In vivo production of proteins
First Claim
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1. A method of producing a polypeptide of interest in vivo comprising contacting a mammalian cell, tissue or organism with at least one isolated mRNA encoding the polypeptide of interest, said at least one isolated mRNA comprisinga first region of linked nucleosides, said first region of linked nucleosides encoding SEQ ID NO:
- 320;
and wherein said first region of linked nucleosides comprise a coding region having at least 80% identity to SEQ ID NO;
321.
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Abstract
The invention relates to compositions and methods for the preparation, manufacture and therapeutic use of polynucleotides, primary transcripts and mmRNA molecules.
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13 Claims
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1. A method of producing a polypeptide of interest in vivo comprising contacting a mammalian cell, tissue or organism with at least one isolated mRNA encoding the polypeptide of interest, said at least one isolated mRNA comprising
a first region of linked nucleosides, said first region of linked nucleosides encoding SEQ ID NO: - 320;
and wherein said first region of linked nucleosides comprise a coding region having at least 80% identity to SEQ ID NO;
321.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
- 320;
Specification