Photoacoustic apparatus

• US 9,226,662 B2
• Filed: 10/20/2010
• Issued: 01/05/2016
• Est. Priority Date: 10/29/2009
• Status: Active Grant

• Current Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Original Assignee: Canon Kabushiki Kaisha (Canon Inc.)
• Inventors: Someda, Yasuhiro
• Primary Examiner(s): Assouad, Patrick
• Assistant Examiner(s): Zhang, Haidong
• Application Number:
  US12/908,232
• Publication Number:
  US 20110106478A1
• Time in Patent Office: 1,903 Days
• Field of Search: 702/104, 600/431, 600/437, 600/438
• US Class Current: 1/1
• CPC Class Codes: A61B 2576/00 Medical imaging apparatus involving image processing or analysis A61B1/00009, A61B6/52 and A61B8/52 take precedence; image processing per se G06T; details of algorithms for analysing medical images G06T7/0012
• CPC Class Codes: A61B 5/0059 using light, e.g. diagnosis by transillumination, diascopy, fluorescence A61B5/0093, A61B5/1455, A61B5/02416 and A61B5/0261 take precedence
• CPC Class Codes: A61B 5/0062 Arrangements for scanning
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: A61B 8/08 Detecting organic movements or changes, e.g. tumours, cysts, swellings A61B8/02 - A61B8/06 take precedence
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids

Abstract

In a photoacoustic apparatus, a light source irradiates an inspection target with pulsed light; a detector detects acoustic waves generated in the inspection target due to interaction of the pulsed light with the inspection target, and outputs detection signals corresponding to the detected acoustic waves; a light-quantity measurement unit measures the quantity of the light output from the light source; and a signal processor obtains information on an inside of the inspection target by using the detection signals output from the detector. The signal processor also corrects intensities of the detection signals so as to suppress variations in intensities of the detection signals caused by a temporal change in the quantity of the light.

Claims

1. A photoacoustic apparatus comprising:

a light source which irradiates an inspection target with pulsed light;

a detector having a plurality of transducer elements, each of which detects an acoustic wave generated due to irradiating the inspection target with the pulsed light and outputs a detection signal;

a light-quantity measurement unit which measures a quantity of the pulsed light output from the light source; and

a signal processor which obtains information on an inside of the inspection target by processing a plurality of detection signals output from the plurality of transducer elements,

wherein the signal processor includes a signal correction unit which corrects the plurality of detection signals based on the quantity of the pulsed light measured by the light-quantity measurement unit so that variations in intensities of the plurality of detection signals, caused by a temporal change in the quantity of the pulsed light output from the light source, are suppressed.

2. The photoacoustic apparatus according to claim 1, further comprising:

a correction-amount determination unit which determines correction amounts for correcting the plurality of detection signals based on the quantity of the pulsed light measured by the light-quantity measurement unit,

wherein the signal correction unit corrects the plurality of detection signals using the correction amounts determined by the correction-amount determination unit.

3. The photoacoustic apparatus according to claim 2, further comprising:

a memory which stores the quantity of the pulsed light measured by the light-quantity measurement unit,

wherein the correction-amount determination unit reads data regarding the temporal change in the quantity of pulsed light stored in the memory.

4. The photoacoustic apparatus according to claim 1,

wherein the signal processor includes an A/D converter which converts the plurality of detection signals which are analog signals obtained by the plurality of transducer elements into a plurality of digital signals, and

the signal correction unit performs the correction on the plurality of digital signals.

5. The photoacoustic apparatus according to claim 4,

wherein the signal processor further includes an image reconstruction processor which obtains image reconstruction data by performing image reconstruction on the plurality of detection signals, and

the signal correction unit performs the correction on the plurality of digital signals which has been subjected to the image reconstruction.

6. The photoacoustic apparatus according to claim 2,

wherein the correction-amount determination unit determines the correction amounts for the plurality of detection signals in accordance with an attenuation of the pulsed light inside the inspection target.

7. The photoacoustic apparatus according to claim 2,

wherein the correction-amount determination unit determines the correction amounts for the plurality of detection signals in accordance with an in-plane intensity distribution of the pulsed light from the light source.

8. The photoacoustic apparatus according to claim 6, wherein

the light source includes a plurality of light sources;

wherein the light-quantity measurement unit measures quantities of pulsed lights output from the light sources, and

wherein the correction-amount determination unit determines the correction amounts for correcting the plurality of detection signals based on the quantities of the pulsed lights measured by the light-quantity measurement units.

9. The photoacoustic apparatus according to claim 1, further comprising:

plates which press and fix the inspection target from opposite sides of the inspection target; and

a movement mechanism which moves a portion in which the pulsed light is incident on, the detector, and the light-quantity measurement unit along the plates for scanning.

10. The photoacoustic apparatus according to claim 5,

wherein the image reconstruction processor obtains image reconstruction data in three-dimensional space by performing image reconstruction on the plurality of detection signals corrected by the signal correction unit, obtains the intensity distribution of the pulsed light in three-dimensional space inside the inspection target based on light attenuation inside the inspection target, and obtains the information on the inside of the inspection target in three-dimensional space using the image reconstruction data in three-dimensional space and the intensity distribution of the pulsed light in three-dimensional space inside the inspection target.

11. A photoacoustic apparatus comprising:

a light source which irradiates an inspection target with pulsed light;

a detector having a plurality of transducer elements, each of which detects an acoustic wave generated due to irradiating the inspection target with the pulsed light and outputs an analog signal;

a light-quantity measurement unit which measures a quantity of the pulsed light output from the light source; and

a signal processor which includes an A/D converter which converts a plurality of analog signals output from the plurality of transducer elements into a plurality of digital signals and an image reconstruction processor which performs image reconstruction,

wherein the signal processor includes a signal correction unit which corrects the plurality of digital signals based on the quantity of the pulsed light measured by the light-quantity measurement unit so that variations in the intensities of the plurality of digital signals, caused by a temporal change in the quantity of the pulsed light output from the light source, are suppressed, and

wherein the image reconstruction processor obtains image reconstruction data by performing image reconstruction using output signals from the signal correction unit.

12. The photoacoustic apparatus according to claim 11,

wherein the signal correction unit corrects the plurality of digital signals so that an influence of light attenuation caused inside the inspection target is suppressed.

13. The photoacoustic apparatus according to claim 11,

wherein the image reconstruction processor obtains an intensity distribution of the pulsed light inside the inspection target based on light attenuation inside the inspection target and obtains information on an inside of the inspection target using the image reconstruction data and the intensity distribution of the pulsed light inside the inspection target.

14. The photoacoustic apparatus according to claim 11,

wherein the image reconstruction processor obtains the intensity distribution of the pulsed light inside the inspection target based on light attenuation inside the inspection target and an in-plane intensity distribution of the pulsed light from the light source, and obtains information on an inside of the inspection target using the image reconstruction data and the intensity distribution of the pulsed light inside the inspection target.

15. The photoacoustic apparatus according to claim 11,

wherein the image reconstruction processor obtains image reconstruction data in three-dimensional space by performing image reconstruction on the plurality of detection signals corrected by the signal correction unit, obtains the intensity distribution of the pulsed light in three-dimensional space inside the inspection target based on light attenuation inside the inspection target, and obtains information on an inside of the inspection target in three-dimensional space using the image reconstruction data in three-dimensional space and the intensity distribution of the pulsed light in three-dimensional space inside the inspection target.

16. A photoacoustic apparatus comprising:

a light source which irradiates an inspection target with pulsed light;

a detector having a plurality of transducer elements, each of which detects an acoustic wave generated due to irradiating the inspection target with the pulsed light and outputs a detection signal; and

a signal processor which obtains information on an inside of the inspection target by processing a plurality of detection signals output from the plurality of transducer elements,

wherein the signal processor includes a signal correction unit which corrects the plurality of detection signals so that variations in intensities of the plurality of detection signals, caused by a temporal change in the quantity of light output from the light source, are suppressed, and

wherein the signal processor includes an image reconstruction processor which obtains image reconstruction data in three-dimensional space by performing image reconstruction on the plurality of detection signals corrected by the signal correction unit, obtains an intensity distribution of the pulsed light in three-dimensional space inside the inspection target based on light attenuation inside the inspection target, and obtains the information on the inside of the inspection target in three-dimensional space using the image reconstruction data in three-dimensional space and the intensity distribution of the pulsed light in three-dimensional space inside the inspection target.

17. The photoacoustic apparatus according to claim 16,

wherein the image reconstruction processor obtains the intensity distribution of the pulsed light in three-dimensional space inside the inspection target based on the light attenuation inside the inspection target and an in-plane intensity distribution of the pulsed light from the light source.

18. A method of performing photoacoustic imagining, comprising:

irradiating an inspection target with pulsed light emitted from a light source;

obtaining, using a detector having a plurality of transducer elements, a plurality of detection signals by detecting with each transducer element an acoustic wave generated due to irradiating the inspection target with the pulsed light at a plurality of positions; and

processing the plurality of detection signals with a signal processor, the processing comprises;

obtaining a plurality of corrected detection signals by correcting the plurality of detection signals so that variations in intensities of the plurality of detection signals, caused by a temporal change in a quantity of the pulsed light, are suppressed;

obtaining information on an inside of the inspection target by processing the plurality of corrected detection signals,

obtaining image reconstruction data in three-dimensional space by performing image reconstruction on the plurality of corrected detection signals;

obtaining an intensity distribution of the pulsed light in three-dimensional space inside the inspection target based on light attenuation inside the inspection target; and

obtaining the information on the inside of the inspection target in three-dimensional space using the image reconstruction data in three-dimensional space and the intensity distribution of the pulsed light in three-dimensional space inside the inspection target.

19. The method of performing photoacoustic imaging according to claim 18,

wherein the intensity distribution of the pulsed light in three-dimensional space inside the inspection target is obtained based on the light attenuation inside the inspection target and an in-plane intensity distribution of the pulsed light from the light source.