Systems and methods for limb treatment
First Claim
1. A method of delivering a medicament to a limb of a patient body, the method comprising:
- isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system comprises substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb;
inserting a perfusion catheter into a limb artery of the limb circulatory system in an antegrade position;
inserting a collection catheter into a limb vein of the limb circulatory system in a retrograde position, wherein an expandable non-occlusive support structure is at least partially disposed in the collection catheter during insertion, and wherein the perfusion catheter and the collection catheter each comprise an occlusion member constructed so as to move along a respective catheter;
extending the expandable non-occlusive support structure from the collection catheter so as to expand the expandable non-occlusive support structure within the limb vein;
circulating substantially all of a blood flow of the limb circulatory system by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter; and
perfusing a medicament to the limb circulatory system with the perfusion catheter.
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Abstract
A method of delivering a medicament to a limb of a patient body includes isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system is substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb. A perfusion catheter is inserted into a limb artery in an antegrade position, while a collection catheter is inserted into a limb vein in a retrograde position. The blood flow of the limb circulatory system is then circulated by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter. A medicament is perfused into the limb circulatory system with the perfusion catheter.
112 Citations
10 Claims
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1. A method of delivering a medicament to a limb of a patient body, the method comprising:
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isolating a circulatory system of the limb from a circulatory system of the patient body, wherein the limb circulatory system comprises substantially all limb arteries and substantially all limb veins located between an isolation region and an end of the limb; inserting a perfusion catheter into a limb artery of the limb circulatory system in an antegrade position; inserting a collection catheter into a limb vein of the limb circulatory system in a retrograde position, wherein an expandable non-occlusive support structure is at least partially disposed in the collection catheter during insertion, and wherein the perfusion catheter and the collection catheter each comprise an occlusion member constructed so as to move along a respective catheter; extending the expandable non-occlusive support structure from the collection catheter so as to expand the expandable non-occlusive support structure within the limb vein; circulating substantially all of a blood flow of the limb circulatory system by collecting the blood flow with the collection catheter and delivering the blood flow with the perfusion catheter; and perfusing a medicament to the limb circulatory system with the perfusion catheter. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification