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Systems and methods for identifying unknown drug targets via adverse event data

  • US 9,218,457 B2
  • Filed: 04/13/2012
  • Issued: 12/22/2015
  • Est. Priority Date: 01/06/2012
  • Status: Active Grant
First Claim
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1. A method for building a molecular entity model comprising unknown drug target interactions identified via adverse event data, comprising:

  • receiving, by an analyzer module executed by a processor of a computing device from a user, an identification of a first drug having one or more unknown target proteins;

    identifying, by the analyzer module from a medication information database stored in a computer-readable storage medium, a second drug related to the first drug;

    retrieving, by the analyzer module from an adverse event database representing physiological reactions from interaction of molecular entities with pharmaceutical compounds of drugs stored in the computer-readable storage medium, a first side effect profile associated with the first drug, and a second side effect profile associated with the second drug;

    generating, by the analyzer module, a third side effect profile comprising a subset of the first side effect profile not shared by the second side effect profile;

    identifying, by the analyzer module from the adverse event database, a third drug having a fourth side effect profile comprising the third side effect profile;

    retrieving, by the analyzer module from the medication information database, one or more target proteins of the third drug not targeted by the second drug; and

    building, by the analyzer module, a molecular entity model with the retrieved one or more target proteins as potential target proteins of the first drug.

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