Nicotine salt formulations for aerosol devices and methods thereof
First Claim
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1. A method of delivering nicotine to a user comprising deploying an electronic cigarette comprising a nicotine formulation that comprises nicotine, an acid, wherein the acid comprises pyruvic acid, salicylic acid, sorbic acid, lauric acid, levulinic acid, or benzoic acid, and a biologically acceptable liquid carrier, wherein:
- a. the nicotine formulation has a pH between 2.1-6.7;
b. the nicotine concentration is from about 2% (w/w) to about 6% (w/w);
c. operation of the electronic cigarette comprises heating at least a portion of the nicotine formulation to generate an inhalable aerosol comprising particle sizes from about 0.1 microns to about 5 microns; and
d. inhalation of the inhalable aerosol into the user'"'"'s lungs over a period of about 5 minutes at a rate of about one inhalation per 30 seconds results in a nicotine plasma Tmax from about 3 min to about 8 min.
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Abstract
A nicotine salt liquid formulation for generating an inhalable aerosol in an electronic cigarette comprising nicotine salt that forms about 0.5% to about 20% nicotine is provided.
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Citations
26 Claims
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1. A method of delivering nicotine to a user comprising deploying an electronic cigarette comprising a nicotine formulation that comprises nicotine, an acid, wherein the acid comprises pyruvic acid, salicylic acid, sorbic acid, lauric acid, levulinic acid, or benzoic acid, and a biologically acceptable liquid carrier, wherein:
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a. the nicotine formulation has a pH between 2.1-6.7; b. the nicotine concentration is from about 2% (w/w) to about 6% (w/w); c. operation of the electronic cigarette comprises heating at least a portion of the nicotine formulation to generate an inhalable aerosol comprising particle sizes from about 0.1 microns to about 5 microns; and d. inhalation of the inhalable aerosol into the user'"'"'s lungs over a period of about 5 minutes at a rate of about one inhalation per 30 seconds results in a nicotine plasma Tmax from about 3 min to about 8 min. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A method of delivering nicotine to a user comprising deploying an electronic cigarette comprising a nicotine formulation that comprises nicotine, an acid, wherein the acid comprises pyruvic acid, salicylic acid, sorbic acid, lauric acid, levulinic acid, or benzoic acid and a biologically acceptable liquid carrier, wherein:
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a. the nicotine formulation has a pH between 2.1-6.7 b. operation of the electronic cigarette comprises heating at least a portion of the nicotine formulation to generate an inhalable aerosol comprising particle sizes from about 0.1 microns to about 5 microns; c. inhalation of the inhalable aerosol into the user'"'"'s lungs over a period of about 5 minutes at a rate of about one inhalation per 30 seconds results in a nicotine plasma Tmax from about 3 min to about 8 min; d. the nicotine concentration is from about 2% (w/w) to about 6% (w/w); e. the nicotine formulation comprises monoprotonated nicotine; and f. the acid does not decompose at room temperature and does not decompose at the operating temperature of the electronic cigarette. - View Dependent Claims (13, 14)
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15. A method of delivering nicotine to a user comprising deploying an electronic cigarette comprising a nicotine formulation comprising nicotine and benzoic acid in a biologically acceptable liquid carrier, wherein:
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a. the nicotine formulation has a pH between 2.1-6.7; b. the nicotine concentration is from about 2% (w/w) to about 6% (w/w); c. operation of the electronic cigarette comprises heating at least a portion of the nicotine formulation to generate an inhalable aerosol comprising particle sizes from about 0.1 microns to about 5 microns; and d. inhalation of the inhalable aerosol into the user'"'"'s lungs over a period of about 5 minutes at a rate of about one inhalation per 30 seconds results in a nicotine plasma Tmax from about 5 min to about 8 min.
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16. A cartridge for use with an electronic cigarette comprising a fluid compartment configured to be in fluid communication with a heating element, the fluid compartment comprising a nicotine formulation that comprises nicotine and an acid, wherein the acid comprises pyruvic acid, salicylic acid, sorbic acid, lauric acid, levulinic acid, or benzoic acid, and a biologically acceptable liquid carrier, wherein:
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a. the nicotine formulation has a pH between 2.1-6.7 b. the nicotine concentration is from about 2% (w/w) to about 6% (w/w); c. operation of the electronic cigarette comprises heating at least a portion of the nicotine formulation to generate an inhalable aerosol comprising particle sizes from about 0.1 microns to about 5 microns; and
whereind. inhalation of the inhalable aerosol into the user'"'"'s lungs over a period of about 5 minutes at a rate of about one inhalation per 30 seconds results in a nicotine plasma Tmax from about 3 min to about 8 min. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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Specification