Biomarker normalization
First Claim
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1. A fluid measuring system for measuring osmolarity of a sample fluid and concentration of a biomarker within the sample fluid, said system comprising:
- a. a sample chip configured to contain an aliquot volume of a sample fluid, and which processes (i) energy properties of the sample fluid to prepare an osmolarity output signal which corresponds to osmolarity of the sample fluid, and (ii) chemical properties of the sample fluid to prepare a biomarker output signal which corresponds to concentration of a biomarker within the sample fluid; and
b. a processing device that;
receives the osmolarity output signal from the sample region and processes the osmolarity output signal to produce an osmolarity value for the sample fluid; and
receives the biomarker output signal from the sample region and processes the biomarker output signal to produce a biomarker concentration value for the sample fluid;
wherein the biomarker is;
IgE, IgA, IgG, IgM, glucose, insulin, lactoferrin, a cytokine, a hormone, a hormone metabolite, an infectious disease phenotype, a nucleic acid, a protein, or a lipid fraction.
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Abstract
A fluid sample is measured with a tear film measuring system that includes a processing device that receives a sample chip comprising a sample region configured to contain an aliquot volume of sample fluid, the processing device configured to perform analyzes of osmolarity and of one or more biomarkers within the sample fluid, wherein the analysis of biomarkers includes normalization of biomarker concentration values.
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Citations
39 Claims
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1. A fluid measuring system for measuring osmolarity of a sample fluid and concentration of a biomarker within the sample fluid, said system comprising:
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a. a sample chip configured to contain an aliquot volume of a sample fluid, and which processes (i) energy properties of the sample fluid to prepare an osmolarity output signal which corresponds to osmolarity of the sample fluid, and (ii) chemical properties of the sample fluid to prepare a biomarker output signal which corresponds to concentration of a biomarker within the sample fluid; and b. a processing device that;
receives the osmolarity output signal from the sample region and processes the osmolarity output signal to produce an osmolarity value for the sample fluid; and
receives the biomarker output signal from the sample region and processes the biomarker output signal to produce a biomarker concentration value for the sample fluid;wherein the biomarker is;
IgE, IgA, IgG, IgM, glucose, insulin, lactoferrin, a cytokine, a hormone, a hormone metabolite, an infectious disease phenotype, a nucleic acid, a protein, or a lipid fraction.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. A method of measuring osmolarity of a sample fluid and concentration of a biomarker within the sample fluid, the method comprising:
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a. receiving from a sample region of a sample chip an osmolarity output signal that corresponds to osmolarity of the sample fluid, and a biomarker output signal that corresponds to concentration of a biomarker within the sample fluid, wherein the biomarker is selected from;
IgE, IgA, IgG, IgM, glucose, insulin, lactoferrin, a cytokine, a hormone, a hormone metabolite, an infectious disease phenotype, a nucleic acid, a protein, or a lipid fraction; andb. processing the osmolarity output signal to produce an osmolarity value for the sample fluid and the biomarker output signal to produce a biomarker concentration value for the sample fluid. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39)
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Specification