Uterine lavage for embryo retrieval

• US 9,216,037 B2
• Filed: 06/21/2013
• Issued: 12/22/2015
• Est. Priority Date: 06/21/2013
• Status: Active Grant

• Current Assignee: Butterfly Biosciences Incorporated
• Original Assignee: Previvo Genetics, LLC
• Inventors: Buster, John E., Cesario, Moses, Woodard, Steven Paul
• Primary Examiner(s): MATTHEWS, CHRISTINE HOPKINS
• Application Number:
  US13/924,520
• Publication Number:
  US 20140378753A1
• Time in Patent Office: 914 Days
• Field of Search: 600/33, 600/34
• US Class Current: 1/1
• CPC Class Codes: A61B 17/42 Gynaecological or obstetrical instruments or methods ligaturing clamps or clips for the umbilical cord A61B17/122; curettage A61B17/320708; dilators A61M29/00
• CPC Class Codes: A61B 17/435 for embryo or ova transplantation
• CPC Class Codes: A61B 2017/4216 Operations on uterus, e.g. endometrium
• CPC Class Codes: A61B 2050/185 Drawers
• CPC Class Codes: A61B 2050/311 Cases
• CPC Class Codes: A61B 2217/005 with suction drainage system
• CPC Class Codes: A61B 2217/007 with irrigation system
• CPC Class Codes: A61B 50/13 Trolleys, e.g. carts

Abstract

A device for recovering one or more blastocysts from the uterus of a human includes an outer guide member for insertion into a cervical canal of the human. The outer guide member includes a distal portion with an activatable seal for isolating the uterus from the external environment and defines a lumen having a longitudinal axis. The device also includes an inner catheter located within the lumen and slidable along the longitudinal axis of the lumen relative to the outer guide member. The inner catheter has a distal tip positionable distally of the seal to extend into the uterus and includes a fluid delivery lumen terminating at a distal fluid delivery port for delivering fluid into the uterus. The device defines a distal suction port for aspirating fluid and entrained blastocysts from the uterus. The distal fluid delivery port and the distal suction port are arranged such that, in use, fluid delivered from the distal fluid delivery port travels through the distal suction port to the uterus.

Claims

1. A process for recovering one or more blastocysts from the uterus of a human, comprising:

placing a device trans-vaginally into the cervical canal; and

cyclically delivering fluid through the device to the uterus in at least two cycles wherein

the first cycle comprises delivering a first amount of fluid to form a first puddle encompassing the one or more blastocysts and applying a vacuum to the uterus to aspirate fluid and entrained blastocysts within the first puddle from the uterus; and

the second cycle comprises delivering a larger amount of fluid into the uterus to form a second, larger puddle and applying a vacuum to the uterus to aspirate fluid from the uterus,

wherein a fluid delivery port for delivering fluid into the uterus and a suction port for aspirating fluid and entrained blastocysts from the uterus are provided such that in use fluid is deliverable from the fluid delivery port to travel through the suction port to the uterus.

2. The process of claim 1, wherein the fluid delivery port is non-circular in shape to provide directional control of fluid spray.

3. The process of claim 1, further comprising a controller programmed to automatically cyclically deliver lavage liquid to the uterus and apply vacuum to the device from a vacuum source remote from the device.

4. The process of claim 3, wherein the controller includes a pump for delivering the lavage liquid and a pump for applying the vacuum.

5. The process of claim 4, wherein the controller includes electro-mechanical means for controlling the delivery of lavage fluid and the application of vacuum.

6. The process of claim 3, wherein the controller is programmed to cyclically deliver varying amounts of lavage liquid to the uterus in three or more cycles with the amount of fluid delivered increasing in each subsequent cycle.