Multiwavelength surgical laser

• US 9,220,563 B1
• Filed: 12/29/2014
• Issued: 12/29/2015
• Est. Priority Date: 12/29/2014
• Status: Active Grant

• Current Assignee: Cyclone Biosciences LLC
• Original Assignee: InnovaQuartz, LLC
• Inventors: Griffin, Stephen E.
• Primary Examiner(s): Farah, Ahmed
• Application Number:
  US14/584,086
• Time in Patent Office: 365 Days
• Field of Search: 606 3- 18, 607/88, 607/89, 128/898
• US Class Current: 1/1
• CPC Class Codes: A61B 18/20 using laser
• CPC Class Codes: A61B 18/22 the beam being directed along or through a flexible conduit, e.g. an optical fibre; Couplings or hand-pieces therefor
• CPC Class Codes: A61B 2018/00547 Prostate
• CPC Class Codes: A61B 2018/00577 Ablation
• CPC Class Codes: A61B 2018/00589 Coagulation
• CPC Class Codes: A61B 2018/00601 Cutting
• CPC Class Codes: A61B 2018/00625 Vaporization
• CPC Class Codes: A61B 2018/1807 using light other than laser radiation
• CPC Class Codes: A61B 2018/2015 Miscellaneous features
• CPC Class Codes: A61B 2018/2035 Beam shaping or redirecting; Optical components therefor A61B2018/2255 takes precedence
• CPC Class Codes: A61B 2018/2065 Multiwave; Wavelength mixing, e.g. using four or more wavelengths
• CPC Class Codes: A61B 2018/207 mixing two wavelengths
• CPC Class Codes: A61B 2018/208 with multiple treatment beams not sharing a common path, e.g. non-axial or parallel
• CPC Class Codes: A61B 2018/2205 Characteristics of fibres
• CPC Class Codes: A61B 2018/2244 Features of optical fibre cables, e.g. claddings

Abstract

A multiwavelength laser-based intense light source is described having applications in incision, excision and ablation of soft tissues with minimal collateral tissue damage. The light source combines the output of a plurality of relatively low power laser sources, emitting radiation in the region of the electromagnetic spectrum bounded by approximately 350 nm to 450 nm, where the combined output may be coupled into a single fiber optic energy delivery device: a standard surgical probe. Spectral and spatial beam combining are used to produce an incoherent light source with relatively low average power at any given wavelength, but with high total power and superior M2 beam quality, targeting multiple chromophores in target tissue and tissue breakdown product chromophores for consistently high and target absorption without indiscriminant char interference throughout a surgical procedure.

Claims

1. A multiwavelength surgical tool comprising:

a plurality of laser sources each having an output wavelength in the range of about 340 nm to about 460 nm, the plurality of laser sources including a first-laser source and a second laser-source, the first-laser source and the second-laser source having output wavelengths which differ by at least 2 nm,

the first-laser source having an output wavelength which corresponds to an absorption maximum of a first-surgical chromophore in the range of about 340 nm to about 460 nm;

the second-laser source having an output wavelength which corresponds to an absorption maximum of a second-surgical chromophore in the range of about 340 nm to about 460 nm; and

the plurality of laser sources optically coupled to an interventional or diagnostic laser-delivery device;

wherein each output wavelength corresponds to an absorption maximum of a surgical chromophore, where the absorption maximum of the surgical chromophore is selected from an absorption peak, a bathochromic shift, and a hypochromic shift of an in vivo material;

the in vivo material is selected from an endogenous chromophore;

a thermal degradation product of the endogenous chromophore;

a light-induced variant of the endogenous chromophore;

a thermal degradation product of the light-induced variant of the endogenous chromophore;

a recombinant product of the endogenous chromophore; and

a mixture thereof.

2. The surgical tool of claim 1, wherein the plurality of laser sources consists of laser diodes each individually having outputs in the range of 340 nm to 460 nm.

3. The surgical tool of claim 2, wherein the first-laser source is a first laser diode that has an output at about 414 nm;

and wherein the second-laser source is a second laser diode that has an output at about 433 nm.

4. The surgical tool of claim 1, wherein the surgical tool is free of a laser source that has an output above about 500 nm.

5. The surgical tool of claim 1, wherein the first-laser source has an output wavelength that corresponds to an absorption maximum of deoxy-hemoglobin in the range of about 340 nm to about 460 nm, and

the second-laser source has an output wavelength that corresponds to an absorption maximum of oxy-hemoglobin in the range of about 340 nm to about 460 nm.

6. The surgical tool of claim 1 further comprising a beam combiner optically coupled to the laser sources, and to the surgical-laser-delivery device, the beam combiner adapted to accept light for the plurality of laser sources and combine the light into a single, polychromatic beam within the surgical-laser delivery device.

7. The surgical tool of claim 1, wherein the surgical-laser-delivery device includes a surgical optical fiber.

8. The surgical tool of claim 1, wherein the surgical tool comprises at least five laser sources each having output wavelengths in the range of about 340 nm to about 460 nm.

9. The surgical tool of claim 1, wherein the plurality of laser sources include output wavelengths corresponding to absorption maxima of a surgical chromophores selected from a bathochromatically shifted absorption peak of the endogenous chromophore, a hypsochromatically shifted absorption peak of the endogenous chromophore, an absorption peak of a thermal degradation product of the endogenous chromophore;

an absorption peak of a light-induced chromophore variant of the endogenous chromophore, an absorption peak of a thermal degradation product of the light-induced chromophore variant of the endogenous chromophore; and

an absorption peak of a recombinant product thereof.

10. A multiwavelength surgical tool comprising:

a plurality of laser sources each having an output wavelength in the range of about 340 nm to about 460 nm, the plurality of laser sources including

a first-laser source having an output wavelength which corresponds to an absorption maximum of deoxy-hemoglobin in the range of about 340 nm to about 460 nm;

a second-laser source having an output wavelength which corresponds to an absorption maximum of oxy-hemoglobin in the range of about 340 nm to about 460 nm;

a third-laser source which has an output wavelength that corresponds to an absorption shift maximum of deoxy-hemoglobin within the range of about 340 nm to about 460 nm; and

a fourth-laser source which has an output wavelength that corresponds to an absorption shift maximum of oxy-hemoglobin within the range of about 340 nm to about 460 nm; and

the plurality of laser sources optically coupled to an interventional or diagnostic laser-delivery device.