Hedgehog pathway modulators
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Abstract
The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
15 Citations
18 Claims
- 1. A compound having the structure of Formula I:
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18. A compound selected from:
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5-[(6-methanesulfonyl-5,6,7,8-tetrahydro-2,6-naphthyridin-1-yl)amino]-2-methyl-N-phenylbenzamide; and 5-({7-methanesulfonyl-5H,6H,7H,8H-pyrido[3,4-d]pyrimidin-4-yl}amino)-2-methyl-N-phenylbenzamide.
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Specification