Porous inorganic/organic homogenous copolymeric hybrid materials for chromatographic separations and process for the preparation thereof

• US 9,211,524 B2
• Filed: 03/12/2014
• Issued: 12/15/2015
• Est. Priority Date: 10/30/2002
• Status: Active Grant

• Current Assignee: Waters Technologies Corporation (Waters Corporation)
• Original Assignee: Waters Technologies Corporation (Waters Corporation)
• Inventors: Jiang, Zhiping, O'Gara, John E., Fisk, Raymond P., Wyndham, Kevin D., Brousmiche, Darryl W.
• Primary Examiner(s): MOORE, MARGARET G
• Application Number:
  US14/206,538
• Publication Number:
  US 20140194283A1
• Time in Patent Office: 643 Days
• US Class Current: 1/1
• CPC Class Codes: B01J 20/26 Synthetic macromolecular compounds
• CPC Class Codes: B01J 20/265 modified or post-treated polymers polymer carriers or substrates subjected to further impregnating or coating B01J20/3208
• CPC Class Codes: B01J 20/28019 Spherical, ellipsoidal or cylindrical
• CPC Class Codes: B01J 20/28042 Shaped bodies; Monolithic structures
• CPC Class Codes: B01J 20/285 based on polymers
• CPC Class Codes: B01J 20/286 Phases chemically bonded to a substrate, e.g. to silica or to polymers
• CPC Class Codes: B01J 2220/82 Shaped bodies, e.g. monoliths, plugs, tubes, continuous beds
• CPC Class Codes: C08F 230/085 the monomer being a polymerisable silane, e.g. (meth)acryloyloxy trialkoxy silanes or vinyl trialkoxysilanes
• CPC Class Codes: C08G 77/442 containing vinyl polymer sequences
• CPC Class Codes: C08J 2329/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C08J 2383/06 containing silicon bound to oxygen-containing groups C08J2383/12 takes precedence
• CPC Class Codes: C08J 9/35 Composite foams, i.e. continuous macromolecular foams containing discontinuous cellular particles or fragments
• CPC Class Codes: C08L 2666/02 Organic macromolecular compounds, natural resins, waxes or and bituminous materials
• CPC Class Codes: C08L 53/00 Compositions of block copolymers containing at least one sequence of a polymer obtained by reactions only involving carbon-to-carbon unsaturated bonds; Compositions of derivatives of such polymers
• CPC Class Codes: C08L 53/005 Modified block copolymers
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]

Abstract

The present invention relates to porous inorganic/organic homogenous copolymeric hybrid material materials, including particulates and monoliths, methods for their manufacture, and uses thereof, e.g., as chromatographic separations materials.

Claims

1. A porous inorganic/organic homogenous copolymeric hybrid material of the formula:

(A)_x(B)_y(C)_z

wherein the order of repeat units A, B, and C may be random, block, or a combination of random and block;

A is selected from the group consisting of

3. The material according to claim 1, wherein 0.003≦

y/z≦

50 and 0.02≦

x/(y+z)≦

21.

4. The material according to claim 1, wherein said material has a specific surface area of about 50-800 m²/g.

5. The material according to claim 1, wherein said material is hydrolytically stable at a pH of about 1 to about 13.

9. A separations device comprising a material according to claim 1.

10. The separations device according to claim 9, wherein said device is selected from the group consisting of chromatographic columns, thin layer plates, filtration membranes, sample cleanup devices, and microtiter plates.

13. The porous inorganic/organic homogenous copolymeric hybrid material of claim 1, wherein z=0 and the hybrid material is of the formula:

(A)_x(B)_y

wherein the order of repeat units A and B may be random, block, or a combination of random and block;

A is selected from the group consisting of

2. A porous inorganic/organic homogenous copolymeric hybrid material of the formula:

(A)_x(B)_y(B*)_y*(C)_z

wherein the order of repeat units A, B, B*, and C may be random, block, or a combination of random and block;

A is selected from the group consisting of

6. The material according to claim 2, wherein 0.003≦

y/z≦

50 and 0.02≦

x/(y+z)≦

21.

7. The material according to claim 2, wherein said material has a specific surface area of about 50-800 m²/g.

8. The material according to claim 2, wherein said material is hydrolytically stable at a pH of about 1 to about 13.

11. A separations device comprising a material according to claim 2.

12. The separations device according to claim 11, wherein said device is selected from the group consisting of chromatographic columns, thin layer plates, filtration membranes, sample cleanup devices, and microtiter plates.

14. The porous inorganic/organic homogenous copolymeric hybrid material of claim 2, wherein z=0 and the hybrid material is of the formula:

(A)_x(B)_y(B*)_y*

wherein the order of repeat units A, B, and B* may be random, block, or a combination of random and block;

A is selected from the group consisting of