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Microfluidic device and method of using same

  • US 9,211,537 B2
  • Filed: 11/07/2008
  • Issued: 12/15/2015
  • Est. Priority Date: 11/07/2007
  • Status: Expired due to Fees
First Claim
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1. A microfluidic device comprising:

  • a polymer substrate comprising a plurality of blind reaction chambers in coplanar array;

    a flow channel having an inlet at a first end and an outlet at a second end; and

    a vapor barrier substrate impermeable to water vapor and applied in a parallel plane to the plurality of blind reaction chambers and separated from the blind reaction chambers by a layer of polymer of the polymer substrate;

    wherein each blind reaction chamber is in fluid communication with the flow channel at a location in between the inlet and outlet, and wherein the polymer substrate is vapor permeable and the layer of polymer has a sufficient thickness to absorb gases displaced from the blind reaction chambers by a liquid that fills the blind reaction chambers and wherein the vapor barrier substrate and layer of polymer have a geometry that establishes a substantially two dimensional gradient of water vapor such that evaporation only occurs through one or more sides of the polymer substrate.

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