Biological sample measuring device

• US 9,213,015 B2
• Filed: 02/20/2012
• Issued: 12/15/2015
• Est. Priority Date: 02/23/2011
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Healthcare Holdings Co., Ltd.
• Inventors: Yoshioka, Eriko, Shinno, Teppei, Hironaka, Shouko
• Primary Examiner(s): Dieterle, Jennifer
• Application Number:
  US13/982,747
• Publication Number:
  US 20130306474A1
• Time in Patent Office: 1,394 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: C12M 1/34 Measuring or testing with condition measuring or sensing means, e.g. colony counters
• CPC Class Codes: C12Q 1/00 Measuring or testing processes involving enzymes, nucleic acids or microorganisms measuring or testing apparatus with condition measuring or sensing means, e.g. colony counters, C12M1/34; Compositions therefor; Processes of preparing such compositions
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: G01N 27/416 Systems G01N27/27 takes precedence
• CPC Class Codes: G01N 27/4175 Calibrating or checking the analyser
• CPC Class Codes: G01N 33/49 Blood chemical methods for determining blood cell populations G01N33/5094; chemical analysis of blood groups or blood types G01N33/80
• CPC Class Codes: G06F 2218/00 Aspects of pattern recognition specially adapted for signal processing
• CPC Class Codes: G16B 40/00 ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
• CPC Class Codes: H01J 49/0036 Step by step routines describing the handling of the data generated during a measurement

Abstract

A biological sample measuring device in which a deposited biological sample is introduced into a capillary, a biological sample measuring sensor in which a reagent and the biological sample provided is mounted, and the biological sample is measured. The biological sample measuring device comprises a mounting portion, a voltage application section, and a detection component. The biological sample measuring sensor is mounted to the mounting portion. The voltage application section applies a measurement voltage to a plurality of electrodes disposed along the capillary. The detection component eliminates the effect of seepage of the biological sample by pass-around at the end of the capillary, or the effect whereby the plasma component seeps into the reagent, and detects the degree to which the biological sample is introduced into the capillary, based on the output result for the voltage applied by the voltage application section to the electrodes.

Claims

1. A biological sample measuring device comprising:

a mounting portion;

a voltage application section configured to apply a voltage to a plurality of electrodes; and

a controller configured to;

determine an output result based on applying the voltage of the voltage application section to the electrodes,

detect a degree to which a biological sample is introduced into a capillary based on the output result, and

eliminate misdetection of the biological sample due to seepage or pass-around.

2. The biological sample measuring device according to claim 1, wherein:

the controller is further configured to;

detect an additional deposit of the biological sample,

determine that the capillary contains an insufficient quantity of the biological sample based on the degree to which the biological sample is introduced into the capillary, and

detect that the output result has exceeded a specific threshold after the controller has determined that the capillary contains an insufficient quantity of the biological sample.

3. The biological sample measuring device according to claim 1, wherein:

the electrodes include;

a first electrode disposed inside the capillary, and

a second electrode disposed closer to an inlet of the capillary than the first electrode in a region of the capillary where a reagent is provided;

the output result is determined based on applying the voltage between the first electrode and the second electrode; and

the controller is further configured to determine whether the capillary is in a properly filled state, or in a state in which pass-around or seepage has occurred, based on a function related to the output result.

4. The biological sample measuring device according to claim 1, wherein:

the electrodes include;

a first electrode disposed inside the capillary,

a second electrode disposed closer to an inlet of the capillary than the first electrode in a region of the capillary where a reagent is provided, and

a third electrode that is including;

a first portion of the third electrode disposed closer to the inlet of the capillary than the second electrode, and

a second portion of the third electrode disposed between the first and second electrodes;

the output result determined based on alternately applying the voltage between;

the first electrode and the third electrode, and

the first electrode and the second electrode,

the voltage applied for a predetermined length of time to each pair of electrodes; and

the controller is further configured to determine whether the capillary is in a properly filled state, or in a state in which pass-around or seepage has occurred, based on a function related the output result.

5. The biological sample measuring device according to claim 1, wherein:

the electrodes include;

a first electrode disposed inside the capillary,

a second electrode disposed closer to an inlet of the capillary than the first electrode in a region of the capillary where a reagent is provided, and

a third electrode including;

a first portion of the third electrode disposed closer to the inlet of the capillary than the second electrode, and

a second portion of the third electrode disposed between the first and second electrodes;

the output result is determined based on applying the voltage between the first electrode and the third electrode; and

the controller is further configured to determine whether the capillary is in a properly filled state, or in a state in which pass-around or seepage has occurred, based on a function related to the output result.

6. The biological sample measuring device according to claim 1, further comprising:

a display section configured to display information related to the biological sample; and

wherein the controller is further configured to;

determine a detection result based on the degree to which the biological sample is introduced into the capillary, and

display, on the display section, an indication recommending an additional deposit of the biological sample based on the detection result.

7. The biological sample measuring device according to claim 1, further comprising:

a display section configured to display information related to the biological sample,

wherein the controller is further configured to;

determine a detection result based on the degree to which the biological sample is introduced into the capillary, and

display, on the display section, an indication of a measurement error based on the detection result.

8. The biological sample measuring device according to claim 1, further comprising:

a biological sample measuring sensor including the capillary;

wherein the biological sample measuring sensor is configured to be removably mounted to the mounting portion.

9. The biological sample measuring device according to claim 1, wherein:

the electrodes include;

a first electrode including a first portion disposed inside the capillary,

a second electrode disposed closer to an inlet of the capillary than the first electrode in a region of the capillary where the reagent is provided, and

a third electrode including a first portion disposed closer to the inlet of the capillary than the second electrode; and

the controller is further configured to determine whether the capillary is in a properly filled state, or in a state in which pass-around or seepage has occurred, based on a function related to the output result.

10. The biological sample measuring device according to claim 9, wherein:

the output result is determined based on applying the voltage between the first electrode and the second electrode.

11. The biological sample measuring device according to claim 9, wherein:

the output result is determined based on alternately applying the voltage between;

the first electrode and the third electrode, and

the first electrode and the second electrode.

12. The biological sample measuring device according to claim 9, wherein:

the third electrode further includes a second portion disposed between the first and second electrodes.

13. The biological sample measuring device according to claim 12, wherein:

the output result is determined based on applying the voltage between the first electrode and the third electrode.

14. The biological sample measuring device according to claim 12, wherein:

the output result is determined based on alternately applying the voltage between;

the first electrode and the third electrode, and

the first electrode and the second electrode.

15. The biological sample measuring device according to claim 12, wherein:

the first electrode further includes a second portion disposed closer to the inlet of the capillary than the first portion of the third electrode.

16. The biological sample measuring device according to claim 15, wherein:

the output result is determined based on alternately applying the voltage between;

the first portion of the first electrode and the second portion of the third electrode, and

the second portion of the first electrode and the first portion of the third electrode.