Thin films for controlled cell growth
First Claim
1. A method for controlling the attachment and growth of cells on a surface of an article, the method comprising contacting the article with living tissue, living organisms, or with water in an aqueous system comprising living organisms wherein the article comprises a substratum having a surface and a film on the surface, the film comprising a network of a net positively charged composition and a net negatively charged composition, wherein the net positively charged composition comprises a net positively charged polyelectrolyte or the net negatively charged composition comprises a net negatively charged polyelectrolyte, a net positively charged polyelectrolyte or the net negatively charged polyelectrolyte contains (i) a polymer repeat unit having at least two fluorine atoms, or (ii) a polymer repeat unit having a zwitterion group, and the film comprises a surface region at which a net positively charged polyelectrolyte having zwitterion repeat units, a net negatively charged polyelectrolyte having zwitterion repeat units, a net positively charged polyelectrolyte comprising a repeat unit having at least two fluorine atoms, or a net negatively charged polyelectrolyte comprising a repeat unit having at least two fluorine atoms is exposed.
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Abstract
A method for controlling the attachment and growth of cells on a surface of an article, the method comprising contacting the article with living tissue, living organisms, or with water in an aqueous system comprising living organisms wherein the article comprises a substratum having a surface and a film on the surface, the film comprising a network of a net positively charged composition and a net negatively charged composition, wherein the net positively charged composition comprises a net positively charged polyelectrolyte or the net negatively charged composition comprises a net negatively charged polyelectrolyte, and the net positively charged polyelectrolyte or the net negatively charged polyelectrolyte contain (i) a polymer repeat unit having at least two fluorine atoms, or (ii) a polymer repeat unit having a zwitterion group.
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Citations
17 Claims
- 1. A method for controlling the attachment and growth of cells on a surface of an article, the method comprising contacting the article with living tissue, living organisms, or with water in an aqueous system comprising living organisms wherein the article comprises a substratum having a surface and a film on the surface, the film comprising a network of a net positively charged composition and a net negatively charged composition, wherein the net positively charged composition comprises a net positively charged polyelectrolyte or the net negatively charged composition comprises a net negatively charged polyelectrolyte, a net positively charged polyelectrolyte or the net negatively charged polyelectrolyte contains (i) a polymer repeat unit having at least two fluorine atoms, or (ii) a polymer repeat unit having a zwitterion group, and the film comprises a surface region at which a net positively charged polyelectrolyte having zwitterion repeat units, a net negatively charged polyelectrolyte having zwitterion repeat units, a net positively charged polyelectrolyte comprising a repeat unit having at least two fluorine atoms, or a net negatively charged polyelectrolyte comprising a repeat unit having at least two fluorine atoms is exposed.
Specification