Device and method for detecting and monitoring ingredients or properties of a measurement medium, in particular of physiological blood values

• US 9,222,832 B2
• Filed: 06/21/2011
• Issued: 12/29/2015
• Est. Priority Date: 06/22/2010
• Status: Active Grant

• Current Assignee: Senspec GmbH
• Original Assignee: Senspec GmbH
• Inventors: Kulcke, Axel
• Primary Examiner(s): Winakur, Eric
• Application Number:
  US13/699,488
• Publication Number:
  US 20130066172A1
• Time in Patent Office: 1,652 Days
• Field of Search: 600/310, 600/322, 600/323
• US Class Current: 1/1
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/6801 specially adapted to be attached to or worn on the body surface
• CPC Class Codes: A61B 5/7239 using differentiation including higher order derivatives
• CPC Class Codes: G01J 3/021 using plane or convex mirrors, parallel phase plates, or particular reflectors
• CPC Class Codes: G01J 3/0256 Compact construction
• CPC Class Codes: G01J 3/0264 Electrical interface; User interface
• CPC Class Codes: G01J 3/1838 Holographic gratings
• CPC Class Codes: G01J 3/2803 using photoelectric array detector
• CPC Class Codes: G01J 3/42 Absorption spectrometry; Double beam spectrometry; Flicker spectrometry; Reflection spectrometry beam switching arrangements G01J3/08
• CPC Class Codes: G01N 2021/3144 for oxymetry
• CPC Class Codes: G01N 21/31 Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry G01N21/72 takes precedence
• CPC Class Codes: G01N 2201/062 LED's

Abstract

The invention relates to a device for detecting and monitoring ingredients or properties of a measurement medium, for example physiological blood values, wherein said device contains a light source (20) for generating broad-spectrum measurement light (2) and for acting on a measurement area (3), and means (9) for fanning out the analysis light (4) reflected by the measurement area (3). The device also has a sensor array (11) for picking up the fanned light. The sensor array (11), the light source (20) and the means for dispersing the analysis light (4) are arranged as a compact unit in a housing.

Claims

1. A device for identifying and monitoring contents or properties of a measurement medium comprising

at least one broadband light source for generating broadband analysis light, [directly acting on a measurement region,]

a dispersive optical element for spreading the analysis light according to the wavelength thereof, which analysis light has been returned by at least one measurement point or has passed through the measurement point,

a two-dimensional sensor array for recording the spread analysis light, which two-dimensional sensor array is arranged such that light with different wavelengths impinges on different points of the sensor array, and such that the spread analysis light impinges on a plurality of adjacent rows of the two-dimensional sensor array such that the spectrum can simultaneously be captured by a plurality of rows of the two-dimensional sensor array,

the device having a housing and being designed as a compact assembly which contains at least the light source, the dispersive optical element and the sensor array, the housing configured to position the light source for directly acting on the measurement region when the housing is aligned with respect to the measurement region and

a computer arrangement which adds the sprectra generated by the adjacent rows to improve the signal to noise ratio.

2. The device as claimed in claim 1, wherein the housing is designed to be affixed to a point on the body of a human patient or to a line for the measurement medium.

3. The device as claimed in claim 2, wherein the housing is designed to be affixed to the finger or an earlobe.

4. The device as claimed in claim 1, wherein the dispersive optical element is a diffraction grating.

5. The device as claimed in claim 4, said diffraction grating being a holographic grating.

6. The device as claimed in claim 1, wherein the device has a slit aperture, which is arranged between an inlet region for the analysis light and the dispersive optical element.

7. The device as claimed in claim 6, wherein the slit aperture is arranged with respect to the dispersive optical element such that an elongate image is spread open in a direction different from the main axis of the elongate image.

8. The device as claimed in claim 1, wherein the device has an analog/digital converter.

9. The device as claimed in claim 1, wherein the device has an amplifier.

10. The device as claimed in claim 9, wherein the amplifier can be parameterized.

11. The device as claimed in claim 1, wherein the device has a connector for an electrical communication connection.

12. The device as claimed in claim 1, wherein the device is designed to measure transmission and reflection.

13. The device as claimed in claim 12, wherein said computer arrangement is designed such that it is alternately possible to carry out a transmission measurement and a reflection measurement, with the device having a first broadband light source for carrying out a reflection measurement by illuminating a first measurement region and a second broadband light source for illuminating a second measurement region for carrying out a transmission measurement.

14. The device as claimed in claim 12, wherein the device is provided with means for separating the analysis light out of a reflection region and a transmission region.

15. The device as claimed in claim 1, wherein the device is designed for scanning with a frequency>

50 Hz, with it being possible to establish a tissue component and a pulsatile component of the measured physiological blood values.

16. The device as claimed in claim 1, wherein said computer arrangement being designed such that the measurements can be carried out in a time-resolved fashion.

17. The device as claimed in claim 16, said computer arrangement being an external computer arrangement.

18. The device as claimed in claim 1, said computer arrangement being designed such that it is possible to establish a second derivative of the captured spectra and that physiological blood values in particular can he established on the basis of this second derivative.

19. The device as claimed in claim 18, said computer arrangement being an external computer arrangement.

20. A device as claimed in claim 1, wherein said computer arrangement is arranged external and wherein the device and the computer arrangement are or can be interconnected by means of a communication cable.

21. The device as claimed in claim 1, for identifying and monitoring wherein said contents or properties are physiological blood values.

22. The device as claimed in claim 1, wherein said broadband light comprises at least one of 500 nm to 850 nm and 800 nm to 1200 nm.

23. The device as claimed in claim 1, wherein said light source is a LED.

24. The device as claimed in claim 1, wherein said two-dimensional sensor is a two-dimensional CMOS array.

25. A method for identifying and monitoring contents or properties of a measurement medium, comprising steps of:

applying broadband light from a broadband light source directly onto at least the measurement region,

capturing analysis light returned in reflection and/or transmission mode,

carrying out wave-dependent spreading of the captured analysis light and imaging the individual, wavelength-dependent components of the captured analysis light on a two-dimensional sensor array, for generating a spectrum,

wherein the spread analysis light is imaged on a plurality of adjacent rows of the two-dimensional sensor array to capture the spectrum simultaneously by a plurality of rows of the two-dimensional sensor array,

evaluating the spectrum generated thus for establishing the contents or properties of the measurement medium,

wherein the spectrum generated by the individual rows are added for improvement of signal to noise ratio,

wherein a housing is applied, in advance, to a measurement region, which housing contains the light source and the sensor array and positions the light source for directly illuminating the measurement region.

26. The method as claimed in claim 25, wherein the analysis is light is spread at a diffraction grating.

27. The method as claimed in claim 25, wherein the analysis light is captured in a reflection mode and in a transmission mode.

28. The method as claimed in claim 25, wherein the analysis light is evaluated in a time-resolved fashion.

29. The method as claimed in claim 25, wherein the second derivative of the captured spectra is established for establishing the physiological blood values.

30. The method as claimed in claim 25, wherein scanning is undertaken at a frequency of greater than 50 Hz and wherein a tissue component and a pulsatile component of the measured physiological blood values are established.

31. The method according to claim 25 wherein said content or properties are physiological blood values of a living being.

32. The method according to claim 25 wherein said two-dimensional sensor array is a two-dimensional CCD-camera.

33. The method according to claim 25 wherein said housing is applied in advance to a measurement region of a living being.