Compositions and methods for measurement of oxygen saturation in blood filled structures

• US 9,220,450 B2
• Filed: 06/18/2013
• Issued: 12/29/2015
• Est. Priority Date: 06/18/2012
• Status: Expired due to Fees

• Current Assignee: Eso -Technologies, Inc.
• Original Assignee: Eso -Technologies, Inc.
• Inventors: Atlee, John L., Gorski, Stephen H., Reinke, Bonnie J., Reikersdorfer, Christian G., Palatnik, Eugene, Bezrukova, Elena, Bohachek, Michael M.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US14/117,474
• Publication Number:
  US 20150112172A1
• Time in Patent Office: 924 Days
• US Class Current: 1/1
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/0247 Pressure sensors
• CPC Class Codes: A61B 5/01 Measuring temperature of body parts ; Diagnostic temperature sensing, e.g. for malignant or inflamed tissue clinical contact thermometers G01K13/20
• CPC Class Codes: A61B 5/02055 Simultaneously evaluating both cardiovascular condition and temperature
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/1459 invasive, e.g. introduced into the body by a catheter A61B5/1464 takes precedence
• CPC Class Codes: A61B 5/285 Endotracheal, oesophageal or gastric probes
• CPC Class Codes: A61B 5/287 Holders for multiple electrodes, e.g. electrode catheters for electrophysiological study [EPS]
• CPC Class Codes: A61B 5/6853 with a balloon
• CPC Class Codes: A61B 5/72 Signal processing specially adapted for physiological signals or for diagnostic purposes character recognition, recognising digital ink, document-oriented image-based pattern recognition G06V30/00; recognition or understanding of postal images G06V30/424
• CPC Class Codes: A61B 5/7282 Event detection, e.g. detecting unique waveforms indicative of a medical condition A61B5/4094, A61B5/4818, A61B5/349, A61B5/0823 take precedence
• CPC Class Codes: A61B 5/742 using visual displays A61B5/339 takes precedence
• CPC Class Codes: A61B 7/023 for introduction into the body, e.g. into the oesophagus oesophageal ECG probes A61B5/285

Abstract

Provided herein is technology relating to medical monitoring of physiologic parameters, and particularly, but not exclusively, relating to compositions, methods and systems for the measurement of venous and arterial oxygen saturation in the blood of blood-filled anatomical structures.

Claims

1. A method for measuring blood oxygen saturation in a blood-filled structure comprising:

a) providing a system comprising;

1) at least one oximeter sensor comprising;

i) at least two light sources of differing wavelength;

ii) at least one photodetector; and

iii) a sensor housing comprising;

a′

) a flexible tubular member;

b′

) an optically transparent electrically isolated sheath; and

c′

) a cable comprising at least one connector;

2) a processor comprising;

i) a controller adapted for analyzing a plurality of signals from said oximeter sensor, calculating oxygen saturation values from the signals, and generating a distribution of the relative frequency of occurrence of oxygen saturations obtained within defined intervals of oxygen saturation at a plurality of predetermined averaging intervals; and

3) a display configured to output the distribution calculated by the processor;

b) positioning said oximeter sensor in a position adjacent to a blood-filled structure of a subject while displaying said distribution and using said displayed information to optimize said positioning relative to said blood-filled structure; and

c) measuring said blood oxygen saturation in said blood filled structure of said subject with said oximeter sensor at the optimized position.

2. The method of claim 1, wherein said subject is a mammal.

3. The method of claim 2, wherein said mammal is a human.

4. The method of claim 1, wherein said position is an esophageal position.

5. The method of claim 1, wherein said distribution permits determining whether said blood-filled structure is filled with venous blood, with arterial blood or with mixed venous and arterial blood.

6. The method of claim 1, wherein said blood-filled structure is the inferior vena cava, the right atrium, the pulmonary artery or the left atrium.

7. The method of claim 1, wherein the optical axis of said at least two light sources and said at least one detector are co-planar with the central axis of said tubular member.

8. The method of claim 1, wherein the optical center of said at least two light sources and the optical center of said at least one detector are at least 12 millimeters apart.

9. The method of claim 1, wherein said at least two light sources are light emitting diodes (LEDs) with wavelengths from 500 nanometers to 1100 nanometers.

10. The method of claim 1, wherein said at least two light sources are laser diodes with wavelengths from 500 nanometers to 1100 nanometers.

11. The method of claim 1, wherein the optical axis of said at least two light sources and said at least one detector are perpendicular to the central axis of said tubular member.

12. The method of claim 1, wherein the optical center of said at least two light sources and the optical center of said at least one detector are at least 4 millimeters apart.

13. The method of claim 1, wherein said sensor housing comprises a sheath, a sleeve comprising said at least two light sources, and said at least one detector.

14. The method of claim 1, wherein said flexible tubular member contains at least one internal lumen.

15. The method of claim 14, wherein said lumen is open at both ends of said tubular member.

16. The method of claim 15, wherein the diameter of said lumen is at least 3 millimeters.

17. The method of claim 1, wherein the torsion of said flexible tubular member is at least 150 gram(force)*cm per degree per cm length.

18. The method of claim 1, wherein said tubular member further comprises at least one pair of electrocardiogram electrodes on the outer surface.

19. The method of claim 18, wherein the positioning step further comprises using the electrocardiogram from said at least one pair of electrocardiogram electrodes to position said oximeter system adjacent to a predetermined blood-filled structure.

20. The method of claim 1, wherein said position is an airway position.

21. The method of claim 20, wherein said airway position is a tracheal position.

22. The method of claim 1, wherein said sensor housing further comprises an adjustable balloon configured to position said at least two light sources and said at least one detector adjacent to said blood-filled structure.

23. The method of claim 22, wherein said balloon is inflated by gas or by liquid.

24. The method of claim 22, further comprising measuring and displaying the internal wall pressure of said balloon.

25. The method of claim 22, wherein said balloon is inflated and deflated by manual or by automated operation.

26. The method of claim 1, wherein said system further comprises a stethoscope.

27. The method of claim 1, wherein said system further comprises at least one temperature sensor.

28. The method of claim 1, wherein said oximeter sensor includes a plurality of said light sources and photodetectors positioned to provide multiple simultaneous blood oxygen saturation measurements from multiple blood-filled structures.

29. The method of claim 1, wherein said display displays said distribution of said relative frequency of occurrence of oxygen saturations obtained within defined intervals

of oxygen saturation at a plurality of predetermined averaging intervals.

30. The method of claim 1, wherein the positioning step further comprises positioning said oximeter sensor with transesophageal echocardiography.