Substituted diketopiperazine analogs for use as drug delivery agents
First Claim
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1. A method for stabilizing an active agent comprising:
- spray drying a solution of an active agent molecule and a pharmaceutically acceptable salt of a substituted diketopiperazine to form a dry powder;
wherein the pharmaceutically acceptable salt of a substituted diketopiperazine has the general structure of Formula A;
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Abstract
Disclosed are drug delivery systems for the delivery of small molecule and macromolecular drugs. More particularly, disclosed are substituted analogs of 3,6-di(alkyl-4 aminobutyl)-2,5-diketopiperazine (which may also be referred to DKP), their use in the formulation of both small molecule and macromolecular drugs including therapeutic, prophylactic and diagnostic agents, stabilizing agents and systems for their delivery.
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Citations
21 Claims
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1. A method for stabilizing an active agent comprising:
- spray drying a solution of an active agent molecule and a pharmaceutically acceptable salt of a substituted diketopiperazine to form a dry powder;
wherein the pharmaceutically acceptable salt of a substituted diketopiperazine has the general structure of Formula A;
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
- spray drying a solution of an active agent molecule and a pharmaceutically acceptable salt of a substituted diketopiperazine to form a dry powder;
Specification