Methods and systems for modulating medicants using acoustic energy
First Claim
1. A method for steering a medicant through a tissue, the tissue having a first region located at a first depth and a second region adjacent to the first region and located at a second depth, the method comprising the steps of:
- presenting a medicant to the first region of the tissue;
focusing, using a source of ultrasound energy, a first acoustic energy from the source to the first region, the first acoustic energy having a first spatial and temporal energy profile configured to provide cavitation and radiation force, thereby initiating cavitation and radiation force, thereby moving the medicant from the first region to the second region;
focusing, using the source of ultrasound energy, a second acoustic energy from the source to the second region, the second acoustic energy having a second spatial and temporal energy profile configured to enhance effectiveness of the medicant, thereby enhancing the effectiveness of the medicant in the second region.
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Accused Products
Abstract
This invention provides methods and systems uniquely capable of enhancing medicant delivery and/or effectiveness through the use of energy to predictably disrupt membranes and mechanically and thermally modulate cells and tissues. In exemplary embodiments, the methods and systems disclosed herein are capable of modulating multiple layers of tissue. In an exemplary embodiment, the energy is acoustic energy (e.g., ultrasound). In other exemplary embodiments, the energy is photon based energy (e.g., IPL, LED, laser, white light, etc.), or other energy forms, such radio frequency electric currents, or various combinations of acoustic energy, electromagnetic energy and other energy forms or energy absorbers such as cooling. Medicants can be first introduced to the region of interest by diffusion, circulation, and/or injection. An exemplary system for enhancing medicant delivery and/or effectiveness comprises a control system, a probe, and a display or indicator system. Imaging and/or monitoring may alternatively be coupled and/or co-housed with an ultrasound system contemplated by the present invention.
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Citations
13 Claims
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1. A method for steering a medicant through a tissue, the tissue having a first region located at a first depth and a second region adjacent to the first region and located at a second depth, the method comprising the steps of:
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presenting a medicant to the first region of the tissue; focusing, using a source of ultrasound energy, a first acoustic energy from the source to the first region, the first acoustic energy having a first spatial and temporal energy profile configured to provide cavitation and radiation force, thereby initiating cavitation and radiation force, thereby moving the medicant from the first region to the second region; focusing, using the source of ultrasound energy, a second acoustic energy from the source to the second region, the second acoustic energy having a second spatial and temporal energy profile configured to enhance effectiveness of the medicant, thereby enhancing the effectiveness of the medicant in the second region. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for delivering a medicant to a region of interest within a tissue, the tissue having a first region located at a first depth, the region of interest located adjacent to the first region and at a second depth, the method comprising the steps of:
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coupling an ultrasound probe to the tissue, the ultrasound probe configured to focus acoustic energy into the first region and the region of interest; presenting a medicant to the first region of the tissue; focusing, using the probe, a first acoustic energy to the first region, wherein said first acoustic energy has a first spatial and temporal energy profile configured to provide cavitation and radiation force in the first region that moves the medicant from the first region to the region of interest, thereby creating cavitation and radiation force in the first region and moving the medicant from the first region to the region of interest; and focusing, using the probe, a second acoustic energy to the region of interest, wherein the second acoustic energy has a second spatial and temporal energy profile configured to provide a thermal effect in the region of interest that enhances the effectiveness of the medicant, thereby creating the thermal effect in the region of interest and enhancing the effectiveness of the medicant.
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11. A method for delivering a medicant to a portion of skin beneath a stratum corneum, the method comprising:
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applying a medicant to a surface of the portion of skin stratum corneum; coupling an ultrasound source to the medicant and the portion of skin; focusing a first acoustic energy emitted by the ultrasound source to a first depth beneath the stratum corneum, wherein the first acoustic energy has a first spatial and temporal energy profile configured to provide cavitation and radiation force, thereby delivering the medicant across the stratum corneum to the first depth beneath the stratum corneum; and focusing a second acoustic energy emitted by the ultrasound source into a second depth beneath the stratum corneum, wherein the second acoustic energy has a second spatial and temporal energy profile configured to provide cavitation and radiation force, thereby delivering the medicant from the first depth to the second depth beneath the stratum corneum, wherein the first acoustic energy is different than the second acoustic energy. - View Dependent Claims (12, 13)
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Specification