Protein and lipid biomarkers providing consistent improvement to the prediction of type 2 diabetes
First Claim
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1. A method of evaluating risk for developing a diabetic condition, the method comprising:
- (a) obtaining biomarker measurement data for an individual from at least one biological sample of the individual;
wherein the biomarkers comprise;
(i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2; and
(b) evaluating the individual'"'"'s risk for developing a diabetic condition based on an output from a model, wherein the model is executed based on an input of the biomarker measurement data;
orwherein the model comprises the measurements of biomarkers by fitting data from a longitudinal study of a population of individuals and the fitted data comprises levels of the biomarkers and conversion to Diabetes in the longitudinal study of the population of individuals.
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Abstract
The invention relates to biomarkers associated with Diabetes, including protein and lipid metabolite biomarkers, methods of using the biomarkers to determine the risk that an individual will develop Diabetes, and methods of screening a population to identify persons at risk for developing Diabetes and other pre-diabetic conditions.
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Citations
20 Claims
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1. A method of evaluating risk for developing a diabetic condition, the method comprising:
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(a) obtaining biomarker measurement data for an individual from at least one biological sample of the individual;
wherein the biomarkers comprise;
(i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2; and(b) evaluating the individual'"'"'s risk for developing a diabetic condition based on an output from a model, wherein the model is executed based on an input of the biomarker measurement data;
orwherein the model comprises the measurements of biomarkers by fitting data from a longitudinal study of a population of individuals and the fitted data comprises levels of the biomarkers and conversion to Diabetes in the longitudinal study of the population of individuals. - View Dependent Claims (2, 3, 4, 5, 6, 13, 14, 15, 17, 18, 19)
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7. A kit comprising reagents for measuring a group of biomarkers, wherein the biomarkers comprise:
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(i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2.
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8. A computer readable medium having computer executable instructions for evaluating an individual'"'"'s risk for developing a diabetic condition, the computer readable medium comprising:
- a routine, stored on the computer readable medium and adapted to be executed by a processor, to store biomarker measurement data representing measurements of at least the following;
(i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2; anda routine stored on the computer readable medium and adapted to be executed by a processor to analyze the biomarker measurement data of the individual to evaluate a risk for developing a diabetic condition.
- a routine, stored on the computer readable medium and adapted to be executed by a processor, to store biomarker measurement data representing measurements of at least the following;
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9. A medical diagnostic test system for evaluating risk for developing a diabetic condition, the system comprising:
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a data collection tool adapted to collect biomarker measurement data representative of measurements of biomarkers in at least one biological sample from the individual, wherein the biomarkers comprise;
(i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2; andan analysis tool comprising a statistical analysis engine adapted to generate a representation of a correlation between a risk for developing a diabetic condition and measurements of the biomarkers, wherein the representation of the correlation is adapted to be executed to generate a result; and an index computation tool adapted to analyze the result to determine the individual'"'"'s risk for developing a diabetic condition and represent the result as an index value.
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10. A method of developing a model for evaluating an individual'"'"'s risk for developing a diabetic condition, the method comprising:
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obtaining biomarker measurement data, wherein the biomarker measurement data is representative of measurements of biomarkers from a population and includes endpoints of the population;
wherein the biomarkers for which measurement data is obtained comprise;
(i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2;inputting the biomarker measurement data of at least a subset of the population into a model; and training the model for endpoints using the inputted biomarker measurement data to derive a representation of a correlation between a risk of developing a diabetic condition and measurements of biomarkers in at least one biological sample from the individual.
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11. A method of evaluating an individual'"'"'s current diabetic condition, the method comprising:
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obtaining biomarker measurement data from at least one biological sample of the individual, wherein the biomarkers comprise;
(i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2; andevaluating the current diabetic condition of the individual based on an output from a model, wherein the model is executed based on an input of the biomarker measurement data.
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12. A method of evaluating a diabetic disease surrogate endpoint for an individual, the method comprising:
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obtaining biomarker measurement data from at least one biological sample of the individual;
wherein the biomarkers comprise;
(i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2; andevaluating a diabetic disease surrogate endpoint in the individual based on an output from a model, wherein the model is executed based on an input of the biomarker measurement data.
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16. A method of evaluating an individual'"'"'s current diabetic condition comprising:
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obtaining biomarker measurement data from at least one biological sample of the individual, wherein the biomarkers comprise;
(i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2; andevaluating the current status of a diabetic condition in the individual based on an output from a model, wherein the model is executed based on an input of the biomarker measurement data. - View Dependent Claims (20)
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Specification