Devices, systems, and methods for the fabrication of tissue
DCFirst Claim
1. A three-dimensional bioprinter comprising:
- a. one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, wherein a cartridge comprises at least one deposition orifice and contents comprising a bio-ink, wherein the bio-ink comprises a solid or semi-solid composition of living cells;
b. a means for calibrating a position in space of the at least one cartridge or the at least one deposition orifice utilizing an optical detector;
c. a means for extruding the contents of the at least one cartridge by application of pressure;
d. a receiving surface for receiving the extruded contents of the at least one cartridge; and
e. a programmable computer processor communicatively connected to the means for calibrating and the means for extruding, the programmable computer processor for positioning the one or more printer heads in three dimensions and regulating the extrusion of the contents of the at least one cartridge.
1 Assignment
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Accused Products
Abstract
Described herein are bioprinters comprising: one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, and wherein said cartridge comprises contents selected from one or more of: bio-ink and support material; a means for calibrating the position of at least one cartridge; and a means for dispensing the contents of at least one cartridge. Further described herein are methods for fabricating a tissue construct, comprising: a computer module receiving input of a visual representation of a desired tissue construct; a computer module generating a series of commands, wherein the commands are based on the visual representation and are readable by a bioprinter; a computer module providing the series of commands to a bioprinter; and the bioprinter depositing bio-ink and support material according to the commands to form a construct with a defined geometry.
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Citations
15 Claims
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1. A three-dimensional bioprinter comprising:
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a. one or more printer heads, wherein a printer head comprises a means for receiving and holding at least one cartridge, wherein a cartridge comprises at least one deposition orifice and contents comprising a bio-ink, wherein the bio-ink comprises a solid or semi-solid composition of living cells; b. a means for calibrating a position in space of the at least one cartridge or the at least one deposition orifice utilizing an optical detector; c. a means for extruding the contents of the at least one cartridge by application of pressure; d. a receiving surface for receiving the extruded contents of the at least one cartridge; and e. a programmable computer processor communicatively connected to the means for calibrating and the means for extruding, the programmable computer processor for positioning the one or more printer heads in three dimensions and regulating the extrusion of the contents of the at least one cartridge. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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Specification