Method and apparatus for controlling neural stimulation during disordered breathing

• US 9,216,291 B2
• Filed: 06/05/2013
• Issued: 12/22/2015
• Est. Priority Date: 08/30/2006
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Lee, Kent, Libbus, Imad, Caparso, Anthony V., Kwok, Jonathan, Pu, Yachuan, Haefner, Paul A., James, Kristofer J.
• Primary Examiner(s): Heller, Tammie K
• Application Number:
  US13/910,359
• Publication Number:
  US 20130268030A1
• Time in Patent Office: 930 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 5/0215 by means inserted into the body catheters A61M25/00
• CPC Class Codes: A61B 5/08 Detecting, measuring or recording devices for evaluating the respiratory organs A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/0816 Measuring devices for examining respiratory frequency measuring frequency of electric signals G01R23/00
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61B 5/4818 Sleep apnoea
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/3614 based on impedance measurement

Abstract

A neural stimulation system controls the delivery of neural stimulation using a respiratory signal as a therapy feedback input. The respiratory signal is used to increase the effectiveness of the neural stimulation, such as vagal nerve stimulation, while decreasing potentially adverse side effects in respiratory functions. In one embodiment, the neural stimulation system detects apnea and, in response, adjusts the delivery of the neural stimulation pulses and/or delivers a respiratory therapy treating the detected apnea.

Claims

1. A neural stimulation system, comprising:

an implantable medical device including;

a therapy output device configured to deliver a neural stimulation therapy treating a non-respiratory disorder;

a therapy delivery controller coupled to the therapy output device, the therapy delivery controller configured to control the delivery of the neural stimulation therapy treating the non-respiratory disorder;

a respiratory signal input configured to receive a respiratory signal;

a respiratory disorder detector coupled to the respiratory signal input, the respiratory disorder detector configured to detect a respiratory disorder using the respiratory signal and determine whether the respiratory disorder is caused or worsened by the neural stimulation therapy treating the non-respiratory disorder; and

a therapy adjustment module coupled to the therapy delivery controller and the respiratory disorder detector, the therapy adjustment module configured to adjust the delivery of the neural stimulation therapy treating the non-respiratory disorder in response to a detection of the respiratory disorder caused or worsened by the neural stimulation therapy treating the non-respiratory disorder.

2. The system of claim 1, wherein the therapy adjustment module is configured to decrease the intensity of the neural stimulation therapy treating the non-respiratory disorder in response to the detection of the respiratory disorder caused or worsened by the neural stimulation therapy treating the non-respiratory disorder.

3. The system of claim 1, wherein the therapy adjustment module is configured to provide feedback control to the delivery of the neural stimulation therapy treating the non-respiratory disorder using a non-respiratory physiological parameter as an input, the feedback control configured to maintain the non-respiratory physiological parameter within a target range.

4. The system of claim 1, wherein the therapy output device is further configured to deliver a respiratory therapy treating the respiratory disorder, the therapy delivery controller is further configured to control the delivery of the respiratory therapy, and the therapy adjustment module is further configured to start delivery of the respiratory therapy in response to the detection of the respiratory disorder caused or worsened by the neural stimulation therapy treating the non-respiratory disorder.

5. The system of claim 4, wherein the therapy output circuit is configured to deliver a further neural stimulation therapy treating the respiratory disorder, and the therapy adjustment module is configured to start the further neural stimulation therapy in response to the detection of the respiratory disorder caused or worsened by the neural stimulation therapy treating the non-respiratory disorder.

6. The system of claim 1, wherein the respiratory signal is indicative of respiratory cycles, and the implantable medical device further comprises a synchronization module coupled to the therapy delivery controller and the respiratory signal input, the synchronization module configured to synchronize the delivery of the neural stimulation therapy treating the non-respiratory disorder to the respiratory cycles.

7. The system of claim 6, wherein the synchronization module comprises:

a respiratory fiducial point detector configured to detect respiratory fiducial points from the respiratory signal; and

a delay timer configured to time a delay interval starting with each of the detected respiratory fiducial points,

and wherein the therapy delivery controller is configured to cause the therapy output circuit to deliver a burst of neural stimulation pulses when the delay interval expires.

8. The system of claim 7, wherein the respiratory fiducial point detector comprises a peak detector configured to detect peaks of the respiratory signal, and the delay timer is configured to time a delay interval starting with each of the detected peaks of the respiratory signal.

9. The system of claim 1, wherein the respiratory disorder detector is configured to detect at least one of apnea, hypopnea, or dyspnea.

10. The system of claim 1, wherein the respiratory disorder detector is configured to detect abnormal values of one or more respiratory parameters including at least one of a respiratory rate, tidal volume, or minute ventilation.

11. A method for neural stimulation, the method comprising:

delivering a neural stimulation therapy treating a non-respiratory disorder from an implantable medical device;

sensing a respiratory signal using an implantable respiratory sensor;

detecting a respiratory disorder using the respiratory signal using the implantable medical device, including determining whether the respiratory disorder is caused or worsened by the neural stimulation therapy treating the non-respiratory disorder; and

adjusting the delivery of the neural stimulation therapy treating the non-respiratory disorder in response to a detection of the respiratory disorder caused or worsened by the neural stimulation therapy treating the non-respiratory disorder.

12. The method of claim 11, wherein adjusting the delivery of the neural stimulation therapy treating the non-respiratory disorder comprises decreasing an intensity of the neural stimulation therapy treating the non-respiratory disorder in response to the detection of the respiratory disorder caused or worsened by the neural stimulation therapy treating the non-respiratory disorder.

13. The method of claim 11, further comprising:

monitoring a non-respiratory response to the delivery of the neural stimulation therapy treating the non-respiratory disorder; and

adjusting the neural stimulation therapy treating the non-respiratory disorder in response to the non-respiratory response falling out of a target range.

14. The method of claim 11, further comprising delivering a respiratory therapy treating the respiratory disorder, and starting the delivery of the respiratory therapy treating the respiratory disorder in response to the detection of the respiratory disorder caused or worsened by the neural stimulation therapy treating the non-respiratory disorder.

15. The method of claim 14, wherein delivering the respiratory therapy treating the respiratory disorder comprises delivering a further neural stimulation therapy treating the respiratory disorder caused or worsened by the neural stimulation therapy treating the non-respiratory disorder.

16. The method of claim 14, wherein delivering the respiratory therapy comprises delivering a cardiac pacing therapy.

17. The method of claim 14, wherein the respiratory signal is indicative of respiratory cycles, and further comprising synchronizing the delivery of the neural stimulation therapy treating the non-respiratory disorder to the respiratory cycles.

18. The method of claim 17, wherein synchronizing the delivery of the neural stimulation therapy treating the non-respiratory disorder to the respiratory cycles comprises:

detecting predetermined-type respiratory fiducial points from the respiratory signal;

starting a delay interval with each of the detected predetermined-type respiratory fiducial points; and

delivering a burst of neural stimulation pulses when the delay interval expires.

19. The method of claim 11, wherein detecting the respiratory disorder comprises detecting at least one of apnea, hypopnea, or dyspnea.

20. The method of claim 11, wherein detecting the respiratory disorder comprises detecting abnormal values of one or more respiratory parameters including at least one of a respiratory rate, tidal volume, or minute ventilation.