4′-fluoro nucleosides for the treatment of HCV
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Abstract
Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are according to Formula 1501:
or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, PD, RA, RB, RC, L, M and Z are as described herein.
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Citations
23 Claims
- 1. A compound according to Formula 1501:
- 19. A method for the treatment of a host infected with a hepatitis C virus comprising administering an effective amount of a compound according to Formula 1501:
- 22. A compound according to Formula 1501:
Specification