System, method, and computer program product for simulating epicardial electrophysiology procedures

• US 9,218,752 B2
• Filed: 02/18/2011
• Issued: 12/22/2015
• Est. Priority Date: 02/18/2010
• Status: Active Grant

• Current Assignee: University of Virginia Patent Foundation (University of Virginia)
• Original Assignee: University of Virginia Patent Foundation (University of Virginia)
• Inventors: Gillies, George, Gyurjyan, Harutyun V., Mahapatra, Srijoy, Tucker-Schwartz, Jason M.
• Primary Examiner(s): Utama, Robert J
• Application Number:
  US13/579,882
• Publication Number:
  US 20130108999A1
• Time in Patent Office: 1,768 Days
• Field of Search: 434/262
• US Class Current: 1/1
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: G09B 23/28 for medicine
• CPC Class Codes: G09B 23/30 Anatomical models G09B23/281 - G09B23/288 take precedence
• CPC Class Codes: G09B 23/303 specially adapted to simulate circulation of bodily fluids

Abstract

An aspect of various systems and methods provides, but not limited thereto, novel means for simulating physiological systems and processes in vitro in order to test surgical devices and train practitioners in the use of surgical devices. An aspect of various embodiments further provides in vitro anatomical components, such as a thorax, lungs, heart and pericardium, configured to contain at least one fluid having a pressure-frequency profile that may mimic typical pressure-frequency waveforms of in vivo anatomical fluids. A model communication system may be used to communicate the desired pressure-frequency profiles to the in vitro anatomical fluids. In a further aspect of various embodiments, an access device, e.g. a surgical instrument, configured to sense pressure, frequency, and/or a pressure-frequency profile may be inserted into one or more anatomical components of the in vitro model in order to test the instrument and/or train a practitioner in proper use of the instrument. An access device communication system may be used to communicate data to the practitioner. This data may include, for example, pressure-frequency data and/or the location of a portion of the access device with respect to the various in vitro anatomical components.

Claims

1. An in vitro model system, said system comprising:

a thoracic cavity;

lungs disposed within said thoracic cavity;

said lungs configured to contain a lung fluid having a lung pressure-frequency profile;

a heart disposed within said thoracic cavity;

said heart configured to contain a cardiac fluid having a cardiac pressure frequency profile; and

a pericardium disposed within said thoracic cavity and configured to at least partially surround said heart;

said pericardium configured to contain—

between said pericardium and said heart—

a pericardial fluid having a pericardial pressure-frequency profile.

2. The model system of claim 1, further comprising:

a model communication system for providing at least one of the following;

the lung pressure-frequency profile, the cardiac pressure-frequency profile, and/or the pericardial pressure-frequency profile.

3. The model system of claim 2, wherein:

said model communication system is configured to pump at least one of the following;

the lung fluid, the cardiac fluid, and/or the pericardial fluid.

4. The model system of claim 2, further comprising:

a controller;

a motor;

an actuator; and

a pumping mechanism,

wherein;

said controller is configured to receive data representing the at least one the pressure frequency profile and communicate with said motor;

said motor is configured to communicate with said controller and said actuator;

said actuator is configured to communicate with said motor and said pumping mechanism; and

said pumping mechanism is configured to communicate with said actuator and at least one of the following;

the lung fluid, the cardiac fluid, and/or the pericardial fluid.

5. The model system of claim 2, wherein the at least one pressure-frequency profiles is a function of:

respiratory parameters and/or cardiac parameters.

6. The model system of claim 1, wherein:

the lung pressure-frequency profile mimics a subject breathing or intubation waveform;

the cardiac pressure-frequency profile mimics a subject cardiac waveform; and

the pericardial pressure-frequency profile mimics the sum of at least;

a component or damped component of the subject breathing or intubation waveform; and

a component or damped component of the subject cardiac waveform.

7. The model system of claim 1, further comprising:

a fluid source;

an aperture in at least one of said lungs, said heart, or said pericardium; and

a sealed connective apparatus between said fluid source and said aperture in at least one of said lungs, said heart, or said pericardium.

8. The model system of claim 1, further comprising:

an access device configured to enter one or more of said thoracic cavity, said lungs, said heart, and/or said pericardium,

wherein said system is configured for testing said access device or training a user of said access device.

9. The model system of claim 8, wherein said access device comprises at least one of a surgical instrument, a needle, a probe, a catheter, or a minimally invasive device, and wherein said access device is further configured to sense a pressure profile and/or a pressure-frequency profile.

10. The model system of claim 1, wherein:

said pericardium is sealed; and

the pericardial pressure-frequency profile results from communication of said pericardium and/or the pericardial fluid with said lungs and/or said heart.

11. An in vitro model system, said system comprising:

a set of anatomical components configured to contain at least one fluid;

at least one pressure-frequency profile; and

a model communication system for providing said at least one pressure-frequency profile to said at least one fluid,

wherein said set of anatomical components comprises;

a lung fluid having a lung pressure-frequency profile;

a cardiac fluid having a cardiac pressure-frequency profile; and

a pericardial fluid having a pericardial pressure-frequency profile.

12. The model system of claim 11, wherein:

said set of anatomical components comprises at least one or more of the following;

a thoracic cavity, lungs, a heart, a pericardium, a spine, one or more ribs, a sternum, and/or skin.

13. The model system of claim 11, wherein:

the lung pressure-frequency profile mimics a subject breathing or intubation waveform;

the cardiac pressure-frequency profile mimics a subject cardiac waveform; and

the pericardial pressure-frequency profile mimics the sum of at least;

a component or damped component of the subject breathing or intubation waveform; and

a component or damped component of the subject cardiac waveform.

14. The model system of claim 11, further comprising:

a controller;

a motor;

an actuator; and

a pumping mechanism,

wherein;

said controller configured to receive data representing said at least one pressure frequency profile and to communicate with said motor;

said motor configured to communicate with said controller and said actuator;

said actuator configured to communicate with said motor and said pumping mechanism; and

said pumping mechanism is configured to communicate with said actuator and the at least one fluid.

15. An in vitro modeling method, said method comprising:

providing a thoracic cavity;

providing lungs disposed within said thoracic cavity, wherein said lungs contain a lung fluid;

applying a lung pressure-frequency profile to the lung fluid;

providing a heart disposed within said thoracic cavity, wherein said heart contains a cardiac fluid;

applying a cardiac pressure-frequency profile to said cardiac fluid;

providing a pericardium disposed within said thoracic cavity, wherein said pericardium at least partially surrounds said heart, and wherein said pericardium contains a pericardial fluid between said pericardium and said heart; and

applying a pressure-frequency profile to said pericardial fluid.

16. The method of claim 15, wherein said application of said lung pressure-frequency profile, said cardiac pressure-frequency profile, and said pericardial pressure-frequency profile comprises:

pumping at least one of the following;

the lung fluid, the cardiac fluid, or the pericardial fluid.

17. The method of claim 15, wherein:

the lung pressure-frequency profile mimics a subject breathing or intubation waveform;

the cardiac pressure-frequency profile mimics a subject cardiac waveform; and

the pericardial pressure-frequency profile mimics the sum of at least;

a component or damped component of the subject breathing or intubation waveform; and

a component or damped component of the subject cardiac waveform.

18. The method of claim 15, further comprising:

providing an access device that enters one or more of said thoracic cavity, said lungs, said heart, and/or said pericardium;

sensing at least one of a pressure profile and a pressure-frequency profile with said access device.