Closed loop neural stimulation synchronized to cardiac cycles

• US 9,211,412 B2
• Filed: 03/13/2013
• Issued: 12/15/2015
• Est. Priority Date: 04/05/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: McCabe, Aaron R., Libbus, Imad, Zhang, Yi, Haefner, Paul A., Sathaye, Alok S., Caparso, Anthony V., Brooke, M. Jason
• Primary Examiner(s): MALAMUD, DEBORAH LESLIE
• Application Number:
  US13/798,684
• Publication Number:
  US 20130197594A1
• Time in Patent Office: 1,007 Days
• Field of Search: 607 1- 2, 607 4- 7, 607/9, 607/11, 607 14- 15, 607 27- 28, 607/115, 607/116, 607/119
• US Class Current: 1/1
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/36128 Control systems
• CPC Class Codes: A61N 1/36139 with automatic adjustment

Abstract

Various aspects of the present subject matter relate to a method. According to various method embodiments, cardiac activity is detected, and neural stimulation is synchronized with a reference event in the detected cardiac activity. Neural stimulation is titrated based on a detected response to the neural stimulation. Other aspects and embodiments are provided herein.

Claims

1. A method for treating a patient, comprising:

detecting an electric pulse generated by a cardiac rhythm management (CRM) device; and

activating a baroreflex therapy in response to the detected electric pulse, or if the baroreflex therapy is currently activated increasing an intensity of the baroreflex activation therapy upon detection of the electric pulse.

2. The method of claim 1, wherein the CRM device comprises a pacemaker, a cardiac resynchronization therapy (CRT) device, or a cardioverter.

3. The method of claim 1, further comprising discontinuing the activation of the baroreflex system of the patient after expiration of a pre-selected period of time.

4. The method of claim 1, wherein the baroreflex therapy is activated in response to the detected electric pulse.

5. The method of claim 4, wherein the CRM device comprises a defibrillator.

6. The method of claim 4, further comprising discontinuing the activation of the baroreflex system of the patient after expiration of a pre-selected period of time.

7. The method of claim 4, wherein the baroreflex system of the patient is activated after expiration of a pre-selected period of time.

8. The method of claim 7, wherein the CRM device comprises a pacemaker.

9. The method of claim 7, wherein the CRM device comprises a cardiac resynchronization therapy (CRT) device.

10. The method of claim 7, wherein the CRM device comprises a cardioverter.

11. The method of claim 7, wherein detecting the electric pulse generated by the CRM device comprises measuring a voltage difference between a BAT electrode and a housing of a BAT device.

12. The method of claim 7, wherein detecting the electric pulse generated by the CRM device comprises measuring a voltage difference between a lead of the CRM device and a housing of a BAT device.

13. The method of claim 7, wherein detecting the electric pulse generated by the CRM device comprises measuring a voltage difference between a lead of the CRM device and an electrode of a BAT device.

14. The method of claim 1, wherein the method includes:

delivering baroreflex activation therapy to a body of the patient and increasing an intensity of the baroreflex activation therapy upon detection of the electrical pulse.

15. The method of claim 14, wherein the CRM device comprises an implantable defibrillator.

16. The method of claim 14, further comprising returning the baroreflex activation therapy to an original intensity after expiration of a pre-selected period of time.

17. The method of claim 1, wherein the method includes delivering baroreflex activation therapy to a body of the patient at a first intensity and delivering baroreflex activation therapy to the body of the patient at a second intensity after the electrical pulse has been detected.

18. The method of claim 17, wherein the second intensity is greater than the first intensity.

19. The method of claim 17, wherein the CRM device comprises an implantable defibrillator.

20. The method of claim 17, further comprising delivering baroreflex activation therapy to the body of the patient at the first intensity after expiration of a pre-selected period of time.