Resveratrol ferulate compounds, compositions containing the compounds, and methods of using the same

• US 9,220,669 B2
• Filed: 05/07/2010
• Issued: 12/29/2015
• Est. Priority Date: 09/08/2007
• Status: Active Grant

• Current Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Original Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Inventors: Bratescu, Daniela, Mohammadi, Faterneh, Zecchino, Julius R., Daneshyar, Fred
• Primary Examiner(s): SHIAO, REI TSANG
• Application Number:
  US12/775,676
• Publication Number:
  US 20100215755A1
• Time in Patent Office: 2,062 Days
• Field of Search: 424/62, 514/532, 514/533
• US Class Current: 1/1
• CPC Class Codes: A61K 2800/31 Anhydrous
• CPC Class Codes: A61K 2800/522 Antioxidants; Radical scavengers
• CPC Class Codes: A61K 8/375 the alcohol moiety containing more than one hydroxy group
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61P 17/18 Antioxidants, e.g. antiradicals preparations for protection against sunlight A61Q17/00
• CPC Class Codes: A61P 39/06 Free radical scavengers or antioxidants
• CPC Class Codes: A61Q 1/02 Preparations containing skin colorants, e.g. pigments preparations in powder form A61Q1/12
• CPC Class Codes: A61Q 19/02 for chemically bleaching or whitening the skin
• CPC Class Codes: A61Q 19/08 Anti-ageing preparations

Abstract

The present invention relates to methods of using topical or cosmetic compositions containing resveratrol ferulates for skin lightening and anti-aging applications and method of synthesizing resveratrol ferulates.

Claims

1. A method for lightening skin and/or reducing reactive oxygen species in skin in need of thereof comprising applying to said skin a cosmetic composition comprising an ester of resveratrol consisting of a mixture of 3-ferulate-5,4′

-dihydroxystilbene;

4′

-ferulate-3,5-dihydroxystilbene;

3,5-diferulate-4′

-hydroxystilbene;

3,4′

-diferulate-5-hydroxystilbene;

3,5,4′

-triferulate-hydroxystilbene.

2. The method of claim 1 for lightening skin wherein the cosmetic composition is applied to selected areas of skin with hyperpigmentation to reduce hyperpigmentation in such selected areas.

3. The method of claim 1, wherein the cosmetic composition is applied to facial skin to achieve skin lightening and/or reducing reaction oxygen species thereon.

4. The method of claim 1, wherein the mixture is present in the cosmetic composition in an amount ranging from about 0.001% to about 20% by total weight of the composition.

5. The method of claim 4, wherein the mixture is encapsulated by one or more vesicles, microspheres, nanospheres, capsules, or mixtures thereof.

6. The method of claim 1, wherein the topically or cosmetically acceptable carrier is an emulsion comprising an aqueous phase and an oil phase.

7. The method of claim 6, wherein the mixture is dispersed or solubilized in the aqueous phase of the emulsion.

8. The method of claim 6, wherein the mixture is dispersed or solubilized in the oil phase of the emulsion.

9. The method of claim 1, wherein the cosmetic composition is anhydrous.