Bone graft materials and methods

• US 9,220,596 B2
• Filed: 10/07/2013
• Issued: 12/29/2015
• Est. Priority Date: 12/23/2010
• Status: Active Grant

• Current Assignee: Bioventus LLC
• Original Assignee: BioStructures, LLC (Bioventus LLC)
• Inventors: Cook, Russell L., Antone, Duraid S.
• Primary Examiner(s): Desai, Anand
• Assistant Examiner(s): LIU, SAMUEL W
• Application Number:
  US14/047,677
• Publication Number:
  US 20140031950A1
• Time in Patent Office: 813 Days
• Field of Search: None
• US Class Current: 1/1
• CPC Class Codes: A61F 2/28 Bones joints A61F2/30
• CPC Class Codes: A61F 2002/2835 Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
• CPC Class Codes: A61F 2310/00293 containing a phosphorus-containing compound, e.g. apatite
• CPC Class Codes: A61F 2310/00329 Glasses, e.g. bioglass
• CPC Class Codes: A61F 2310/00371 Collagen
• CPC Class Codes: A61L 2400/06 Flowable or injectable implant compositions
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/24 Collagen
• CPC Class Codes: A61L 27/446 with other specific inorganic fillers other than those covered by A61L27/443 or A61L27/46
• CPC Class Codes: A61L 27/46 with phosphorus-containing inorganic fillers
• CPC Class Codes: C08L 89/06 derived from leather or skin , e.g. gelatin

Abstract

Compositions, materials, methods and kits for bone grafting are described. In some embodiments, a bone graft composition includes about 15% to about 20% by weight collagen, about 55% to about 70% by weight bioactive glass, and about 15% to about 30% by weight a calcium phosphate. The bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition. In some embodiments, a bone graft composition includes a collagen matrix and a plurality of bioactive glass particulates dispersed throughout the collagen matrix. The collagen matrix is about 20% to about 60% by weight of the bone graft composition, and the bioactive glass is about 40% to about 80% of the bone graft composition. In some embodiments, a majority of the bioactive glass particulates are about 53 μm to about 425 μm in size.

Claims

1. A bone graft composition comprising:

about 15% to about 20% by weight collagen;

about 55% to about 70% by weight bioactive glass, the bioactive glass having a size within a range of about 53 μ

m to about 425 μ

m in size, at least 85% of the bioactive glass having a size within a range of 212 μ

m to 425 μ

m in size; and

about 15% to about 30% by weight calcium phosphate.

2. The bone graft composition of claim 1, wherein the bioactive glass and the calcium phosphate together are about 80% to about 85% by weight of the bone graft composition.

3. The bone graft composition of claim 1, wherein the collagen is type I collagen.

4. The bone graft composition of claim 1, wherein the bioactive glass includes particles having a smooth surface.

5. The bone graft composition of claim 1, wherein the calcium phosphate comprises about 40% to about 80% tricalcium phosphate and about 20% to about 60% hydroxyapatite.

6. The bone graft composition of claim 5, further comprising about 15% by weight type I collagen, about 55% to about 65% by weight bioactive glass, and about 20% to about 30% by weight calcium phosphate.

7. The bone graft composition of claim 6, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:

55%;

30%, respectively.

8. The bone graft composition of claim 6, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:

60%;

25%, respectively.

9. The bone graft composition of claim 6, wherein a weight ratio of the collagen to the bioactive glass to the calcium phosphate is about 15%:

65%;

20%, respectively.

10. The bone graft composition of claim 1, wherein the bioactive glass is 45S5 glass.

11. A bone graft composition consisting of:

a collagen and a bioactive glass dispersed throughout the collagen, the bioactive glass having a size within a range of about 53 μ

m to about 425 μ

m, at least 85% of the bioactive glass having a size within a range of 212 μ

m to 425 μ

m;

the collagen and the bioactive glass collectively comprising 100% by weight of the bone graft composition, the collagen being about 20% to about 60% by weight of the bone graft composition and the bioactive glass is about 40% to about 80% by weight of the bone graft composition.

12. The bone graft composition of claim 11, wherein the collagen is in the form of a porous matrix.

13. The bone graft composition of claim 11, wherein the bioactive glass has a smooth surface.

14. The bone graft composition of claim 11, wherein the bioactive glass is about 80% by weight of the bone graft composition.

15. The bone graft composition of claim 11, wherein the bioactive glass is about 60% by weight of the bone graft composition.

16. The bone graft composition of claim 11, wherein the bioactive glass is 45S5 glass.

17. The bone graft composition of claim 11, wherein the collagen includes type I collagen.