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Protein and lipid biomarkers providing consistent improvement to the prediction of type 2 diabetes

  • US 9,217,747 B2
  • Filed: 10/28/2010
  • Issued: 12/22/2015
  • Est. Priority Date: 10/29/2009
  • Status: Expired due to Fees
First Claim
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1. A method of evaluating risk for developing a diabetic condition, the method comprising:

  • (a) obtaining biomarker measurement data for an individual from at least one biological sample of the individual;

    wherein the biomarkers comprise;

    (i) glucose, (ii) protein biomarkers adiponectin, ferritin, and insulin, and (iii) at least one lipid metabolite selected from the lipid metabolites in Table 2; and

    (b) evaluating the individual'"'"'s risk for developing a diabetic condition based on an output from a model, wherein the model is executed based on an input of the biomarker measurement data;

    orwherein the model comprises the measurements of biomarkers by fitting data from a longitudinal study of a population of individuals and the fitted data comprises levels of the biomarkers and conversion to Diabetes in the longitudinal study of the population of individuals.

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