iii) about 10% to about 20% by weight of the composition; and

(iv) about 20% to about 50% by weight of the composition.

92. A method of treating or alleviating disorders of a skin, body cavity or mucosal surface, wherein the disorder involves inflammation as one of its etiological factors, the method comprising:

a. releasing a foamable composition from an aerosol container to form an expanded thermally stable foam that collapses upon application of mechanical force, said foamable composition comprising a propellant and a composition, said composition comprising;

(i) an antibiotic agent;

(ii) at least one organic carrier selected from a hydrophobic organic carrier, a polar solvent, an emollient, or mixtures thereof, at a concentration of about 2% to about 50% by weight of the composition;

(iii) a therapeutically active oil comprising about 10% to about 50% by weight of the composition of a capric/caprylic triglyceride;

(iv) a surface-active agent;

(v) about 0.01% to about 5% by weight of the composition of a polymeric additive selected from the group consisting of;

a locust bean gum, a gelatin agar, a xanthan gum, a quince seed extract, a tragacanth gum, a guar gum, a starch, a chemically modified starch, a cellulose ether, an alkyl cellulose polymer, a hydroxyalkyl cellulose polymer, a hydroxypropyl guar gum, a soluble starch, a chitosan, a polyvinylpyrrolidone, a polyvinyl alcohol, a polyacrylic acid polymer, a polymethacrylic acid polymer, a polyvinyl acetate polymer, a polyvinyl chloride polymer, a polyvinylidene chloride polymer, silicone dioxide, and mixtures of two or more thereof; and

(vi) water,

b. administering the foam to a target area having a disorder of the skin, body cavity or mucosa; and

c. collapsing the foam by applying mechanical force, wherein the foam is absorbed onto the target area,

wherein the antibiotic agent is administered in a therapeutically effective amount;

wherein the foamed composition contains less than 5% by weight of the composition of short chain alcohols having up to 5 carbon atoms in their carbon chain skeleton and one hydroxyl group; and

wherein the foamed composition is a thermally stable breakable foam.

93. The method of claim 92, wherein the antibiotic agent comprises a ciclopiroxolamine.

94. The method of claim 92, wherein the surface-active agent is about 0.1% to about 5% by weight of the composition;

wherein the composition further comprises about 0.1% to about 5% by weight of the composition of a foam adjuvant; and

wherein the composition further comprises a penetration enhancer.

95. The method of claim 94, wherein the surface-active agent comprises glyceryl stearate, poly(oxyethylene) (20) sorbitan monooleate, PEG-40 stearate and mixtures of two or more thereof;

wherein the foam adjuvant comprises cetostearyl alcohol;

wherein the penetration enhancer comprises dimethyl isosorbide, propylene glycol and mixtures thereof; and

wherein the polymeric additive comprises a methylcellulose, a xanthan gum and mixtures thereof.

96. The method of claim 92, wherein the disorder is rosacea or acne or hypepigmentation.

97. The method of claim 95, wherein the disorder is rosacea or acne or hypepigmentation.