Methods and systems for reducing inflammation by neuromodulation of T-cell activity
First Claim
1. A method of treating an inflammatory response, the method comprising:
- stimulating a subject'"'"'s inflammatory reflex to inhibit the immune response by stimulating the subject'"'"'s vagus nerve, wherein the stimulation is selected from the group consisting of electrical stimulation of the vagus nerve and mechanical stimulation of the vagus nerve, wherein the step of stimulating the subject'"'"'s inflammatory reflex is repeated at regular intervals of at least about 4 hours; and
administering an AChE inhibitor.
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Accused Products
Abstract
Described herein are devices, systems and method of treating inflammation, including methods of treating a T-cell mediated disease. In particular, described herein are methods of treating inflammation including the steps of stimulating a subject'"'"'s inflammatory reflex to inhibit the immune response and administering a T-cell modifying agent to modify the activity of splenic T-cells. Also described herein are systems for treating inflammation including an inflammatory reflex stimulation module and a T-cell response modifying module. The T-cell response modifying module typically modifies the response of splenic T-cells to enhance or otherwise regulate the effect of stimulation of the inflammatory reflex.
537 Citations
9 Claims
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1. A method of treating an inflammatory response, the method comprising:
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stimulating a subject'"'"'s inflammatory reflex to inhibit the immune response by stimulating the subject'"'"'s vagus nerve, wherein the stimulation is selected from the group consisting of electrical stimulation of the vagus nerve and mechanical stimulation of the vagus nerve, wherein the step of stimulating the subject'"'"'s inflammatory reflex is repeated at regular intervals of at least about 4 hours; and administering an AChE inhibitor. - View Dependent Claims (2, 3, 4, 5)
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6. A method of treating an inflammatory response, the method comprising:
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stimulating a subject'"'"'s inflammatory reflex to inhibit the immune response by stimulating the subject'"'"'s vagus nerve, wherein the stimulation is selected from the group consisting of electrical stimulation of the vagus nerve and mechanical stimulation of the vagus nerve, wherein the step of stimulating the subject'"'"'s inflammatory reflex is repeated at regular intervals of at least about 4 hours; and administering a glucocorticoid.
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7. A method of treating an inflammatory response, the method comprising:
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stimulating a subject'"'"'s inflammatory reflex to inhibit the immune response by stimulating the subject'"'"'s vagus nerve, wherein the stimulation is selected from the group consisting of electrical stimulation of the vagus nerve and mechanical stimulation of the vagus nerve, wherein the step of stimulating the subject'"'"'s inflammatory reflex is repeated at regular intervals of at least about 4 hours; and administering an immunosuppressive agent.
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8. A method of treating an inflammatory response, the method comprising:
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mechanically stimulating a subject'"'"'s inflammatory reflex to inhibit the immune response by stimulating the subject'"'"'s vagus nerve, wherein the step of stimulating the subject'"'"'s inflammatory reflex is repeated at regular intervals of at least about 4 hours; and administering an AChE inhibitor.
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9. A method of treating an inflammatory response, the method comprising:
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stimulating a subject'"'"'s inflammatory reflex to inhibit the immune response by stimulating the subject'"'"'s vagus nerve, wherein the stimulation is selected from the group consisting of electrical stimulation of the vagus nerve and mechanical stimulation of the vagus nerve; and administering an AChE inhibitor, wherein the step of administering the AChE inhibitor comprises local administration of the AChE inhibitor to the splenic region.
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Specification