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Oscillating cell culture bioreactor

  • US 9,217,129 B2
  • Filed: 02/08/2008
  • Issued: 12/22/2015
  • Est. Priority Date: 02/09/2007
  • Status: Active Grant
First Claim
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1. A bioreactor comprisingone or more gas permeable, closed-loop chambers which can contain fluid and gases and a tissue engineering scaffold for cell or tissue culture;

  • a tissue engineering scaffold or tissue engineering matrix secured directly to the wall of the closed-loop chamber or placed within a means for retaining the scaffold which is secured directly to the wall of closed-loop chamber so that fluid, cells and gases are forced through the entire thickness of the scaffold; and

    an oscillator and controller for moving the gas permeable, closed-loop chamber bidirectionally along an axis horizontal to an axis normal to the closed-loop chamber to force cells and fluid within the gas permeable, closed-loop chamber by convective flow through the secured tissue engineering scaffold.

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