Magnetic resonance relaxation along a fictitious field

• US 9,222,999 B2
• Filed: 04/09/2012
• Issued: 12/29/2015
• Est. Priority Date: 04/08/2011
• Status: Active Grant

• Current Assignee: Regents of The University of Minnesota (University of Minnesota)
• Original Assignee: Regents of The University of Minnesota (University of Minnesota)
• Inventors: Michaeli, Shalom, Mangia, Silvia, Sorce, Dennis J., Garwood, Michael G., Liimatainen, Timo
• Primary Examiner(s): Vargas, Dixomara
• Application Number:
  US13/442,597
• Publication Number:
  US 20120286780A1
• Time in Patent Office: 1,359 Days
• Field of Search: 324300-322, 600407-435, 382128-131
• US Class Current: 1/1
• CPC Class Codes: G01R 33/446 Multifrequency selective RF pulses, e.g. multinuclear acquisition mode spatially selective RF pulses G01R33/4833
• CPC Class Codes: G01R 33/50 based on the determination of relaxation times , e.g. T1 measurement by IR sequences; T2 measurement by multiple-echo sequences

Abstract

A system includes a driving module, a processor, and a readout module. The driving module is configured to apply a perturbation to a sample. The processor is configured to define a plurality of different rotating frames relative to the perturbation, wherein each frame has a corresponding fictitious field. The readout module is coupled to the processor and is configured to generate an output based on relaxation of the sample as a function of the perturbation.

Claims

1. A magnetic resonance (MR) system comprising:

a driving module configured to apply a perturbation to a sample;

a processor configured to generate RF modulated pulses, the RF modulated pulses configured to define a plurality of at least three different rotating frames of reference relative to the perturbation, the plurality of at least three different rotating frames of reference including at least two frames in which each frame of the at least two frames includes a fictitious field and wherein at least one fictitious field is time variant, the fictitious fields are produced by an interaction of the plurality of the at least three different rotating frames of reference, and each different rotating frame is associated with an effective field, wherein the fictitious fields and the effective fields are associated with the generated modulated pulses and the modulated pulses are produced by a recursive expansion; and

a readout module coupled to the processor and configured to generate an output based on a relaxation of spins of the sample as a function of the perturbation in order to display or store a magnetic resonance output with the readout module.

2. The system of claim 1 wherein the processor is configured to generate a frequency swept pulse, wherein the frequency swept pulse corresponds to a modulated pulse of the generated modulated pulses.

3. The system of claim 1 wherein the driving module is configured to deliver a frequency swept pulse, wherein the frequency swept pulse corresponds to a modulated pulse of the generated modulated pulses.

4. The system of claim 1 wherein the driving module is configured to apply a pulse train, wherein the pulse train corresponds to the generated modulated pulses.

5. The system of claim 1 wherein the processor is configured to instantaneously flip a magnetization of the fictitious field.

6. The system of claim 1 further including at least one of a display or a printer that is coupled to the readout module, wherein the display or the printer is configured to render a visible image corresponding to the output from the readout module.

7. The system of claim 1 wherein at least one rotating frame of reference of the spin system includes modulation of amplitude or frequency based on a tangent function.

8. A magnetic resonance method comprising:

applying a perturbation to a system;

generating RF modulated pulses, the RF modulated pulses configured to define a plurality of at least three different rotating frames relative to the perturbation, the plurality of at least three different rotating frames including at least two frames in which each frame of the at least two frames includes fictitious field and wherein at least one fictitious field is time dependent, the fictitious fields produced by interaction of the plurality of at least three different rotating frames, and wherein each different rotating frame is associated with an effective field and wherein the fictitious fields and the effective fields are associated with the modulated pulses and the modulated pulses are produced by a recursive expansion; and

applying a readout module to the system after applying the perturbation in order to display or store a magnetic resonance output with the readout module.

9. The method of claim 8 wherein applying the perturbation to the system includes applying a magnetic perturbation to a spin system using a magnetic resonance system.

10. The method of claim 8 wherein at least one fictitious field remains constant in the at least one rotating frame of the at least three different rotating frames.

11. The method of claim 8 further including decreasing a relaxation of the spin system in a selected rotating frame of the plurality of at least three different rotating frames.

12. The method of claim 8 further including generating a rotating frame rotary echo in the spin system using a magnetic resonance system.

13. The method of claim 8 further including locking a magnetization of the system to a fictitious field of a selected rotating frame of the at least three different rotating frames.

14. The method of claim 8 further wherein at least one fictitious field is non-stationary.

15. The method of claim 8 wherein applying the perturbation to the system includes applying a frequency swept pulse.

16. The method of claim 8 wherein at least one fictitious field of the system remains constant in amplitude.

17. The method of claim 8 wherein at least two of the fictitious fields of the system are time dependent.

18. The method of claim 8 wherein at least one fictitious field of the system remains constant in a direction.

19. A non-transitory processor-implemented method which, when executed, causes a magnetic resonance system to generate a magnetic resonance image, the method comprising:

selecting a rank for a fictitious frame of reference that images a region of interest in a spin system, wherein the selected rank corresponds to at least three different fictitious frames of reference;

generating a sequence of modulated pulses that excites the spin system with the sequence of modulated pulses having a sweeping frequency and both a modulated amplitude and phase in which the effective field varies with time in the fictitious frame, wherein the effective field is associated with the sequence of modulated pulses and wherein the sequence of modulated pulses are produced by a recursive expansion;

acquiring magnetic resonance data corresponding to the spin system, the data corresponding to relaxation of spins in the region of interest based on excitation from the sequence of modulated pulses; and

generating an MR image with a processor based on the acquired data.

20. The method of claim 19 wherein the sequence of modulated pulses includes at least one pulse that is sub-adiabatic.

21. The method of claim 19 wherein the rank is greater than 2.

22. A magnetic resonance (MR) system comprising:

a driving module configured to apply a perturbation to a sample;

a processor configured to generate modulated pulses to define at least n different rotating frames of reference where n is an integer of at least three, the rotating frames of reference including at least n−

1 frames in which each of the n−

1 frames includes a fictitious field and wherein at least one fictitious field is time variant, the fictitious fields produced by interaction of the plurality of at least n different rotating frames of reference, and wherein each different rotating frame of reference is associated with an effective field and wherein the fictitious fields and the effective fields are associated with the modulated pulses and the modulated pulses are produced by a recursive expansion; and

a readout module coupled to the processor and configured to generate an output based on relaxation of spins of the sample as a function of the perturbation that is displayed or stored by the MR system.