Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds
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Abstract
1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.
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21 Claims
- 1. A compound of the formula:
- 8. A compound of the formula:
- 11. A compound of the formula:
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14. A dibenzocyclooctyne having a biotin fragment attached thereto.
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15. A compound of the formula:
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16. A dibenzocyclooctyne having a covalently bound organic dye attached thereto.
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17. A compound of the formula:
- 18. A dibenzocyclooctyne having a nanoparticle attached thereto.
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20. A compound of the formula:
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21. A compound of the formula:
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