Composite material for tissue repair

• US 9,216,194 B2
• Filed: 08/19/2014
• Issued: 12/22/2015
• Est. Priority Date: 12/12/2006
• Status: Active Grant

• Current Assignee: Synthasome, Inc.
• Original Assignee: Synthasome, Inc.
• Inventors: Ratcliffe, Anthony
• Primary Examiner(s): DICKINSON, PAUL W
• Application Number:
  US14/462,897
• Publication Number:
  US 20140357716A1
• Time in Patent Office: 490 Days
• US Class Current: 1/1
• CPC Class Codes: A61F 2/08 Muscles; Tendons; Ligaments sutures A61B17/04
• CPC Class Codes: A61F 2/105 Skin implants, e.g. artificial skin
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2/30756 Cartilage endoprostheses A61F2/3603 takes precedence
• CPC Class Codes: A61F 2002/0894 Muscles
• CPC Class Codes: A61K 31/77 of oxiranes
• CPC Class Codes: A61L 26/0052 Mixtures of macromolecular compounds
• CPC Class Codes: A61L 26/008 Hydrogels or hydrocolloids
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/52 Hydrogels or hydrocolloids
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders

Abstract

The present disclosure provides a biocompatible composite and method for its use in repairing tissue defects, including defects in cartilage. The biocompatible composite includes a fibrous polymeric component and a polymerizable agent, which is capable of forming the biocompatible composite in situ at the site of a tissue defect. In embodiments, the repair site at which the biocompatible composite is to be applied may be treated with a priming agent, permitting polymerization of the polymerizable agent to the tissue located at the repair site.

Claims

1. A method comprising:

identifying a tissue defect in cartilage, a ligament or a tendon for repair;

applying a composite in combination with a polymerizable agent to the tissue defect, the composite including a fibrous polymeric component and a hydro gel formed in vitro on the fibrous polymeric component; and

reacting the polymerizable agent with tissue at the site of the defect in the absence of a priming agent.

2. An implant comprising:

a composite including a porous fibrous material and a hydrogel composition formed in vitro on the fibrous polymeric component; and

a polymerizable composition applied to the composite, the polymerizable composition including a polymerizable agent capable of covalently bonding to tissue in situ at a site of a tissue defect in cartilage, ligament, or tendon in the absence of a priming agent.

3. The biocompatible composite of claim 2, wherein the hydrogel comprises a therapeutic agent.

4. The biocompatible composite of claim 2, wherein the polymerizable composition comprises a therapeutic agent.

5. The biocompatible composite of claim 2, wherein the polymerizable agent includes at least one free radical polymerizable group selected from the group consisting of acrylates, diacrylates, oligoacrylates, dimethacrylates, oligomethacrylates, and combinations thereof.

6. The biocompatible composite of claim 2, wherein the polymerizable composition includes a material that is polymerizable when exposed to a source of ultraviolet radiation, an enzymatic agent or to a chemical agent.

7. The biocompatible composite of claim 2, wherein the porous fibrous material is a non-woven web, a mesh or a felt.